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01-09-2009 | Original Article

Surgical complications after living donor liver transplantation in patients with biliary atresia: a relatively high incidence of portal vein complications

Authors: Yukiko Takahashi, Yuko Nishimoto, Toshiharu Matsuura, Makoto Hayashida, Tatsuro Tajiri, Yuji Soejima, Akinobu Taketomi, Yoshihiko Maehara, Tomoaki Taguchi

Published in: Pediatric Surgery International | Issue 9/2009

Abstract

Background/purpose

The aim of this study is to present the surgical complications in living donor liver transplantation (LDLT) for biliary atresia (BA) as a treatment for end stage liver disease.

Patients and methods

Twenty-nine LDLTs were performed in patients with BA between October 1996 and April 2008 in Department of Pediatric Surgery at Kyushu University Hospital. The initial immunosuppression was a combination of tacrolimus and steroids.

Results

Twenty-eight of 29 cases with BA, who previously underwent Kasai’s operation and LDLT was performed at a median age of 9.1 years (range 7 months to 28 years). Only one case was performed primary LDLT. Post-transplant complications included portal vein complications (n = 5), three of which successfully treated by Rex-shunt or ballooning. Others were bile leakage (n = 4), intestinal perforation (n = 4), and so on. The overall survival rate was 86.2% (25/29). One patient died of chronic rejection, surgical complications after LDLT in BA while others died of sepsis, multi-organ failure, and brain hemorrhage.

Conclusion

The incidence of portal vein complications and intestinal perforations was relatively high in LDLT for BA, possibly due to inflammation of the hepatoduodenal ligament and colonic adhesion to the liver. It is important to make an accurate diagnosis at an early stage and provide appropriate treatment.

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Title: Surgical complications after living donor liver transplantation in patients with biliary atresia: a relatively high incidence of portal vein complications
Authors: Yukiko Takahashi
Yuko Nishimoto
Toshiharu Matsuura
Makoto Hayashida
Tatsuro Tajiri
Yuji Soejima
Akinobu Taketomi
Yoshihiko Maehara
Tomoaki Taguchi
Publication date: 01-09-2009
Publisher: Springer-Verlag
Published in: Pediatric Surgery International / Issue 9/2009
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-009-2430-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Surgical complications after living donor liver transplantation in patients with biliary atresia: a relatively high incidence of portal vein complications

Abstract

Background/purpose

Patients and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background/purpose

Patients and methods

Results

Conclusion

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