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Heart and Vessels
Published in: Heart and Vessels 10/2022

Open Access 09-05-2022 | Aortic Valve Replacement | Original Article

The early and long-term outcomes of coronary artery bypass grafting added to aortic valve replacement compared to isolated aortic valve replacement in elderly patients: a systematic review and meta-analysis

Authors: Stefano D’Alessandro, Domenico Tuttolomondo, Gurmeet Singh, Daniel Hernandez-Vaquero, Claudia Pattuzzi, Alan Gallingani, Francesco Maestri, Francesco Nicolini, Francesco Formica

Published in: Heart and Vessels | Issue 10/2022

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Abstract

In aged population, the early and long-term outcomes of coronary revascularization (CABG) added to surgical aortic valve replacement (SAVR) compared to isolated SAVR (i-SAVR) are conflicting. To address this limitation, a meta-analysis comparing the early and late outcomes of SAVR plus CABG with i-SAVR was performed. Electronic databases from January 2000 to November 2021 were screened. Studies reporting early-term and long-term comparison between the two treatments in patients over 75 years were analyzed. The primary endpoints were in-hospital/30-day mortality and overall long-term survival. The pooled odd ratio (OR) and hazard ratio (HR) with 95% confidence interval (CI) were calculated for in-early outcome and long-term survival, respectively. Random-effect model was used in all analyses. Forty-four retrospective observational studies reporting on 74,560 patients (i-SAVR = 36,062; SAVR + CABG = 38,498) were included for comparison. The pooled analysis revealed that i-SAVR was significantly associated with lower rate of early mortality compared to SAVR plus CABG (OR = 0.70, 95% CI 0.66–0.75; p < 0.0001) and with lower incidence of postoperative acute renal failure (OR = 0.65; 95% CI 0.50–0.91; p = 0.02), need for dialysis (OR = 0.65; 95% CI 0.50–0.86; p = 0.002) and prolonged mechanical ventilation (OR = 0.57; 95% CI 0.42–0.77; p < 0.0001). Twenty-two studies reported data of long-term follow-up. No differences were reported between the two groups in long-term survival (HR = 0.95; 95% CI  0.87–1.03; p = 0.23). CABG added to SAVR is associated with worse early outcomes in terms of early mortality, postoperative acute renal failure, and prolonged mechanical ventilation. Long-term survival was comparable between the two treatments.
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Literature
1.
2.
3.
4.
Vahanian A, Beyersdorf F, Praz F, Milojevic M, Baldus S, Bauersachs J, Capodanno D, Conradi L, De Bonis M, De Paulis R, Delgado V, Freemantle N, Gilard M, Haugaa KH, Jeppsson A, Jüni P, Pierard L, Prendergast BD, Sádaba JR, Tribouilloy C, Wojakowski W, ESC/EACTS Scientific Document Group; ESC Scientific Document Group (2021) ESC/EACTS guidelines for the management of valvular heart disease. Eur J Cardiothorac Surg 60:727–800PubMedCrossRef
5.
Nikolaidis N, Pousios D, Haw MP, Kaarne M, Barlow CW, Livesey SA, Tsang GM, Ohri SK (2011) Long-term outcomes in octogenarians following aortic valve replacement. J Card Surg 26:466–471PubMedCrossRef
6.
Litmathe J, Boeken U, Feindt P, Gams E (2003) Concomitant CABG-procedures in elderly patients undergoing aortic valve replacement. An additional risk factor? Z Kardiol 92:947–952PubMedCrossRef
7.
Roberts WC, Ko JM, Filardo G, Kitchens BL, Henry AC, Hebeler RF Jr, Cheung EH, Matter GJ, Hamman BL (2007) Valve structure and survival in quadragenarians having aortic valve replacement for aortic stenosis (+/-aortic regurgitation) with versus without coronary artery bypass grafting at a single US medical center (1993 to 2005). Am J Cardiol 100:1683–1690PubMedCrossRef
8.
Harris RS, Yan TD, Black D, Black D, Bannon PG, Bayfield MS, Hendel PN, Wilson MK, Vallely MP (2013) Outcomes of surgical aortic valve replacement in octogenarians. Heart Lung Circ 22:618–626PubMedCrossRef
9.
