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Child's Nervous System
Published in: Child's Nervous System 6/2019

01-06-2019 | Strabismus | Case Report

Medulloepithelioma with heterologous osteoid component: a case report and review of literature

Authors: Yanal Omari, Ahmad A. Karkash, Razan A. Mansour, Nisreen Amayiri, Maisa Swaidan, Maysa Al-Hussaini

Published in: Child's Nervous System | Issue 6/2019

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Abstract

Purpose

Medulloepithelioma is a rare brain tumor that has been classified as embryonal tumor with multilayered rosettes (ETMR) if it harbors C19MC amplification. In rare instances, it shows evidence of heterologous differentiation.

Methods

We report a case of a 10-year-old female who presented with headache, squint, and minimal left sided weakness of 1 week duration.

Results

Microscopy revealed a small round blue cell tumor with focal glandular and tubular differentiation. In one focus, well-developed osteoid was identified. The tumor labeled with LIN28A immunostain.

Conclusions

Unusual features can be encountered in medulloepithelioma which should be in the differential diagnosis of CNS embryonal tumors. Full description of the case with review of the literature and comparison between cases with and without heterologous elements is presented.
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Metadata
Title
Medulloepithelioma with heterologous osteoid component: a case report and review of literature
Authors
Yanal Omari
Ahmad A. Karkash
Razan A. Mansour
Nisreen Amayiri
Maisa Swaidan
Maysa Al-Hussaini
Publication date
01-06-2019
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 6/2019
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-018-04041-8

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