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01-09-2016 | Original Article

Relation between amount of bile ducts in portal canal and outcomes in biliary atresia

Authors: Juma Obayashi, Kunihide Tanaka, Kei Ohyama, Shutaro Manabe, Hideki Nagae, Hideki Shima, Hideaki Sato, Shigeyuki Furuta, Munechika Wakisaka, Junki Koike, Masayuki Takagi, Hiroaki Kitagawa

Published in: Pediatric Surgery International | Issue 9/2016

Abstract

Background

There is no good prognostic indicator for biliary atresia (BA). We reviewed liver biopsies taken during the initial procedure to find a prognostic marker.

Methods

Thirty-two BA cases underwent Kasai operation from 1976 to 2009. We compared two groups at 1, 3, and 9 years. Group A required liver transplantation or died. Group B survived with their native liver. Biopsies were analyzed for liver fibrosis, portal-central vein bridging (P–C bridging), ductal plate malformation (DPM) and the number of the bile ducts in portal canal/measured surface area of the portal canal (BDP ratio). Statistical comparisons of the multiple data were evaluated by Mann–Whitney U test, Student’s t test and Pearson’s Chi-square test. Regression analysis with P < 0.05 was considered significant.

Results

BDP ratios (/mm²) were 2.4 ± 1.5 in Group A1 (n = 9) vs 4.6 ± 2.4 in Group B1 (n = 23) (P = 0.01); 2.6 ± 1.4 in Group A3 (n = 14) vs 5.1 ± 2.5 in Group B3 (n = 18) (P < 0.01), 3.0 ± 2.2 in Group A9 (n = 15) vs 4.9 ± 2.5 in Group B9 (n = 15) (P < 0.05). There was no significant difference in any other finding.

Conclusion

The BDP ratio is a sound prognostic indicator in BA.

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Title: Relation between amount of bile ducts in portal canal and outcomes in biliary atresia
Authors: Juma Obayashi
Kunihide Tanaka
Kei Ohyama
Shutaro Manabe
Hideki Nagae
Hideki Shima
Hideaki Sato
Shigeyuki Furuta
Munechika Wakisaka
Junki Koike
Masayuki Takagi
Hiroaki Kitagawa
Publication date: 01-09-2016
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Surgery International / Issue 9/2016
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-016-3941-y

At a glance: The STEP trials

Springer Medicine

Relation between amount of bile ducts in portal canal and outcomes in biliary atresia

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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