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Child's Nervous System
Published in: Child's Nervous System 3/2017

01-03-2017 | Original Paper

Clinicopathological features and microsurgical outcomes for giant pediatric intracranial tumor in 60 consecutive cases

Authors: Ailing Guo, Vigneyshwar Suresh, Xianzhi Liu, Fuyou Guo

Published in: Child's Nervous System | Issue 3/2017

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Abstract

Purpose

Giant pediatric intracranial tumor (GPIT) remains to be a challenging disease with high morbidity and mortality.

Methods

The clinical data of 60 patients under 18 years of age operated on with GPIT (≥5 cm in diameter) were retrospectively analyzed.

Results

Gross total resection was achieved in 46 cases (77%) and subtotal resection was obtained in 14 cases (23%). Ninety percent (47/52) of the cases with obstructive hydrocephalus were resolved remarkably and only 10% (5/52) of the patients needed a ventriculoperitoneal shunt after tumor resection. Postoperative histopathological type revealed malignant brain tumors in 51 cases (85%). The most common neoplasm was medulloblastoma; other types include the following: ependymoma, pilocytic astrocytoma, mixed glioma, primitive neuroectoderm tumor (PNET), subependymal giant cell astrocytoma, gangliocytoma, gliosarcoma, choroid plexus carcinoma, and atypical teratoid rhabdoid tumor (AT/RT). Benign histopathological categories include the following: craniopharyngioma, choroid plexus papilloma, and meningioma. No death or serious complications occurred after the operation. However, transient subcutaneous effusion occurred in 14 patients postoperatively, nerve injury including the posterior cranial nerve in two cases and abduction nerve in one case, and mutism and pulmonary infection were observed in two cases, respectively. The follow-up period ranged from 1 to 72 months, with an average of 32 months. Poor prognosis occurred significantly in the high-grade malignant tumors and PNET, AT/RT, and gliosarcoma were implicated in the death of patients within 1 year.

Conclusions

To the best of our knowledge, the present study is the first description of clinicopathological features and the largest case analysis for GPIT. Optimal outcomes for GPIT were achieved by strict evaluation and perioperative management as well as microsurgical skills.
Literature
1.
Devorah Segal, Matthias A. Karajannis. (2016) Pediatric brain tumors: an update. Current Problems in Pediatric and Adolescent Health Care 46 (7):242–250,
2.
Neervoort FW, Van Ouwerkerk WJ, Folkersma H et al (2010) Surgical morbidity and mortality of pediatric brain tumors: a single center audit. Childs Nerv Syst 26(11):1583–1592CrossRefPubMedPubMedCentral
3.
Valencia-Moya A, González-García L, Ros-López B et al (2016) Prognosis of atypical teratoid rhabdoid tumors (AT/RT) treated with multimodal therapy protocols. Report of our series. Neurocirugia (Astur) 27(2):87–94CrossRef
4.
de Oliveira RS, Deriggi DJ, Furlanetti LL et al (2015) The impact of surgical resection of giant supratentorial brain tumor in pediatric patients: safety and neurological outcome evaluated in 23 consecutive cases. Childs Nerv Syst 31(1):67–75CrossRefPubMed
5.
Nair BR, Joseph V, Chacko G et al (2014) Giant solid hemangioblastoma of the cerebellopontine angle: a technically challenging case. Neurol India 62(2):228–229CrossRefPubMed
6.
Salunke P, Futane S (2013) Trans-sylvian transtentorial approach for a giant craniopharyngioma of the posterior fossa. Acta Neurochir 155(6):1041–1043CrossRefPubMed
7.
Satyarthee GD, Mahapatra AK (2015) Giant pediatric glioblastoma multiforme causing primary calvarial erosion and sutural diastasis presenting with enlarged head. J Pediatr Neurosci 10(3):290–293CrossRefPubMedPubMedCentral
8.
Hankinson TC, Dudley RW, Torok MR et al (2016) Short-term mortality following surgical procedures for the diagnosis of pediatric brain tumors: outcome analysis in 5533 children from SEER, 2004–2011. J Neurosurg Pediatr 17(3):289–297CrossRefPubMed
9.
Cartmill M, Hewitt M, Walker D et al (2001) The use of chemotherapy to facilitate surgical resection in pleomorphic xanthoastrocytoma: experience in a single case. Childs Nerv Syst 17(9):563–566CrossRefPubMed
10.
Mathews M, Newman R, Chappell ET (2006) Management of coagulopathy in the setting of acute neurosurgical disease and injury. Neurocrit Care 5(2):141–152CrossRefPubMed
11.
Guo F, Wang J, Song L et al (2013) Clinical features and surgical management of four peculiar cases of intracranial metastases from renal cell carcinoma. Neurol Sci 34(2):149–156CrossRefPubMed
12.
Wang HH, Luo CB, Guo WY et al (2016) Preoperative embolization of hypervascular pediatric brain tumors: evaluation of technical safety and outcome. Childs Nerv Syst 29(11):2043–2049CrossRef
13.
O’Lynnger TM, Shannon CN, Le TM et al (2016) Standardizing ICU management of pediatric traumatic brain injury is associated with improved outcomes at discharge. J Neurosurg Pediatr 17(1):19–26CrossRefPubMed
14.
Asirvatham JR, Deepti AN, Chyne R et al (2011) Pediatric tumors of the central nervous system: a retrospective study of 1,043 cases from a tertiary care center in South India. Childs Nerv Syst 27(8):1257–1263CrossRefPubMed
15.
Santos MM, Faria CC, Miguéns J (2016) Pediatric central nervous system tumors: review of a single Portuguese institution. Childs Nerv Syst 32(7):1227–1236CrossRefPubMed
16.
Wang C, Yuan XJ, Jiang MW et al (2016) Clinical characteristics and abandonment and outcome of treatment in 67 Chinese children with medulloblastoma. J Neurosurg Pediatr 17(1):49–56CrossRefPubMed
17.
Adeberg S, Bernhardt D, Harrabi SB et al (2016) Radiotherapy plus concomitant temozolomide in primary gliosarcoma. J Neuro-Oncol 128(2):341–348CrossRef
18.
von Lehe M, Kim HJ, Schramm J et al (2013) A comprehensive analysis of early outcomes and complication rates after 769 craniotomies in pediatric patients. Childs Nerv Syst 29(5):781–790CrossRef
Metadata
Title
Clinicopathological features and microsurgical outcomes for giant pediatric intracranial tumor in 60 consecutive cases
Authors
Ailing Guo
Vigneyshwar Suresh
Xianzhi Liu
Fuyou Guo
Publication date
01-03-2017
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 3/2017
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-017-3341-1

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