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01-08-2018 | Original Paper

Sleep disorders in children with brain tumors: a pilot study based on a sleep disorder questionnaire

Authors: Chiara Pilotto, Eva Passone, Elisa Coassin, Silvia Birri, Ettore Bidoli, Giovanni Crichiutti, Paola Cogo, Maurizio Mascarin

Published in: Child's Nervous System | Issue 8/2018

Abstract

Purpose

The aim of this study is to compare the prevalence of sleep disorders (SD) between children treated for brain tumors and healthy children, and to define the type of SD.

Methods

A case-control study was performed from October 2014 to April 2015. Inclusion criteria were patients between 2 and 16 years with “cases” defined as children affected by central nervous system tumors at least 3 months after the end of treatment (surgery and/or radiotherapy and/or chemotherapy) at the time of evaluation and “controls” as healthy children. Children’s sleep quality was assessed with a questionnaire administered to parents (Child’s Sleep Habits Questionnaire, CSHQ). A total score greater than 41 is suggestive for the presence of disturbed sleep. The risk of SD was estimated by the odds ratio (OR) and their 95% confidence intervals (95% CI) through logistic regression models.

Results

Twenty-nine cases and 87 controls (in a 1:3 model) were enrolled, for a total of 116 subjects. The prevalence of SD resulted of 82.8% among cases and 64.4% in controls. A statistically significant difference between the two groups (OR 2.65; 95% CI 0.92–7.65) was not reached. Analyzing singular disturbances, parasomnias and night awakenings showed a statistically significant difference between the two groups (OR 4.32; 95% CI 1.08–17.34).

Conclusions

Our study revealed a trend toward SD in children with brain tumor when compared to healthy population. Hovewer, analyzing specific subtypes of SD some significant differences were obtained. A significant difference was obtained only for specific subtypes of SD. Further investigations could better define the real burden of SD.

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Title: Sleep disorders in children with brain tumors: a pilot study based on a sleep disorder questionnaire
Authors: Chiara Pilotto
Eva Passone
Elisa Coassin
Silvia Birri
Ettore Bidoli
Giovanni Crichiutti
Paola Cogo
Maurizio Mascarin
Publication date: 01-08-2018
Publisher: Springer Berlin Heidelberg
Published in: Child's Nervous System / Issue 8/2018
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-018-3809-7

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Sleep disorders in children with brain tumors: a pilot study based on a sleep disorder questionnaire

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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