Skip to main content
Top
Published in: Pediatric Surgery International 7/2016

01-07-2016 | Review Article

Management of fetal teratomas

Authors: Jose L. Peiró, Lourenço Sbragia, Federico Scorletti, Foong Y. Lim, Aimen Shaaban

Published in: Pediatric Surgery International | Issue 7/2016

Login to get access

Abstract

Fetal teratomas are the most common tumors diagnosed prenatally. The majority of these tumors are benign and cured by complete resection of the mass during the neonatal period. Prenatal diagnosis has improved the perinatal management of these lesions and especially for the teratomas that might benefit from fetal intervention. A comprehensive prenatal evaluation including conventional ultrasounds, Doppler, echocardiography and fetal MRI, is essential for an effective counseling and perinatal management. Antenatal counseling helps the parents to better understand the natural history, fetal intervention, and perinatal management of these tumors, which differ dramatically depending on their size and location. Fetal surgical debulking improves survival in cases of sacrococcygeal teratoma with cardiac decompensation. Additionally, the use of an EXIT procedure reduces the morbidity and mortality if a complicated delivery in cases of cervical and mediastinal teratomas. Here, we offer an overview of all fetal teratomas and their recommended management, with emphasis on in utero treatment options.
Literature
1.
go back to reference Bader JL, Miller RW (1979) US cancer incidence and mortality in the first year of life. Am J Dis Child 133:157–159PubMed Bader JL, Miller RW (1979) US cancer incidence and mortality in the first year of life. Am J Dis Child 133:157–159PubMed
2.
go back to reference Moore SW, Satgé D, Sasco AJ et al (2003) The epidemiology of neonatal tumours. Report of an international working group. Pediatr Surg Int 19:509–519PubMedCrossRef Moore SW, Satgé D, Sasco AJ et al (2003) The epidemiology of neonatal tumours. Report of an international working group. Pediatr Surg Int 19:509–519PubMedCrossRef
3.
5.
go back to reference Thilaganathan B, Sairam SH, Papageorghiou AT et al (2007) Problem based obstetric ultrasound. Informa UK Ltd, London, pp 43–50CrossRef Thilaganathan B, Sairam SH, Papageorghiou AT et al (2007) Problem based obstetric ultrasound. Informa UK Ltd, London, pp 43–50CrossRef
6.
go back to reference Heerema-McKenney A, Harrison MR, Bratton B et al (2005) Congenital teratoma: a clinicopathologic study of 22 fetal and neonatal tumors. Am J Surg Pathol 29:29–38PubMedCrossRef Heerema-McKenney A, Harrison MR, Bratton B et al (2005) Congenital teratoma: a clinicopathologic study of 22 fetal and neonatal tumors. Am J Surg Pathol 29:29–38PubMedCrossRef
7.
go back to reference Sbragia L, Paek BW, Feldstein VA et al (2001) Outcome of prenatally diagnosed solid fetal tumors. J Pediatr Surg 36:1244–1247PubMedCrossRef Sbragia L, Paek BW, Feldstein VA et al (2001) Outcome of prenatally diagnosed solid fetal tumors. J Pediatr Surg 36:1244–1247PubMedCrossRef
8.
go back to reference Peiro JL, Sbragia L, Scorletti F, Lim FY (2015) Perinatal management of fetal tumors. Curr Pediatr Rev 11:151–163PubMedCrossRef Peiro JL, Sbragia L, Scorletti F, Lim FY (2015) Perinatal management of fetal tumors. Curr Pediatr Rev 11:151–163PubMedCrossRef
9.
go back to reference Virchow R (1869) Ueber Die Sakralgeschwulst Des Schliewener Kindes. Klin Wochenschr 46:132 Virchow R (1869) Ueber Die Sakralgeschwulst Des Schliewener Kindes. Klin Wochenschr 46:132
12.
go back to reference Isaacs H Jr (1997) Germ cell tumors. Tumors of the fetus and newborn. The series major problems in pathology. Saunders, Philadelphia, pp 15–38 Isaacs H Jr (1997) Germ cell tumors. Tumors of the fetus and newborn. The series major problems in pathology. Saunders, Philadelphia, pp 15–38
13.
go back to reference Teilum G (1965) Classification of endodermal sinus tumour (mesoblastoma vitellinum) and so called “embryonal carcinoma” of the ovary. Acta Pathol Microbiol Scand 64:407–429PubMed Teilum G (1965) Classification of endodermal sinus tumour (mesoblastoma vitellinum) and so called “embryonal carcinoma” of the ovary. Acta Pathol Microbiol Scand 64:407–429PubMed
14.
go back to reference Sobis H, Vandeputte M (1975) Sequential morphological study of teratomas derived from displaced yolk sac. Dev Biol 45:276–290PubMedCrossRef Sobis H, Vandeputte M (1975) Sequential morphological study of teratomas derived from displaced yolk sac. Dev Biol 45:276–290PubMedCrossRef
15.
go back to reference Linder D, McCaw BK, Hecht F (1975) Parthenogenic origin of benign ovarian teratomas. N Engl J Med 292:63–66PubMedCrossRef Linder D, McCaw BK, Hecht F (1975) Parthenogenic origin of benign ovarian teratomas. N Engl J Med 292:63–66PubMedCrossRef
16.
go back to reference Billmire DF, Grosfeld JL (1986) Teratomas in childhood: analysis of 142 cases. J Pediatr Surg 21:548–551PubMedCrossRef Billmire DF, Grosfeld JL (1986) Teratomas in childhood: analysis of 142 cases. J Pediatr Surg 21:548–551PubMedCrossRef
17.
