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Child's Nervous System
Published in: Child's Nervous System 9/2018

01-09-2018 | Case Report

Rapidly progressive fatal idiopathic hypertrophic pachymeningitis with brainstem involvement in a child

Authors: Kosuke Tsuchida, Shinobu Fukumura, Akiyo Yamamoto, Yukinori Akiyama, Hiroshi Hirano, Hiroyuki Tsutsumi

Published in: Child's Nervous System | Issue 9/2018

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Abstract

Background

Hypertrophic pachymeningitis (HP) is a rare disorder characterized by diffuse thickening of the dura mater with resultant neurologic deficits. HP develops secondary to various conditions or idiopathically usually in adults but rarely in children.

Case report

We describe a 3-year-old female child with idiopathic HP. Her HP involved the entire central nervous system with progression into the brainstem. The lesion responded poorly to pulsed steroids or any immunosuppressants. The brainstem lesion grew rapidly and formed various nodules that ultimately resulted in brain death. This is the first fatal case of HP in a child.
Literature
1.
2.
Kupersmith MJ, Martin V, Heller G, Shah A, Mitnick HJ (2004) Idiopathic hypertrophic pachymeningitis. Neurology 62:686–694CrossRefPubMed
3.
Yonekawa T, Murai H, Utsuki S, Matsushita T, Masaki K, Isobe N, Yamasaki R, Yoshida M, Kusunoki S, Sakata K, Fujii K, Kira JI (2014) A nationwide survey of hypertrophic pachymeningitis in Japan. J Neurol Neurosurg Psychiatry 85:732–739CrossRefPubMed
4.
Dziedzic T, Wojciechowski J, Nowak A, Marchel A (2015) Hypertrophic pachymeningitis. Childs Nerv Syst 31:1025–1031CrossRefPubMed
5.
Sharma PK, Saikia B, Sharma R, Gagneja V, Khilnani P (2014) Pachymeningitis in a young child responded to antitubercular therapy: a case report. J Child Neurol 29:92–95CrossRef
6.
Karimi A, Tabatabaei SR, Shiva F, Sayfikar M, Jafari M, Shirvani F, Shiari R (2014) Tuberculous pachymeningitis in a young child with spinal involvement: a case report. Int J Infect Dis 21:419CrossRef
7.
Asano T, Hayashida M, Ogawa K, Adachi K, Teramoto A, Yamamoto M (1998) Hypertrophic cranial pachymeningitis in a patient with aplastic anemia. Ann Hematol 77:279–282CrossRefPubMed
8.
van Toorn R, Esser M, Smit D, Andronikou S (2008) Idiopathic hypertrophic cranial pachymeningitis causing progressive polyneuropathies in a child. Eur J Paediatr Neurol Off J Eur Paediatr Neurol Soc 12:144–147CrossRef
9.
Aburahma SK, Anabtawi AG, Al Rimawi HS, Elheis MA, Mohtaseb AH (2009) Idiopathic hypertrophic pachymeningitis in a child with hydrocephalus. Pediatr Neurol 40:457–460CrossRefPubMed
10.
Rojana-udomsart A, Pulkes T, Viranuwatti K, Laothamatas J, Phudhichareonrat S, Witoonpanich R (2008) Idiopathic hypertrophic cranial pachymeningitis. J Clin Neurosci 15:465–469CrossRefPubMed
11.
Van Toorn R, Esser M, Smit D, Andronikou S (2008) Idiopathic hypertrophic cranial pachymeningitis causing progressive polyneuropathies in a child. Eur J Paediatr Neurol 12:144–147CrossRefPubMed
12.
Lee YC, Chueng YC, Hsu SW, Lui CC (2003) Idiopathic hypertrophic cranial pachymeningitis: case report with 7 years of imaging follow-up. AJNR Am J Neuroradiol 24:119–123PubMed
13.
Kleiter I, Hans VH, Schuierer G, Marienhagen J, Hau P, Schütz H, Bogdahn U, Steinbrecher A (2004) Intraventricular cytarabine in a case of idiopathic hypertrophic pachymeningitis. J Neurol Neurosurg Psychiatry 75:1346–1348CrossRefPubMedPubMedCentral
14.
Sable SG, Ramadan NM (1991) Meningeal enhancement and low CSF pressure headache. An MRI study. Cephalalgia 11(6):275–276CrossRefPubMed
Metadata
Title
Rapidly progressive fatal idiopathic hypertrophic pachymeningitis with brainstem involvement in a child
Authors
Kosuke Tsuchida
Shinobu Fukumura
Akiyo Yamamoto
Yukinori Akiyama
Hiroshi Hirano
Hiroyuki Tsutsumi
Publication date
01-09-2018
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 9/2018
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-018-3819-5

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