Kuo K, Shah P, Hiebert B, Love K, Menkis AH, Manji RA, Arora RC (2017) Predictors of survival, functional survival, and hospital readmission in octogenarians after surgical aortic valve replacement. J Thorac Cardiovasc Surg 154:1544-1553.e1PubMedCrossRef
10.
Formica F, Mariani S, D’Alessandro S, Singh G, Di Mauro M, Cerrito MG, Messina LA, Scianna S, Papesso F, Sangalli F (2020) Does additional coronary artery bypass grafting to aortic valve replacement in elderly patients affect the early and long-term outcome? Heart Vessels 35:487–501PubMedCrossRef
11.
Folkmann S, Gorlitzer M, Weiss G, Harrer M, Thalmann M, Poslussny P, Grabenwoger M (2010) Quality of life in octogenarians one year after aortic valve replacement with or without coronary artery bypass surgery. Interact Cardiovasc Thorac Surg 11:750–753PubMedCrossRef
12.
Kolh P, Kerzmann A, Honore C, Comte L, Limet R (2007) Aortic valve surgery in octogenarians: predictive factors for operative and long-term results. Eur J Cardiothorac Surg 31:600–606PubMedCrossRef
13.
Likosky DS, Sorensen MJ, Dacey LJ, Baribeau YR, Leavitt BJ, Di Scipio AW, Hernandez Jr F, Cochran RP, Quinn R, Helm RE, Charlesworth DC, Clough RA, Malenka DJ, Sisto DA, Sardella G, Olmstead EM, Ross CS, O’Connor GT, Northern New England Cardiovascular Disease Study Group (2009) Long-term survival of the very elderly undergoing aortic valve surgery. Circulation 120(11 Suppl):S127–S133PubMed
14.
Langanay T, Flécher E, Fouquet O, Ruggieri VG, De La Tour B, Félix C, Lelong B, Verhoye JP, Corbineau H, Leguerrier A (2012) Aortic valve replacement in the elderly: the real life. Ann Thorac Surg 93:70–77PubMedCrossRef
15.
Agarwal S, Garg A, Parashar A, Svensson LG, Tuzcu EM, Navia JL, Mick S, Kapadia SR (2015) In-hospital mortality and stroke after surgical aortic valve replacement: a nationwide perspective. J Thorac Cardiovasc Surg 150:571–8.e8PubMedCrossRef
16.
Dimagli A, Sinha S, Caputo M, Angelini GD, Benedetto U (2020) Trend in morbidity and mortality in surgical aortic valve re-placement: a retrospective, observational, single centre study. Interact Cardiovasc Thorac Surg 31:796–802PubMedPubMedCentralCrossRef
17.
Chiappini B, Camurri N, Loforte A, Di Marco L, Di Bartolomeo R, Marinelli G (2004) Outcome after aortic valve replacement in octogenarians. Ann Thorac Surg 78:85–89PubMedCrossRef
18.
Dell’Amore A, Aquino TM, Pagliaro M, Lamarra M, Zussa C (2012) Aortic valve replacement with and without combined coronary bypass grafts in very elderly patients: early and long-term results. Eur J Cardiothorac Surg 41:491–498PubMedCrossRef
19.
Krane M, Voss B, Hiebinger A, Deutsch MA, Wottke M, Hapfelmeier A, Badiu CC, Bauernschmitt R, Lange R (2011) Twenty years of cardiac surgery in patients aged 80 years and older: risks and benefits. Ann Thorac Surg 91:506–513PubMedCrossRef
20.
Melby SJ, Zierer A, Kaiser SP, Guthrie TJ, Keune JD, Schuessler RB, Pasque MK, Lawton JS, Moazami N, Moon MR, Damiano RJ Jr (2007) Aortic valve replacement in octogenarians: risk factors for early and late mortality. Ann Thorac Surg 83:1651–1656PubMedCrossRef
21.
Grau JB, Mak AW, Ferrari G, Johnson CK, Shaw RE, Sperling J, Brizzio ME, Zapolanski A (2014) Perioperative predictors of mid-term survival after aortic valve replacement. Asian Cardiovasc Thorac Ann 22:566–573PubMedCrossRef
22.