18.
go back to reference Zakaria MA (1986) Epignathus (congenital teratoma of the hard palate): a case report. Br J Oral Maxillofac Surg 24:272–276PubMedCrossRef Zakaria MA (1986) Epignathus (congenital teratoma of the hard palate): a case report. Br J Oral Maxillofac Surg 24:272–276PubMedCrossRef
19.
go back to reference Hoeffel CC, Nguyen KQ, Phan HT et al (2000) Fetus in fetu: a case report and literature review. Pediatrics 105:1335–1344PubMedCrossRef Hoeffel CC, Nguyen KQ, Phan HT et al (2000) Fetus in fetu: a case report and literature review. Pediatrics 105:1335–1344PubMedCrossRef
20.
go back to reference Norris HJ, Zirkin HJ, Benson WL (1976) Immature (malignant) teratoma of the ovary. Cancer 37:2359–2372PubMedCrossRef Norris HJ, Zirkin HJ, Benson WL (1976) Immature (malignant) teratoma of the ovary. Cancer 37:2359–2372PubMedCrossRef
22.
go back to reference Marina NM, Cushing B, Giller R et al (1999) Complete surgical excision is effective treatment for children with immature teratomas with or without malignant elements: a Pediatric Oncology Group/Children’s Cancer Group Intergroup Study. J Clin Oncol 17:2137–2143PubMed Marina NM, Cushing B, Giller R et al (1999) Complete surgical excision is effective treatment for children with immature teratomas with or without malignant elements: a Pediatric Oncology Group/Children’s Cancer Group Intergroup Study. J Clin Oncol 17:2137–2143PubMed
24.
go back to reference Gitlin D, Perricelli A, Gitlin GM (1972) Synthesis of alpha-fetoprotein by liver, yolk sac, and gastrointestinal tract of the human conceptus. Cancer Res 32:979–982PubMed Gitlin D, Perricelli A, Gitlin GM (1972) Synthesis of alpha-fetoprotein by liver, yolk sac, and gastrointestinal tract of the human conceptus. Cancer Res 32:979–982PubMed
25.
go back to reference Ruoslahti E, Engvall E, Pekkala A et al (1978) Developmental changes in carbohydrate moiety of human alpha-fetoprotein. Int J Cancer 22:515–520PubMedCrossRef Ruoslahti E, Engvall E, Pekkala A et al (1978) Developmental changes in carbohydrate moiety of human alpha-fetoprotein. Int J Cancer 22:515–520PubMedCrossRef
27.
go back to reference Currarino G, Coln D, Votteler T (1981) Triad of anorectal, sacral, and presacral anomalies. AJR Am J Roentgenol 137:395–398PubMedCrossRef Currarino G, Coln D, Votteler T (1981) Triad of anorectal, sacral, and presacral anomalies. AJR Am J Roentgenol 137:395–398PubMedCrossRef
28.
go back to reference Subbarao P, Bhatnagar V, Mitra DK (1994) The association of sacrococcygeal teratoma with high anorectal and genital malformations. Aust NZ J Surg 64:214–215CrossRef Subbarao P, Bhatnagar V, Mitra DK (1994) The association of sacrococcygeal teratoma with high anorectal and genital malformations. Aust NZ J Surg 64:214–215CrossRef
30.
go back to reference Tsuchida Y, Hasegawa H (1983) The diagnostic value of alpha-fetoprotein in infants and children with teratomas: a questionnaire survey in Japan. J Pediatr Surg 18:152–155PubMedCrossRef Tsuchida Y, Hasegawa H (1983) The diagnostic value of alpha-fetoprotein in infants and children with teratomas: a questionnaire survey in Japan. J Pediatr Surg 18:152–155PubMedCrossRef
31.
go back to reference Harms D, Zahn S, Göbel U et al (2006) Pathology and molecular biology of teratomas in childhood and adolescence. Klin Padiatr 218:296–302PubMedCrossRef Harms D, Zahn S, Göbel U et al (2006) Pathology and molecular biology of teratomas in childhood and adolescence. Klin Padiatr 218:296–302PubMedCrossRef
32.
go back to reference Stevens LC (1970) Experimental production of testicular teratomas in mice of strains 129, A/He, and their F1 hybrids. J Natl Cancer Inst 44:923–929PubMed Stevens LC (1970) Experimental production of testicular teratomas in mice of strains 129, A/He, and their F1 hybrids. J Natl Cancer Inst 44:923–929PubMed
33.
go back to reference Andrews PW, Gokhale PJ (2011) From teratomas to embryonic stem cells: discovering pluripotency. Nature Reviews Molecular Cell Biology 12 (Poster) Andrews PW, Gokhale PJ (2011) From teratomas to embryonic stem cells: discovering pluripotency. Nature Reviews Molecular Cell Biology 12 (Poster)
35.
