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International Journal of Colorectal Disease

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01-08-2011 | Original Article

Effect of preoperative neutrophil–lymphocyte ratio on the surgical outcomes of stage II colon cancer patients who do not receive adjuvant chemotherapy

Authors: Hsin-Yuan Hung, Jinn-Shiun Chen, Chien Yuh Yeh, Chung-Rong Changchien, Reiping Tang, Pao-Shiu Hsieh, Wen-Sy Tasi, Jeng-Fu You, Yau-Tong You, Chung-Wei Fan, Jeng-Yi Wang, Jy-Ming Chiang

Published in: International Journal of Colorectal Disease | Issue 8/2011

Abstract

Background and aims

Selection of appropriate stage II colon cancer patients for adjuvant chemotherapy is critical for improving survival outcome. With the aim of identifying more high risk factors for stage II colon cancer, this study aimed to determine whether the neutrophil–lymphocyte ratio (NLR) is a predictor of surgical outcomes in patients with stage II colon cancer who do not receive adjuvant chemotherapy.

Materials and methods

We enrolled 1,040 stage II colon cancer patients who had undergone colectomy at a single institution between January 1995 and December 2005 and did not receive adjuvant chemotherapy.

Results

Of these 1,040 patients, 785 (75.5%) patients had a normal NLR and 255 (24.5%) had an elevated NLR. Those with an elevated NLR included patients ≥65 years, T4b cancer, carcinoembryonic antigen ≥5 ng/mL, and tumor obstruction or perforation. Patients with an elevated NLR had a significantly worse overall survival (OS) and worse disease-free survival (DFS) than did patients with a normal NLR. Cox regression analysis revealed that elevated NLR was an independent predictor of OS (P=0.012) but not DFS (P=0.255).

Conclusion

An elevated NLR is an independent predictor of OS but not DFS in stage II colon cancer patients who did not receive adjuvant chemotherapy. Preoperative NLR measurement in stage II colon cancer patients may be a simple method for identifying patients with a poor prognosis who can be enrolled in further trials of adjuvant chemotherapy.

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Title: Effect of preoperative neutrophil–lymphocyte ratio on the surgical outcomes of stage II colon cancer patients who do not receive adjuvant chemotherapy
Authors: Hsin-Yuan Hung
Jinn-Shiun Chen
Chien Yuh Yeh
Chung-Rong Changchien
Reiping Tang
Pao-Shiu Hsieh
Wen-Sy Tasi
Jeng-Fu You
Yau-Tong You
Chung-Wei Fan
Jeng-Yi Wang
Jy-Ming Chiang
Publication date: 01-08-2011
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 8/2011
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-011-1192-x

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Effect of preoperative neutrophil–lymphocyte ratio on the surgical outcomes of stage II colon cancer patients who do not receive adjuvant chemotherapy

Abstract

Background and aims

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background and aims

Materials and methods

Results

Conclusion

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