Moher D, Liberati A, Tetzlaff J, Altman DG (2009) PRISMA Group. Preferred reporting items for systematic reviews and me-ta-analyses: the PRISMA statement. Open Med 3:e123–e130PubMedPubMedCentral
23.
Luo D, Wan X, Liu J, Tong T (2018) Optimally estimating the sample mean from the sample size, median, mid-range, and/or mid-quartile range. Stat Methods Med Res 27:1785–1805PubMedCrossRef
24.
Tierney JF, Stewart LA, Ghersi D, Burdett S, Sydes MR (2007) Practical methods for incorporating summary time-to-event data into meta-analysis. Trials 8:16PubMedPubMedCentralCrossRef
25.
Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539–1558PubMedCrossRef
26.
Viechtbauer W, Cheung MW (2010) Outlier and influence diagnostics for meta-analysis. Res Synth Methods 1:112–125PubMedCrossRef
27.
Thulin LI, Sjogren JL (2000) Aortic valve replacement with and without concomitant coronary artery bypass surgery in the elderly: risk factors related to long-term survival. Croat Med J 41:406–409PubMed
28.
Ennker J, Mortasawi A, Gehle S, Yaghmaie M, Schröder T, Rosendahl U, Ennker IC (2001) Aortic valve replacement with or with-out concomitant coronary artery bypass grafting in the ninth decade of life. Langenbecks Arch Surg 386:272–277PubMedCrossRef
29.
Brunvand H, Offstad J, Nitter-Hauge S, Svennevig JL (2002) Coronary artery bypass grafting combined with aortic valve replacement in healthy octogenarians does not increase postoperative risk. Scand Cardiovasc J 36:297–301PubMedCrossRef
30.
Lam BK, Hendry PJ (2004) Patients over 80 years: quality of life after aortic valve replacement. Age Ageing 33:307–309PubMedCrossRef
31.
Unic D, Leacche M, Paul S, Rawn JD, Aranki SF, Couper GS, Mihaljevic T, Rizzo RJ, Cohn LH, O’Gara PT, Byrne JG (2005) Early and late results of isolated and combined heart valve surgery in patients > or =80 years of age. Am J Cardiol 95:1500–1503PubMedCrossRef
32.
Urso S, Sadaba R, Greco E, Pulitani I, Alvarez L, Juaristi A, Goiti JJ (2007) One-hundred aortic valve replacements in octogenarians: outcomes and risk factors for early mortality. J Heart Valve Dis 16:139–144PubMed
33.
34.
Huber CH, Goeber V, Berdat P, Carrel T, Eckstein F (2007) Benefits of cardiac surgery in octogenarians—a postoperative quality of life assessment. Eur J Cardiothorac Surg 31:1099–1105PubMedCrossRef
35.
Ngaage DL, Cowen ME, Griffin S, Guvendik L, Cale AR (2008) Early neurological complications after coronary artery bypass grafting and valve surgery in octogenarians. Eur J Cardiothorac Surg 33:653–659PubMedCrossRef
36.
Filsoufi F, Rahmanian PB, Castillo JG, Chikwe J, Silvay G, Adams DH (2008) Excellent early and late outcomes of aortic valve replacement in people aged 80 and older. J Am Geriatr Soc 56:255–261PubMedCrossRef
37.
Maillet JM, Somme D, Hennel E, Lessana A, Saint-Jean O, Brodaty D (2009) Frailty after aortic valve replacement (AVR) in octogenarians. Arch Gerontol Geriatr 48:391–396PubMedCrossRef
38.
Florath I, Albert A, Boening A, Ennker IC, Ennker J (2010) Aortic valve replacement in octogenarians: identification of high-risk patients. Eur J Cardiothorac Surg 37:1304–1310PubMedCrossRef
39.
Maslow A, Casey P, Poppas A, Schwartz C, Singh A (2010) Aortic valve replacement with or without coronary artery bypass graft surgery: the risk of surgery in patients > or =80 years old. J Cardiothorac Vasc Anesth 24:18–24PubMedCrossRef
40.
Yamane K, Hirose H, Youdelman BA, Bogar LJ, Diehl JT (2011) Conventional aortic valve replacement for elderly patients in the current era. Circ J 75:2692–2698PubMedCrossRef
41.
