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01-10-2017 | Original Article

Prognostic factors indicating survival with native liver after Kasai procedure for biliary atresia

Authors: Juma Obayashi, Kohei Kawaguchi, Shutaro Manabe, Hideki Nagae, Munechika Wakisaka, Junki Koike, Masayuki Takagi, Hiroaki Kitagawa

Published in: Pediatric Surgery International | Issue 10/2017

Abstract

Background

The number of the bile ducts in the portal canal/measured surface area of the portal canal (BDP ratio) indicates prognosis in biliary atresia (BA), as does an elevated cytokeratin 7 positivity percentage (PCK7). We compared these two markers.

Methods

We reviewed 32 BA cases undergoing Kasai operation from 1976 to 2016 with >5 portal canals in biopsy samples. Group I required liver transplantation or died within a year of operation (n = 8). Group II survived with their native liver (n = 24). We determined the BDP ratio (10²/mm²) and PCK7 (%), subdividing patients into three groups by their age at operation: Group A ≤60 days (n = 6, 1 Group I), 60< Group B ≤90days (n = 16, 5 Group I), Group C >90 days (n = 10, 2 Group I).

Results

PCK7 (%) was 2.71 ± 1.87 in Group I and 4.25 ± 2.56 in Group II (p = 0.13). BDP ratio (10²/mm²) was 1.19 ± 0.424 in Group I and 1.64 ± 0.534 in Group II (p = 0.04). Both markers were higher in Group C than in Group A or B (p < 0.01).

Conclusion

The BDP ratio is a better prognostic indicator than PCK7 in BA.

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Title: Prognostic factors indicating survival with native liver after Kasai procedure for biliary atresia
Authors: Juma Obayashi
Kohei Kawaguchi
Shutaro Manabe
Hideki Nagae
Munechika Wakisaka
Junki Koike
Masayuki Takagi
Hiroaki Kitagawa
Publication date: 01-10-2017
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Surgery International / Issue 10/2017
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-017-4135-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Prognostic factors indicating survival with native liver after Kasai procedure for biliary atresia

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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