Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Pediatric Surgery International
Published in: Pediatric Surgery International 9/2009

01-09-2009 | Original Article

Neck nodule and thyroid cancer in young without radiation exposure history

Published in: Pediatric Surgery International | Issue 9/2009

Login to get access

Abstract

Purpose

The aim of this study was to analyze the results of histopathological studies in neck masses observed in young patients. The neck masses were detected using ultrasonography and fine-needle aspiration cytology (FNAC).

Methods

In this retrospective study, we analyzed 234 young patients who were surgically treated for neck masses at Chang Gung Medical Center in Linkou. The mean age of the 234 young patients was 16.3 ± 4.0 years (range 1–20 years). Neck ultrasonography studies were conducted using a real-time ultrasonographic machine and a 10 MHz transducer. FNAC was performed for the suspected neck nodules.

Results

Of the 234 cases, 187 (79.9%) were surgically confirmed to be benign lesions, including four cases that were diagnosed as atypical adenoma. Malignant thyroid masses were identified in 47 patients. Surgery confirmed 22 cases to be lesions that were non-thyroid in origin, including those developing from a cyst, soft tissue, and with a lymphatic origin. Diagnostic accuracies of the FNAC and frozen section examination were found to be 91.1 and 97.7%, respectively.

Conclusions

In the study population, 20.1% of the neck masses were malignant. Except in cases of follicular thyroid neoplasm, neck ultrasonography with FNAC could effectively identify the thyroid or non-thyroid origin of these masses with high-diagnostic accuracy.
Literature
1.
Amrikachi M, Ponder TB, Wheeler TM, Smith D, Ramzy I (2005) Thyroid fine-needle aspiration biopsy in children and adolescents: experience with 218 aspirates. Diagn Cytopathol 32:189–192PubMedCrossRef
2.
Daneshbod Y, Banani A, Kumar PV (2006) Aberrant thymus and parathyroid gland presenting as a recurrent lateral neck mass: a case report. Ear Nose Throat J 85:452–453PubMed
3.
Brignardello E, Corrias A, Isolato G et al (2008) Ultrasound screening for thyroid carcinoma in childhood cancer survivors: a case series. J Clin Endocrinol Metab 93:4840–4843PubMedCrossRef
4.
O’Kane P, Shelkovoy E, McConnell RJ et al (2008) Differences in sonographic conspicuity according to papillary thyroid cancer subtype: results of the Ukrainian–American cohort study after the Chornobyl accident. AJR Am J Roentgenol 191:W293–W298PubMedCrossRef
5.
Kuo SF, Chao TC, Chang HY et al (2009) The role of radioactive iodine therapy in young patients with papillary thyroid cancer. Clin Nucl Med 34:4–6PubMedCrossRef
6.
Popovtzer A, Shpitzer T, Bahar G, Feinmesser R, Segal K (2006) Thyroid cancer in children: management and outcome experience of a referral center. Otolaryngol Head Neck Surg 135:581–584PubMedCrossRef
7.
Schlumberger M, De Vathaire F, Travagli JP et al (1987) Differentiated thyroid carcinoma in childhood: long term follow-up of 72 patients. J Clin Endocrinol Metab 65:1088–1094PubMedCrossRef
8.
Lin JD, Huang BY, Weng HF et al (1997) Thyroid ultrasonography with the fine needle aspiration cytology for the diagnosis of thyroid cancer. J Clin Ultrasound 25:111–118PubMedCrossRef
9.
Magnanti BL, Tevfik Dorak M, et al (2009) Geographical analysis of thyroid cancer in young people from northern England: evidence for a sustained excess in females in Cumbria. Eur J Cancer [Epub ahead of print]
10.
