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International Journal of Colorectal Disease

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01-11-2005 | Original Article

Short- and-long term results of intraoperative radiofrequency ablation of liver metastases

Authors: G. Navarra, A. Ayav, J.-C. Weber, S. L. Jensen, C. Smadga, J. P. Nicholls, N. A. Habib, L. R. Jiao

Published in: International Journal of Colorectal Disease | Issue 6/2005

Abstract

Background

Surgical resection is the only therapeutic option with curative effect on malignant liver tumours, but in over 70% of cases, this is not a feasible option. A prospective study was performed to assess the short- and long-term effects of intraoperative radiofrequency ablation on unresectable liver metastases.

Patients

Between 1997 and 2001, 57 patients (mean age 61.9 years; range 31–83 years) with 297 unresectable liver metastases (colorectal adenocarcinoma, n=38; carcinoid tumour, n=4; malignant melanoma, n=3; other metastases, n=12) underwent intraoperative radiofrequency ablation.

Results

No mortality was observed in patients managed solely with radiofrequency ablation. Eight postoperative complications occurred in eight patients (14%). Three occurred when radiofrequency ablation was combined with resection. Of the 33 patients completely ablated, 30 patients are still alive and 21 are disease-free after a median follow-up of 18.1 months (range 2–43). Ten patients underwent more than one intraoperative radiofrequency ablation episode. Overall survival was 72.5% at 1 year and 52.5% at 3 years. Complete ablation and the number of lesions were significant independent prognostic factors for survival, with p<0.001 and p<0.0001, respectively.

Conclusion

Radiofrequency ablation is a safe and effective option for patients with inoperable liver metastases without extra hepatic disease. Prospective controlled trials comparing the results of different treatments are required to assess which patients will benefit best from this emerging new treatment.

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Title: Short- and-long term results of intraoperative radiofrequency ablation of liver metastases
Authors: G. Navarra
A. Ayav
J.-C. Weber
S. L. Jensen
C. Smadga
J. P. Nicholls
N. A. Habib
L. R. Jiao
Publication date: 01-11-2005
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 6/2005
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-005-0743-4

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Short- and-long term results of intraoperative radiofrequency ablation of liver metastases

Abstract

Background

Patients

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Patients

Results

Conclusion

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