36.
go back to reference Pantoja E, Liobet R, Gonsales-Flores B (1976) Retroperitoneal teratoma: historical review. J Urol 115:520–523PubMed Pantoja E, Liobet R, Gonsales-Flores B (1976) Retroperitoneal teratoma: historical review. J Urol 115:520–523PubMed
37.
go back to reference Altman RP, Randolph JG, Lilly JR (1973) Sacrococcygeal teratoma: american Academy of Pediatrics Surgical Section Survey-1973. J Pediatr Surg 9:389–398CrossRef Altman RP, Randolph JG, Lilly JR (1973) Sacrococcygeal teratoma: american Academy of Pediatrics Surgical Section Survey-1973. J Pediatr Surg 9:389–398CrossRef
38.
39.
go back to reference Rescorla FJ, Sawin RS, Coran AG et al (1998) Long-term outcome for infants with sacrococcygeal teratoma: a report from the Children’s Cancer Group. J Pediatr Surg 33:171–176PubMedCrossRef Rescorla FJ, Sawin RS, Coran AG et al (1998) Long-term outcome for infants with sacrococcygeal teratoma: a report from the Children’s Cancer Group. J Pediatr Surg 33:171–176PubMedCrossRef
40.
go back to reference Noseworthy J, Lack EE, Kozakewich HPW et al (1981) Sacrococcygeal germ cell tumors in childhood: an updated experience with 118 patients. J Pediatr Surg 16:358–364PubMedCrossRef Noseworthy J, Lack EE, Kozakewich HPW et al (1981) Sacrococcygeal germ cell tumors in childhood: an updated experience with 118 patients. J Pediatr Surg 16:358–364PubMedCrossRef
42.
go back to reference Harrison MR, Bjordal RI, Langmark F et al (1978) Congenital diaphragmatic hernia: the hidden mortality. J Pediatr Surg 13:227–230PubMedCrossRef Harrison MR, Bjordal RI, Langmark F et al (1978) Congenital diaphragmatic hernia: the hidden mortality. J Pediatr Surg 13:227–230PubMedCrossRef
43.
go back to reference Bond SJ, Harrison MR, Schmidt KG et al (1990) Death due to high-output cardiac failure in fetal sacrococcygeal teratoma. J Pediatr Surg 25:1287–1291PubMedCrossRef Bond SJ, Harrison MR, Schmidt KG et al (1990) Death due to high-output cardiac failure in fetal sacrococcygeal teratoma. J Pediatr Surg 25:1287–1291PubMedCrossRef
44.
go back to reference Grosfeld JL, Ballantine TV, Lowe D et al (1976) Benign and malignant teratomas in children: analysis of 85 patients. Surgery 80:297–305PubMed Grosfeld JL, Ballantine TV, Lowe D et al (1976) Benign and malignant teratomas in children: analysis of 85 patients. Surgery 80:297–305PubMed
45.
go back to reference Issacs HJ (1997) Tumors. In: Gilbert-Barnes E (ed) Potter’s pathology of the fetus and newborn. Mosby-Year Book, St Louis, pp 1242–1339 Issacs HJ (1997) Tumors. In: Gilbert-Barnes E (ed) Potter’s pathology of the fetus and newborn. Mosby-Year Book, St Louis, pp 1242–1339
46.
go back to reference Borsellino A, Zaccara A, Nahom A et al (2006) False-positive rate in prenatal diagnosis of surgical anomalies. J Pediatr Surg 41:826–829PubMedCrossRef Borsellino A, Zaccara A, Nahom A et al (2006) False-positive rate in prenatal diagnosis of surgical anomalies. J Pediatr Surg 41:826–829PubMedCrossRef
47.
go back to reference McEwing R, Hayward C, Furness M (2003) Foetal cystic abdominal masses. Australas Radiol 47:101–110PubMedCrossRef McEwing R, Hayward C, Furness M (2003) Foetal cystic abdominal masses. Australas Radiol 47:101–110PubMedCrossRef
48.
go back to reference Hedrick HL, Flake AW, Crombleholme TM et al (2004) Sacrococcygeal teratoma: prenatal assessment, fetal intervention, and outcome. J Pediatr Surg 39:430–438PubMedCrossRef Hedrick HL, Flake AW, Crombleholme TM et al (2004) Sacrococcygeal teratoma: prenatal assessment, fetal intervention, and outcome. J Pediatr Surg 39:430–438PubMedCrossRef
49.
go back to reference Flake AW, Harrison MR, Adzick NS et al (1986) Fetal sacrococcygeal teratoma. J Pediatr Surg 21:563–566PubMedCrossRef Flake AW, Harrison MR, Adzick NS et al (1986) Fetal sacrococcygeal teratoma. J Pediatr Surg 21:563–566PubMedCrossRef
51.
go back to reference Benachi A, Durin L, Vasseur Maurer S et al (2006) Prenatally diagnosed sacrococcygeal teratoma: a prognostic classification. J Pediatr Surg 41:1517–1521PubMedCrossRef Benachi A, Durin L, Vasseur Maurer S et al (2006) Prenatally diagnosed sacrococcygeal teratoma: a prognostic classification. J Pediatr Surg 41:1517–1521PubMedCrossRef
54.