Kim DW, Lee EJ, Kim SH et al (2009) Ultrasound-guided fine-needle aspiration biopsy of thyroid nodules: comparison in efficacy according to nodule size. Thyroid 19:27–31PubMedCrossRef
11.
Porterfield JR Jr, Grant CS, Dean DS et al (2008) Reliability of benign fine needle aspiration cytology of large thyroid nodules. Surgery 144:963–968PubMedCrossRef
12.
Inskip PD (2001) Thyroid cancer after radiotherapy for childhood cancer. Med Pediatr Oncol 36:568–573PubMedCrossRef
13.
Elisei R, Romei C, Vorontsova T et al (2001) RET/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults. J Clin Endocrinol Metab 86:3211–3216PubMedCrossRef
14.
Nishiyama RH, Schmidt RW, Batsakis JG (1962) Carcinoma of thyroid gland in children and adolescents. J Am Med Assoc 181:1034–1038
15.
Hrafnkelsson J, Jonasson JG, Sigurdsson G et al (1988) Thyroid cancer in Iceland 1955–1984. Acta Endocrinol 118:566–572PubMed
16.
Tallroth E, Bäckdahl M, Einhorn J et al (1986) Thyroid carcinoma in children and adolescents. Cancer 58:2329–2332PubMedCrossRef
17.
Quimby EH, Werner SC (1949) Late radiation effects in roentgen therapy for hyperthyroidism. J Am Med Assoc 140:1046–1047
18.
Samuel AM, Sharma SM (1991) Differentiated thyroid carcinomas in children and adolescents. Cancer 67:2186–2190PubMedCrossRef
19.
Belge G, Thode B, Bartnitzke S, Bullerdiek J (1994) Cytogenetic biclonality corresponding to multiphasic differentiation in an atypical thyroid adenoma. Cancer Genet Cytogenet 78:102–104PubMedCrossRef
20.
Sarquis MS, Weber F, Shen L et al (2006) High frequency of loss of heterozygosity in imprinted, compared with nonimprinted, genomic regions in follicular thyroid carcinomas and atypical adenomas. J Clin Endocrinol Metab 91:262–269PubMedCrossRef
21.
Tzen CY, Huang YW, Fu YS (2003) Is atypical follicular adenoma of the thyroid a preinvasive malignancy? Hum Pathol 34:666–669PubMedCrossRef
22.
Chennupati SK, Schipor I, Mirza N (2006) Microdebrider decompression of schwannoma: a novel method of excising a neck mass. Laryngoscope 116:2086–2088PubMedCrossRef
23.
Al-Shaikhi A, Kay S, Laberge JM (2003) External jugular venous aneurysm: an unusual cause of neck mass in a young child. J Pediatr Surg 38:1557–1559PubMedCrossRef
24.
Kim HS, Lee HK, Weon YC, Kim HJ (2005) Alveolar soft-part sarcoma of the head and neck: clinical and imaging features in five cases. Am J Neuroradiol 26:1331–1335PubMed
25.
Wang J, Heffner DK, Venegas R, French SW (1999) Atypical chondroma of the cricoid cartilage: fine needle aspiration cytology and histopathologic findings. Diagn Cytopathol 20:164–166PubMedCrossRef
Metadata
Title
Neck nodule and thyroid cancer in young without radiation exposure history
Publication date
01-09-2009
Published in
Pediatric Surgery International / Issue 9/2009
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI
https://doi.org/10.1007/s00383-009-2416-9

Other articles of this Issue 9/2009

Pediatric Surgery International 9/2009 Go to the issue

Original Article

Conjoined twins in the Philippines: experience of a single institution

Case Report

Anorectal malformation associated with a perineal protrusion of the rectal mucosa: case presentation

Original Article

Surgical complications after living donor liver transplantation in patients with biliary atresia: a relatively high incidence of portal vein complications

Case Report

Thymopharyngeal duct cyst: an unusual cause of respiratory compromise

Original Article

Prognostic factors in jejuno-ileal atresia

Case Report

Congenital diaphragmatic hernia with a pure duplication of chromosome 1q: report of the first surviving case