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01-11-2013 | Original Paper

Type II focal cortical dysplasia: electroclinical study and surgical outcome in 31 pediatric patients

Authors: Daniel Noli, Marcelo Bartuluchi, Federico Sanchez González, María Carolina Kaltenmeier, Ricardo Cersosimo, Carlos Rugilo, Juan P. Princich, Fabiana Lubieniecki, Hugo Pomata, Roberto Caraballo

Published in: Child's Nervous System | Issue 11/2013

Abstract

Objective

The aim of this study was to analyze the electroclinical features and surgical outcome of 31 pediatric patients with focal cortical dysplasia (FCD) type II.

Material and methods

We conducted a retrospective, descriptive study of 31 patients with FCD type II followed between 1998 and 2011. We included patients with FCD type II confirmed by histopathological examination with abnormal magnetic resonance imaging and at least 1 year of follow-up.

Results

All patients had severe focal epilepsy; in infancy, four of them had also had epileptic spasms, associated with hypsarrhythmia in three. Focal status epilepticus occurred in five patients (16 %) and epilepsia partialis continua in one (3.2 %). Seizures occurred during sleep in 20 (64.5 %) and in clusters in 19 (61.3 %) patients. Neurological examination showed a mild motor deficit in seven (22.8 %) patients. Interictal abnormalities were characterized by rhythmic spikes and polyspike discharges, increasing during sleep in 13 (41.9 %) patients. Average time of follow-up after surgery was 4.7 years with a median time of 4 years and a range from 1 to 9 years. Engel classification class I was found in 20 (67.7 %) and class II in 3 cases (9.6 %). There were no significant changes after an average time of follow-up of 4.7 years.

Conclusion

Our results confirm that surgery is the best treatment option for pediatric patients with refractory focal epilepsy due to type II FCD. A statistically significant correlation was found between a good prognosis and age at epilepsy onset older than 2 years.

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Title: Type II focal cortical dysplasia: electroclinical study and surgical outcome in 31 pediatric patients
Authors: Daniel Noli
Marcelo Bartuluchi
Federico Sanchez González
María Carolina Kaltenmeier
Ricardo Cersosimo
Carlos Rugilo
Juan P. Princich
Fabiana Lubieniecki
Hugo Pomata
Roberto Caraballo
Publication date: 01-11-2013
Publisher: Springer Berlin Heidelberg
Published in: Child's Nervous System / Issue 11/2013
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-013-2165-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Type II focal cortical dysplasia: electroclinical study and surgical outcome in 31 pediatric patients

Abstract

Objective

Material and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Material and methods

Results

Conclusion

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