58.
go back to reference Adzick NS, Crombleholme TM, Morgan MA et al (1997) A rapidly growing fetal teratoma. Lancet 349:538PubMedCrossRef Adzick NS, Crombleholme TM, Morgan MA et al (1997) A rapidly growing fetal teratoma. Lancet 349:538PubMedCrossRef
59.
go back to reference Graf JL, Albanese CT, Jennings RW et al (2000) Successful fetal sacrococcygeal teratoma resection in a hydropic fetus. J Pediatr Surg 35:1489–1491PubMedCrossRef Graf JL, Albanese CT, Jennings RW et al (2000) Successful fetal sacrococcygeal teratoma resection in a hydropic fetus. J Pediatr Surg 35:1489–1491PubMedCrossRef
60.
go back to reference Flake AW (1993) Fetal sacrococcygeal teratoma. Semin Pediatr Surg 2:113–1120PubMed Flake AW (1993) Fetal sacrococcygeal teratoma. Semin Pediatr Surg 2:113–1120PubMed
62.
go back to reference Harrison MR, Adzick NS (1993) Fetal surgical techniques. Semin Pediatr Surg 2:136–142PubMed Harrison MR, Adzick NS (1993) Fetal surgical techniques. Semin Pediatr Surg 2:136–142PubMed
64.
go back to reference Paek BW, Jennings RW, Harrison MR et al (2001) Radiofrequency ablation of human fetal sacrococcygeal teratoma. Am J Obstet Gynecol 184:503–507PubMedCrossRef Paek BW, Jennings RW, Harrison MR et al (2001) Radiofrequency ablation of human fetal sacrococcygeal teratoma. Am J Obstet Gynecol 184:503–507PubMedCrossRef
65.
go back to reference Lam YH, Tang MH, Shek TW (2002) Thermocoagulation of fetal sacrococcygeal teratoma. Prenat Diagn 22:99–101PubMedCrossRef Lam YH, Tang MH, Shek TW (2002) Thermocoagulation of fetal sacrococcygeal teratoma. Prenat Diagn 22:99–101PubMedCrossRef
66.
go back to reference Ibrahim D, Ho E, Scherl SA et al (2003) Newborn with an open posterior hip dislocation and sciatic nerve injury after intrauterine radiofrequency ablation of a sacrococcygeal teratoma. J Pediatr Surg 38:248–250PubMedCrossRef Ibrahim D, Ho E, Scherl SA et al (2003) Newborn with an open posterior hip dislocation and sciatic nerve injury after intrauterine radiofrequency ablation of a sacrococcygeal teratoma. J Pediatr Surg 38:248–250PubMedCrossRef
68.
go back to reference Bullard KM, Harrison MR (1995) Before the horse is out of the barn: fetal surgery for hydrops. Semin Perinatol 19:462–473PubMedCrossRef Bullard KM, Harrison MR (1995) Before the horse is out of the barn: fetal surgery for hydrops. Semin Perinatol 19:462–473PubMedCrossRef
71.
go back to reference Merchant AM, Hedrick HL, Johnson MP et al (2005) Management of fetal mediastinal teratoma. J Pediatr Surg 40:228–231PubMedCrossRef Merchant AM, Hedrick HL, Johnson MP et al (2005) Management of fetal mediastinal teratoma. J Pediatr Surg 40:228–231PubMedCrossRef
72.
go back to reference Azizkhan RG, Haase GM, Applebaum H et al (1995) Diagnosis, management, and outcome of cervicofacial teratomas in neonates: a Children’s Cancer Group study. J Pediatr Surg 30:312–316PubMedCrossRef Azizkhan RG, Haase GM, Applebaum H et al (1995) Diagnosis, management, and outcome of cervicofacial teratomas in neonates: a Children’s Cancer Group study. J Pediatr Surg 30:312–316PubMedCrossRef
73.
go back to reference Raveh E, Papsin BC, Farine D et al (1998) The outcome after perinatal management of infants with potential airway obstruction. Int J Pediatr Otorhinolaryngol 46:207–214PubMedCrossRef Raveh E, Papsin BC, Farine D et al (1998) The outcome after perinatal management of infants with potential airway obstruction. Int J Pediatr Otorhinolaryngol 46:207–214PubMedCrossRef
75.
go back to reference Byard RW, Jimenez CL, Carpenter BF et al (1990) Congenital teratomas of the neck and nasopharynx: a clinical and pathological study of 18 cases. J Paediatr Child Health 26:12–16PubMedCrossRef Byard RW, Jimenez CL, Carpenter BF et al (1990) Congenital teratomas of the neck and nasopharynx: a clinical and pathological study of 18 cases. J Paediatr Child Health 26:12–16PubMedCrossRef
76.
