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01-06-2016 | Case Report

Long-term survival of an infant with an atypical teratoid/rhabdoid tumor following subtotal resection and low-cumulative dose chemotherapy: a case report

Authors: Viktor Arnhold, Florian Oyen, Reinhard Schneppenheim, Hannes Haberl, Arend Koch, Michael C. Frühwald, Pablo Hernáiz Driever

Published in: Child's Nervous System | Issue 6/2016

Abstract

Introduction

Atypical teratoid/rhabdoid tumor (AT/RT) is an aggressive embryonal tumor of the central nervous system with a generally dismal prognosis, especially in patients younger than 12 months.

Discussion

We here describe the unusual case of an infant with AT/RT with long-term survival despite low-cumulative dose chemotherapy after subtotal resection. Due to a poor neurological situation and an unfavorable oncological prognosis, therapy was halted after two partial surgical resections and four of the nine chemotherapy courses recommended by the European Rhabdoid Registry, without the patient receiving either radiotherapy or high-dose chemotherapy. The patient is alive without evidence of disease 52 months after diagnosis.

Conclusion

This case report highlights that independent prognostic factors are urgently needed for optimizing treatment stratification and preventing overtreatment.

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Title: Long-term survival of an infant with an atypical teratoid/rhabdoid tumor following subtotal resection and low-cumulative dose chemotherapy: a case report
Authors: Viktor Arnhold
Florian Oyen
Reinhard Schneppenheim
Hannes Haberl
Arend Koch
Michael C. Frühwald
Pablo Hernáiz Driever
Publication date: 01-06-2016
Publisher: Springer Berlin Heidelberg
Published in: Child's Nervous System / Issue 6/2016
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-015-2999-5

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Springer Medicine

Long-term survival of an infant with an atypical teratoid/rhabdoid tumor following subtotal resection and low-cumulative dose chemotherapy: a case report

Abstract

Introduction

Discussion

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Introduction

Discussion

Conclusion

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