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International Journal of Colorectal Disease

Published in:

01-03-2012 | Original Article

Clinicopathologic features and prognostic analysis of MSI-high colon cancer

Authors: Chun-Chi Lin, Yi-Ling Lai, Tzu-Chen Lin, Wei-Shone Chen, Jeng-Kai Jiang, Shung-Haur Yang, Huann-Sheng Wang, Yuan-Tzu Lan, Wen-Yih Liang, Hui-Mei Hsu, Jen-Kou Lin, Shih-Ching Chang

Published in: International Journal of Colorectal Disease | Issue 3/2012

Abstract

Purpose

The objectives of the study were to estimate the incidence and clarify the clinicopathologic feature of sporadic microsatellite instability (MSI)-high (MSI-H) colon cancer. Furthermore, the role of MSI in colon cancer prognosis was also investigated.

Methods

Microsatellite status was identified by genotyping. The clinicopathologic differences between two groups (MSI-H vs. MSI-L/S) and the prognostic value of MSI were analyzed.

Results

From 1993 to 2006, 709 sporadic colon cancer patients were enrolled. MSI-H colon cancers showed significant association with poorly differentiated (28.3% vs. 7.2%, p = 0.001), proximally located (76.7% vs. 34.5%, p = 0.001), more high mucin-containing tumor (10.0% vs. 5.1%, p = 0.001) and female predominance (56.7% vs. 30.2%, p = 0.001). In multivariate analysis, MSI-H is an independent factor for better overall survival (HR, 0.459; 95% CI, 0.241–0.872, p = 0.017).

Conclusions

Based on the hospital-based study, MSI-H colon cancers demonstrated distinguished clinicopathologic features from MSI-L/S colon cancers. MSI-H is an independent favorable prognostic factor for overall survival in colon cancer.

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Title: Clinicopathologic features and prognostic analysis of MSI-high colon cancer
Authors: Chun-Chi Lin
Yi-Ling Lai
Tzu-Chen Lin
Wei-Shone Chen
Jeng-Kai Jiang
Shung-Haur Yang
Huann-Sheng Wang
Yuan-Tzu Lan
Wen-Yih Liang
Hui-Mei Hsu
Jen-Kou Lin
Shih-Ching Chang
Publication date: 01-03-2012
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 3/2012
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-011-1341-2

At a glance: The STEP trials

Springer Medicine

Clinicopathologic features and prognostic analysis of MSI-high colon cancer

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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