go back to reference Bergé SJ, von Lindern JJ, Appel T et al (2004) Diagnosis and management of cervical teratomas. Br J Oral Maxillofac Surg 42:41–45PubMedCrossRef Bergé SJ, von Lindern JJ, Appel T et al (2004) Diagnosis and management of cervical teratomas. Br J Oral Maxillofac Surg 42:41–45PubMedCrossRef
77.
go back to reference Goldstein I, Drugan A (2005) Congenital cervical teratoma, associated with agenesis of corpus callosum and a subarachnoid cyst. Prenat Diagn 25:439–441 Goldstein I, Drugan A (2005) Congenital cervical teratoma, associated with agenesis of corpus callosum and a subarachnoid cyst. Prenat Diagn 25:439–441
78.
go back to reference Chiang YC, Shih JC, Peng SS et al (2006) Tongue teratoma: a rare form of fetal extragonadal teratoma diagnosed at 30 weeks’ gestation. Ultrasound Obstet Gynecol 28:737–741PubMedCrossRef Chiang YC, Shih JC, Peng SS et al (2006) Tongue teratoma: a rare form of fetal extragonadal teratoma diagnosed at 30 weeks’ gestation. Ultrasound Obstet Gynecol 28:737–741PubMedCrossRef
79.
go back to reference Hassan S, Sidek DS, Shah Jihan WD et al (2007) Massive lingual teratoma in a neonate. Singapore Med J 48:e212–e214PubMed Hassan S, Sidek DS, Shah Jihan WD et al (2007) Massive lingual teratoma in a neonate. Singapore Med J 48:e212–e214PubMed
80.
go back to reference Celik M, Akkaya H, Arda IS et al (2006) Congenital teratoma of the tongue: a case report and review of the literature. J Pediatr Surg 41:25–28CrossRef Celik M, Akkaya H, Arda IS et al (2006) Congenital teratoma of the tongue: a case report and review of the literature. J Pediatr Surg 41:25–28CrossRef
81.
go back to reference Yoon JH, Kim J, Park C (2002) Congenital immature teratoma of the tongue: an autopsy case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94:741–745PubMedCrossRef Yoon JH, Kim J, Park C (2002) Congenital immature teratoma of the tongue: an autopsy case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94:741–745PubMedCrossRef
86.
go back to reference Onyekwe LO, Onwuegbuna AN, Emejulu JK (2010) Congenital orbital teratoma. Niger J Clin Pract 13:338–340PubMed Onyekwe LO, Onwuegbuna AN, Emejulu JK (2010) Congenital orbital teratoma. Niger J Clin Pract 13:338–340PubMed
87.
go back to reference Gnanaraj L, Skibell BC, Coret-Simon J et al (2005) Massive congenital orbital teratoma. Ophthal Plast Reconstr Surg 21:445–447PubMedCrossRef Gnanaraj L, Skibell BC, Coret-Simon J et al (2005) Massive congenital orbital teratoma. Ophthal Plast Reconstr Surg 21:445–447PubMedCrossRef
88.
go back to reference Maddali MM, Al Balushi FK, Waje ND (2016) Elephant trunk-like teratoma of the face with compromised airway in an infant with complex congenital cardiac defects: an anesthetic challenge. A A Case Rep 6(3):52–55PubMedCrossRef Maddali MM, Al Balushi FK, Waje ND (2016) Elephant trunk-like teratoma of the face with compromised airway in an infant with complex congenital cardiac defects: an anesthetic challenge. A A Case Rep 6(3):52–55PubMedCrossRef
89.
go back to reference Castillo F, Peiró JL, Carreras E et al (2007) The exit procedure (ex-utero intrapartum treatment): management of giant fetal cervical teratoma. J Perinat Med 35:553–555PubMedCrossRef Castillo F, Peiró JL, Carreras E et al (2007) The exit procedure (ex-utero intrapartum treatment): management of giant fetal cervical teratoma. J Perinat Med 35:553–555PubMedCrossRef
90.
go back to reference Bealer JF, Skarsgard ED, Hedrick MH et al (1995) The ‘PLUG’ odyssey: adventures in experimental fetal tracheal occlusion. J Pediatr Surg 30:361–364PubMedCrossRef Bealer JF, Skarsgard ED, Hedrick MH et al (1995) The ‘PLUG’ odyssey: adventures in experimental fetal tracheal occlusion. J Pediatr Surg 30:361–364PubMedCrossRef
91.
go back to reference Harrison MR, Adzick NS, Flake AW et al (1996) Correction of congenital diaphragmatic hernia in utero VIII: response of the hypoplastic lung to tracheal occlusion. J Pediatr Surg 31:1339–1348PubMedCrossRef Harrison MR, Adzick NS, Flake AW et al (1996) Correction of congenital diaphragmatic hernia in utero VIII: response of the hypoplastic lung to tracheal occlusion. J Pediatr Surg 31:1339–1348PubMedCrossRef
92.
