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International Journal of Colorectal Disease

Published in:

01-02-2007 | Original Article

Microsatellite instability did not predict individual survival of unselected patients with colorectal cancer

Authors: C. Lamberti, S. Lundin, M. Bogdanow, C. Pagenstecher, N. Friedrichs, R Büttner, T. Sauerbruch

Published in: International Journal of Colorectal Disease | Issue 2/2007

Abstract

Introduction

High microsatellite instability (MSI-H) occurs in about 15% of colorectal cancers (CRC) and clinical as well as pathological features differ from tumours exhibiting low microsatellite instability (MSI-L) or microsatellite stability (MSS). Conflicting data exists about the relevance of MSI in predicting the prognosis and benefit of 5-fluorouracil (5-FU) based chemotherapy in patients with CRC. We investigated the usefulness of MSI as a predictor of distinct clinical attributes influencing recurrence rate and disease-free survival (DFS) subject to the use of adjuvant or palliative chemotherapy with 5-FU in stage II- stage IV CRC.

Methods

We collected data and tumours of 416 consecutive stage I to IV CRC patients from 2000 to 2002, and followed them for a median time of 33 months. Microsatellite loci recommended by the National Cancer Institute were analysed. Cox proportional hazard modelling was used to compare clinical data and survival as well as associations for MSI and 5-FU treatment status of patients with MSI-H, MSI-L or MSS CRC.

Results

We identified 52 MSI-H (13%), 21 MSI-L (5%) and 343 MSS (82%) tumours. CRC with MSI-H tended to have a decreased likelihood of metastasising to regional lymph nodes (p=0.055), whilst age of diagnosis and tumour location did not differ. In an analysis that did not take into account the use of chemotherapy, univariate and multivariate analyses failed to show a difference between MSI-H and MSS groups with respect to disease-free and overall survival. Furthermore, survival under application of 5-FU did not correlate with MSI status.

Conclusion

No clear influence of MSI status on overall survival and response to 5-FU chemotherapy was found.

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Carethers JM, Smith EJ, Behling CA, Nguyen L, Tajima A, Doctolero RT, Cabrera BL, Goel A, Arnold CA, Miyai K, Boland CR, Chauhan DP, Fink D, Nebel S, Bresalier RS, Howell SB (2004) Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer mismatch repair proficiency and in vitro response to 5-fluorouracil. Gastroenterology 126:394–401CrossRefPubMed

Title: Microsatellite instability did not predict individual survival of unselected patients with colorectal cancer
Authors: C. Lamberti
S. Lundin
M. Bogdanow
C. Pagenstecher
N. Friedrichs
R Büttner
T. Sauerbruch
Publication date: 01-02-2007
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 2/2007
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-006-0131-8

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Microsatellite instability did not predict individual survival of unselected patients with colorectal cancer

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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