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Child's Nervous System
Published in: Child's Nervous System 11/2013

01-11-2013 | Original Paper

The use of MRI-guided laser-induced thermal ablation for epilepsy

Authors: Zulma Tovar-Spinoza, David Carter, David Ferrone, Yaman Eksioglu, Sean Huckins

Published in: Child's Nervous System | Issue 11/2013

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Abstract

Purpose

Epilepsy surgery is constantly researching for new options for patients with refractory epilepsy. MRI-guided laser-induced thermal ablation for epilepsy is an exciting new minimally invasive technology with an emerging use for lesionectomy of a variety of epileptogenic focuses (hypothalamic hamartomas, cortical dysplasias, cortical malformations, tubers) or as a disconnection tool allowing a new option of treatment without the hassles of an open surgery.

Methods

MRI-guided laser interstitial thermal therapy (MRgLITT) is a procedure for destroying tissue-using heat. To deliver this energy in a minimally invasive fashion, a small diameter fiber optic applicator is inserted into the lesion through a keyhole stereotactic procedure. The thermal energy induces damage to intracellular DNA and DNA-binding structures, ultimately leading to cell death. The ablation procedure is supervised by real-time MRI thermal mapping and confirmed by immediate post-ablation T1 or FLAIR MRI images.

Results

The present report includes an overview of the development and practice of an MR-guided laser ablation therapy known as MRI-guided laser interstitial thermal therapy (MRgLITT). The role of modern image-guided trajectory planning in MRgLITT will also be discussed, with particular emphasis on the treatment of refractory epilepsy using this novel, minimally invasive technique.

Conclusion

MRI-guided laser-induced thermal ablation for epilepsy is an exciting new minimally invasive technology that finds potential new applications every day in the neurosurgical field. It certainly brings a new perspective on the way we practice epilepsy surgery even though long-term results should be properly collected and analyzed.
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Metadata
Title
The use of MRI-guided laser-induced thermal ablation for epilepsy
Authors
Zulma Tovar-Spinoza
David Carter
David Ferrone
Yaman Eksioglu
Sean Huckins
Publication date
01-11-2013
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 11/2013
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-013-2169-6

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