go back to reference Mychaliska GB, Bealer JF, Graf JL et al (1997) Operating on placental support: the ex utero intrapartum treatment procedure. J Pediatr Surg 32:227–230PubMedCrossRef Mychaliska GB, Bealer JF, Graf JL et al (1997) Operating on placental support: the ex utero intrapartum treatment procedure. J Pediatr Surg 32:227–230PubMedCrossRef
93.
go back to reference Liechty KW, Crombleholme TM, Flake AW et al (1997) Intrapartum airway management for giant fetal neck masses: the EXIT (ex utero intrapartum treatment) procedure. Am J Obstet Gynecol 177:870–874PubMedCrossRef Liechty KW, Crombleholme TM, Flake AW et al (1997) Intrapartum airway management for giant fetal neck masses: the EXIT (ex utero intrapartum treatment) procedure. Am J Obstet Gynecol 177:870–874PubMedCrossRef
97.
go back to reference Paradies G, Zullino F, Orofino A et al (2013) Mediastinal teratomas in children. Case reports and review of the literature. Ann Ital Chir 84:395–403PubMed Paradies G, Zullino F, Orofino A et al (2013) Mediastinal teratomas in children. Case reports and review of the literature. Ann Ital Chir 84:395–403PubMed
99.
go back to reference Tollens T, Casselman F, Devlieger H et al (1998) Fetal cardiac tamponade due to an intrapericardial teratoma. Ann Thorac Surg 66:559–560PubMedCrossRef Tollens T, Casselman F, Devlieger H et al (1998) Fetal cardiac tamponade due to an intrapericardial teratoma. Ann Thorac Surg 66:559–560PubMedCrossRef
102.
go back to reference Grebille AG, Mitanchez D, Benachi A et al (2003) Pericardial teratoma complicated by hydrops: successful fetal therapy by thoracoamniotic shunting. Prenat Diagn 23:735–739PubMedCrossRef Grebille AG, Mitanchez D, Benachi A et al (2003) Pericardial teratoma complicated by hydrops: successful fetal therapy by thoracoamniotic shunting. Prenat Diagn 23:735–739PubMedCrossRef
103.
go back to reference Sydorak RM, Kelly T, Feldstein VA et al (2002) Prenatal resection of a fetal pericardial teratoma. Fetal Diagn Ther 17:281–285PubMedCrossRef Sydorak RM, Kelly T, Feldstein VA et al (2002) Prenatal resection of a fetal pericardial teratoma. Fetal Diagn Ther 17:281–285PubMedCrossRef
104.
go back to reference Devlieger R, Hindryckx A, Van Mieghem T et al (2009) Therapy for foetal pericardial tumours: survival following in utero shunting, and literature review. Fetal Diagn Ther 25:407–412. doi:10.1159/000236156 PubMedCrossRef Devlieger R, Hindryckx A, Van Mieghem T et al (2009) Therapy for foetal pericardial tumours: survival following in utero shunting, and literature review. Fetal Diagn Ther 25:407–412. doi:10.​1159/​000236156 PubMedCrossRef
106.
go back to reference Bruch SW, Adzick NS, Reiss R et al (1997) Prenatal therapy for pericardial teratomas. J Pediatr Surg 32:1113–1115PubMedCrossRef Bruch SW, Adzick NS, Reiss R et al (1997) Prenatal therapy for pericardial teratomas. J Pediatr Surg 32:1113–1115PubMedCrossRef
107.
go back to reference Bader R, Hornberger LK, Nijmeh LJ et al (2006) Fetal pericardial teratoma: presentation of two cases and review of literature. Am J Perinatol 23:53–58PubMedCrossRef Bader R, Hornberger LK, Nijmeh LJ et al (2006) Fetal pericardial teratoma: presentation of two cases and review of literature. Am J Perinatol 23:53–58PubMedCrossRef
108.
go back to reference Zhou QC, Fan P, Peng QH et al (2004) Prenatal echocardiographic differential diagnosis of fetal cardiac tumors. Ultrasound Obstet Gynecol 23:165–171PubMedCrossRef Zhou QC, Fan P, Peng QH et al (2004) Prenatal echocardiographic differential diagnosis of fetal cardiac tumors. Ultrasound Obstet Gynecol 23:165–171PubMedCrossRef
110.
go back to reference Seker A, Ozek MM (2006) Congenital glioblastoma multiforme. Case report and review of the literature. J Neurosurg 105(6 Suppl):473–479PubMed Seker A, Ozek MM (2006) Congenital glioblastoma multiforme. Case report and review of the literature. J Neurosurg 105(6 Suppl):473–479PubMed
112.
go back to reference Rickert CH, Probst-Cousin S, Louwen F et al (1997) Congenital immature teratoma of the fetal brain. Childs Nerv Syst 13:556–559PubMedCrossRef Rickert CH, Probst-Cousin S, Louwen F et al (1997) Congenital immature teratoma of the fetal brain. Childs Nerv Syst 13:556–559PubMedCrossRef
113.
