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Pediatric Surgery International

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01-03-2009 | Original Article

Long-term outcomes of surgery for malignant sacrococcygeal teratoma: 20-year experience of a regional UK centre

Authors: Basem A. Khalil, Asher Aziz, Pierina Kapur, Gill Humphrey, Antonino Morabito, James Bruce

Published in: Pediatric Surgery International | Issue 3/2009

Abstract

Background

The timing of surgery for malignant sacrococcygeal teratoma is controversial. The long-term outcomes and complications of surgery for this rare tumour are presented.

Methods

All cases of malignant sacrococcygeal teratoma in the 20-year period 1987–2006 were identified and the case notes retrieved. The age at diagnosis, investigations, presentation, type of surgery, early complications, recurrence rates, long-term complications and outcomes were recorded.

Results

Twelve patients (three males, nine females) were identified. Mean age at presentation was 20.8 months (range: 12–39 months). All had the Carboplatin–Etoposide–Bleomycin chemotherapeutic protocol. The average time of follow-up was 10.6 years (range: 1–17 years). Ten patients had excision of their tumours following chemotherapy, whilst two patients had excision prior to chemotherapy. Two patients had recurrence of their tumours. There was one death (8%), which was due to disseminated metastasis. The other 11 children were all well at the last follow-up.

Conclusion

Surgery for malignant sacrococcygeal teratoma is safe and has a low complication rate. The long-term outcomes are favourable with minimal side effects.

Werb P, Scurry J, Ostor A et al (1992) Survey of congenital tumours in perinatal necropsies. Pathology 24:247–253. doi:10.3109/00313029209068876 PubMedCrossRef

Isaacs H (1997) Germ cell tumours. In: Isaac H (ed) Tumours of the fetus and newborn. Saunders, Philadelphia, pp 15–38

Raney RB Jr, Chatten J, Littman P et al (1981) Treatment strategies for infants with malignant sacrococcygeal teratoma. J Pediatr Surg 16(4) suppl 1:573–577PubMedCrossRef

Billmire DF (2006) Malignant germ cell tumors in childhood. Semin Pediatr Surg 15(1):30–36PubMedCrossRef

Gobel U, Schneider DT, Calaminus G et al (2001) Multimodal treatment of malignant sacrococcygeal germ cell tumors: a prospective analysis of 66 patients of the German cooperative protocols MAKEI 83/86 and 89. J Clin Oncol 19(7):1943–1950PubMed

Calaminus G, Schneider DT, Bokkerink JP et al (2003) Prognostic value of tumor size, metastasis, extension into bone and increased tumour marker in children with malignant sacrococcygeal germ cell tumours: a prospective evaluation of 71 patients treated in the German cooperative protocols Maligne Keimzelltumoren (MAKEI) 83/86 and MAKEI 89. J Clin Oncol 21(5):781–786PubMedCrossRef

Howman-Giles R, Holland AJ, Mihm D et al (2008) Somatic malignant transformation in a sacrococcygeal teratoma in a child, the use of F(18)FDG PET imaging. Pediatr Surg Int 24(4):475–478PubMedCrossRef

Huddart SN, Mann JR, Robinson K et al (2003) Children’s Cancer Study Group sacrococcygeal teratoma: the UK Children’s Cancer Study Group’s experience. I. Neonatal. Pediatr Surg Int 19(1–2):47–51PubMed

Gabra HO, Jesudason EC, McDowell HP et al (2006) Sacrococcygeal teratoma: a 25-year experience in a UK regional centre. J Pediatr Surg 41(9):1513–1516PubMedCrossRef

10.

Derikx JP, De Backer A, van de Schoot L et al (2006) Factors associated with recurrence and metastasis in sacrococcygeal teratoma. Br J Surg 93(12):1543–1548PubMedCrossRef

11.

De Backer A, Madern GC, Hakvoort-Cammel FG et al (2006) Study of the factors associated with recurrence in children with sacrococcygeal teratoma. J Pediatr Surg 41(1):173–181 discussion 173–81PubMedCrossRef

12.

Schneider DT, Wessalowski R, Calaminus G et al (2001) Treatment of recurrent malignant sacrococcygeal germ cell tumors: analysis of 22 patients registered in the German protocols MAKEI 83/86, 89, and 96. J Clin Oncol 19(7):1951–1960PubMed

13.

Misra D, Pritchard J, Drake DP et al (1997) Markedly improved survival in malignant sacro-coccygeal teratomas: 16 years experience. Eur J Pediatr Surg 7(3):152–155PubMedCrossRef

14.

Mann JR, Gray ES, Thornton C et al (2008) Mature and immature extracranial teratomas in children: the UK Children’s Cancer Study group experience. J Clin Oncol 26(21):3590–3597. doi:10.1200/JCO.2008.16.0622 PubMedCrossRef

15.

Schmidt B, Haberlik A, Uray E et al (1999) Sacrococcygeal teratoma: clinical course and prognosis with a special view to long-term functional results. Pediatr Surg Int 15(8):573–576. doi:10.1007/s003830050675 PubMedCrossRef

Title: Long-term outcomes of surgery for malignant sacrococcygeal teratoma: 20-year experience of a regional UK centre
Authors: Basem A. Khalil
Asher Aziz
Pierina Kapur
Gill Humphrey
Antonino Morabito
James Bruce
Publication date: 01-03-2009
Publisher: Springer-Verlag
Published in: Pediatric Surgery International / Issue 3/2009
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-009-2329-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Long-term outcomes of surgery for malignant sacrococcygeal teratoma: 20-year experience of a regional UK centre

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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