go back to reference Stranzinger E, Strouse PJ (2008) Ultrasound of the pediatric female pelvis. Semin Ultrasound CT MR 29:98–113PubMedCrossRef Stranzinger E, Strouse PJ (2008) Ultrasound of the pediatric female pelvis. Semin Ultrasound CT MR 29:98–113PubMedCrossRef
114.
go back to reference Heling KS, Chaoui R, Kirchmair F et al (2002) Fetal ovarian cysts: prenatal diagnosis, management and postnatal outcome. Ultrasound Obstet Gynecol 20:47–50PubMedCrossRef Heling KS, Chaoui R, Kirchmair F et al (2002) Fetal ovarian cysts: prenatal diagnosis, management and postnatal outcome. Ultrasound Obstet Gynecol 20:47–50PubMedCrossRef
116.
go back to reference Shih HH, Teng RJ, Yau KI et al (1997) Mature teratoma arising from an intra-abdominal undescended testis presenting as a fetal abdominal mass. Ultrasound Obstet Gynecol 10:209–211PubMedCrossRef Shih HH, Teng RJ, Yau KI et al (1997) Mature teratoma arising from an intra-abdominal undescended testis presenting as a fetal abdominal mass. Ultrasound Obstet Gynecol 10:209–211PubMedCrossRef
117.
go back to reference Siu SS, Leung TN, Leung TY et al (2001) Prenatal diagnosis of intra-abdominal mature testicular teratoma. J Ultrasound Med 20:1257–1260PubMed Siu SS, Leung TN, Leung TY et al (2001) Prenatal diagnosis of intra-abdominal mature testicular teratoma. J Ultrasound Med 20:1257–1260PubMed
120.
go back to reference Führer S, May M, Koch A et al (2005) Intrauterine torsion of a testicular teratoma: a case report. J Perinatol 25:220–222PubMedCrossRef Führer S, May M, Koch A et al (2005) Intrauterine torsion of a testicular teratoma: a case report. J Perinatol 25:220–222PubMedCrossRef
121.
go back to reference Al-Arfaj AA, El-Shawarby MA, Al-Mulhim FA et al (2003) Mesenteric cystic teratoma in children. Saudi Med J 24:1388–1390PubMed Al-Arfaj AA, El-Shawarby MA, Al-Mulhim FA et al (2003) Mesenteric cystic teratoma in children. Saudi Med J 24:1388–1390PubMed
122.
go back to reference Wagner N, Kagan KO, Warmann SW et al (2009) Prenatal diagnosis and management of a fetal intra-abdominal teratoma: a case report and review of the literature. Fetal Diagn Ther 26:170–172. doi:10.1159/000255169 PubMedCrossRef Wagner N, Kagan KO, Warmann SW et al (2009) Prenatal diagnosis and management of a fetal intra-abdominal teratoma: a case report and review of the literature. Fetal Diagn Ther 26:170–172. doi:10.​1159/​000255169 PubMedCrossRef
124.
go back to reference Gatcombe HG, Assikis V, Kooby D et al (2004) Primary retroperitoneal teratomas: a review of the literature. J Surg Oncol 86:107–113PubMedCrossRef Gatcombe HG, Assikis V, Kooby D et al (2004) Primary retroperitoneal teratomas: a review of the literature. J Surg Oncol 86:107–113PubMedCrossRef
125.
go back to reference Woodward PJ, Sohaey R, Kennedy A et al (2005) From the archives of the AFIP: a comprehensive review of fetal tumors with pathologic correlation. Radiographics 25:215–242PubMedCrossRef Woodward PJ, Sohaey R, Kennedy A et al (2005) From the archives of the AFIP: a comprehensive review of fetal tumors with pathologic correlation. Radiographics 25:215–242PubMedCrossRef
126.
go back to reference Choudhury SR, Debnath PR, Pant N et al (2013) Congenital immature teratoma of the retroperitoneum. J Neonatal Surg 1(2):33 Choudhury SR, Debnath PR, Pant N et al (2013) Congenital immature teratoma of the retroperitoneum. J Neonatal Surg 1(2):33
127.
go back to reference Devesa R, Muñoz A, Torrents M et al (1997) Prenatal ultrasonographic findings of intra-abdominal cystic lymphangioma: a case report. J Clin Ultrasound 25:330–332PubMedCrossRef Devesa R, Muñoz A, Torrents M et al (1997) Prenatal ultrasonographic findings of intra-abdominal cystic lymphangioma: a case report. J Clin Ultrasound 25:330–332PubMedCrossRef
129.
go back to reference Li Y, Zhong Z, Zhao X (2011) Primary mature teratoma presenting as an adrenal tumor in a child. Urology 78:689–691. doi:10.1016/j.urology.2010.12.022 Li Y, Zhong Z, Zhao X (2011) Primary mature teratoma presenting as an adrenal tumor in a child. Urology 78:689–691. doi:10.1016/j.urology.2010.12.022
130.
go back to reference Nadeem M, Ather MH, Sulaiman MN et al (2015) “Looks can be deceiving”: adrenal teratoma causing diagnostic difficulty. Case Rep Urol 2015:232591. doi:10.1155/2015/232591 Nadeem M, Ather MH, Sulaiman MN et al (2015) “Looks can be deceiving”: adrenal teratoma causing diagnostic difficulty. Case Rep Urol 2015:232591. doi:10.1155/2015/232591
131.
go back to reference Dehner LP (1973) Intrarenal teratoma occurring in infancy: report of a case with discussion of extragonodal germ cell tumors in infancy. J Pediatr Surg 8:369–378PubMedCrossRef Dehner LP (1973) Intrarenal teratoma occurring in infancy: report of a case with discussion of extragonodal germ cell tumors in infancy. J Pediatr Surg 8:369–378PubMedCrossRef
132.
go back to reference Mochizuki K, Ohno Y, Tokai Y et al (2006) Congenital intrarenal teratoma arising from a horseshoe kidney. J Pediatr Surg 41:1313–1315PubMedCrossRef Mochizuki K, Ohno Y, Tokai Y et al (2006) Congenital intrarenal teratoma arising from a horseshoe kidney. J Pediatr Surg 41:1313–1315PubMedCrossRef
133.
go back to reference al-Baghdadi R (1992) Fetus in fetu in the liver: case report and review of the literature. J Pediatr Surg 27:1491–1492PubMedCrossRef al-Baghdadi R (1992) Fetus in fetu in the liver: case report and review of the literature. J Pediatr Surg 27:1491–1492PubMedCrossRef
134.
go back to reference Magnus KG, Millar AJ, Sinclair-Smith CC et al (1999) Intrahepatic fetus-in-fetu: a case report and review of the literature. J Pediatr Surg 34:1861–1864PubMedCrossRef Magnus KG, Millar AJ, Sinclair-Smith CC et al (1999) Intrahepatic fetus-in-fetu: a case report and review of the literature. J Pediatr Surg 34:1861–1864PubMedCrossRef
135.
go back to reference Park WH, Choi SO, Kim JI (2002) Congenital gastric teratoma with gastric perforation mimicking meconium peritonitis. J Pediatr Surg 37:E11 Park WH, Choi SO, Kim JI (2002) Congenital gastric teratoma with gastric perforation mimicking meconium peritonitis. J Pediatr Surg 37:E11
138.
go back to reference Gupta DK, Srinivas M, Dave S et al (2000) Gastric teratoma in children. Pediatr Surg Int 16:329–332PubMedCrossRef Gupta DK, Srinivas M, Dave S et al (2000) Gastric teratoma in children. Pediatr Surg Int 16:329–332PubMedCrossRef
139.
go back to reference Utsch B, Fleischhack G, Knöpfle G et al (2001) Immature gastric teratoma of the lesser curvature in a male infant. J Pediatr Gastroenterol Nutr 32:204–206PubMedCrossRef Utsch B, Fleischhack G, Knöpfle G et al (2001) Immature gastric teratoma of the lesser curvature in a male infant. J Pediatr Gastroenterol Nutr 32:204–206PubMedCrossRef
140.
go back to reference Gamanagatti S, Kandpal H (2007) Gastric teratoma. Singapore Med J 48:e99–e101PubMed Gamanagatti S, Kandpal H (2007) Gastric teratoma. Singapore Med J 48:e99–e101PubMed
142.
go back to reference Kreczy A, Alge A, Menardi G et al (1994) Teratoma of the umbilical cord. Case report with review of the literature. Arch Pathol Lab Med 118:934–937PubMed Kreczy A, Alge A, Menardi G et al (1994) Teratoma of the umbilical cord. Case report with review of the literature. Arch Pathol Lab Med 118:934–937PubMed
143.
go back to reference Satgé DC, Laumond MA, Desfarges F et al (2001) An umbilical cord teratoma in a 17-week-old fetus. Prenat Diagn 21:284–288PubMedCrossRef Satgé DC, Laumond MA, Desfarges F et al (2001) An umbilical cord teratoma in a 17-week-old fetus. Prenat Diagn 21:284–288PubMedCrossRef
146.
go back to reference Wang L, Du X, Li M (1995) Placental teratoma. A case report and review of the literature. Pathol Res Pract 191:1267–1270PubMedCrossRef Wang L, Du X, Li M (1995) Placental teratoma. A case report and review of the literature. Pathol Res Pract 191:1267–1270PubMedCrossRef
147.
go back to reference Ahmed N, Kale V, Thakkar H et al (2004) Sonographic diagnosis of placental teratoma. J Clin Ultrasound 32:98–101PubMedCrossRef Ahmed N, Kale V, Thakkar H et al (2004) Sonographic diagnosis of placental teratoma. J Clin Ultrasound 32:98–101PubMedCrossRef
Metadata
Title
Management of fetal teratomas
Authors
Jose L. Peiró
Lourenço Sbragia
Federico Scorletti
Foong Y. Lim
Aimen Shaaban
Publication date
01-07-2016
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Surgery International / Issue 7/2016
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI
https://doi.org/10.1007/s00383-016-3892-3

Other articles of this Issue 7/2016

Pediatric Surgery International 7/2016 Go to the issue