Kesavan S, Iqbal A, Khan Y, Hutter J, Pike K, Rogers C, Turner M, Townsend M, Baumbach A (2011) Risk profile and outcomes of aortic valve replacement in octogenarians. World J Cardiol 3:359–366PubMedPubMedCentralCrossRef
42.
Raja SG, Navaratnarajah M, Husain M, Walker CP, Ilsley CD, Bahrami TT, Gaer JA, Amrani M (2013) Impact of concomitant coronary artery bypass grafting on in-hospital outcome in octogenarians undergoing aortic valve replacement. J Heart Valve Dis 22:177–183PubMed
43.
Abel NJ, Rogal GJ, Burns P, Saunders CR, Chamberlain RS (2013) Aortic valve replacement with and without coronary artery by-pass graft surgery in octogenarians: is it safe and feasible? Cardiology 124:163–173PubMedCrossRef
44.
Mitchell AE, Mitchell IM (2013) The hidden risks of advancing age and concomitant ischemic heart disease after aortic valve re-placement. Clin Cardiol 36:129–132PubMedPubMedCentralCrossRef
45.
Sasaki Y, Hirai H, Hosono M, Bito Y, Nakahira A, Suehiro Y, Kaku D, Okada Y, Suehiro S (2013) Adding coronary artery bypass grafting to aortic valve replacement increases operative mortality for elderly (70 years and older) patients with aortic steno-sis. Gen Thorac Cardiovasc Surg 61:626–631PubMedCrossRef
46.
Davis JP, LaPar DJ, Crosby IK, Kern JA, Lau CL, Kron IL, Ailawadi G (2014) Nonagenarians undergoing cardiac surgery. J Card Surg 29:600–604PubMedCrossRef
47.
Ho E, Mathur MN, Brady PW, Marshman D, Brereton RJ, Ross DE, Bhindi R, Hansen PS (2014) Surgical aortic valve replacement in very elderly patients aged 80 years and over: evaluation of early clinical outcomes. Heart Lung Circ 23:242–248PubMedCrossRef
48.
Kamiya H, Tanzeem N, Akhyari P, Pedraza A, Kallenbach K, Lichtenberg A, Karck M (2014) Impact of severe postoperative complications after cardiac surgery on mortality in patients aged over 80 years. Ann Thorac Cardiovasc Surg 20:383–389PubMedCrossRef
49.
Budniak W, Buczkowski P, Perek B, Katyńska I, Jemielity M (2014) Early and long-term results of cardiosurgical treatment of coronary artery disease and aortic stenosis in patients over 80 years old. Kardiochir Torakochirurgia Pol 11:246–251PubMedPubMedCentral
50.
Salsano A, Regesta T, Viganò G, Rapetto F, Boeddu S, Sportelli E, Pansini S, Risso P, Onorati F, Passerone G, Santini F (2016) Expectation and quality of life after aortic valve replacement over 85 years of age match those of the contemporary general population. Int J Artif Organs 39:56–62PubMedCrossRef
51.
Wang TK, Choi DH, Ramanathan T, Ruygrok PN (2017) Aortic valve replacement with or without concurrent coronary artery bypass grafting in octogenarians: eight-year cohort study. Heart Lung Circ 26:82–87PubMedCrossRef
52.
Ennker J, Zadeh B, Pons-Kuehnemann J, Niemann B, Grieshaber P, Ennker IC, Boening A (2018) Stentless bioprostheses for aortic valve replacement in octogenarians: the influence of coronary artery disease. Thorac Cardiovasc Surg 66:322–327PubMedCrossRef
53.
Takagi K, Arinaga K, Takaseya T, Otsuka H, Shojima T, Shintani Y, Zaima Y, Saku K, Oryoji A, Hiromatsu S (2020) Aortic valve replacement with or without concomitant coronary artery bypass grafting in very elderly patients aged 85 years and older. Heart Vessels 35:1409–1418PubMedCrossRef
54.
55.
Iung B, Vahanian A (2011) Epidemiology of valvular heart disease in the adult. Nat Rev Cardiol 8:162–172PubMedCrossRef
56.
Barreto-Filho JA, Wang Y, Dodson JA, Desai MM, Sugeng L, Geirsson A, Krumholz HM (2013) Trends in aortic valve replacement for elderly patients in the United States, 1999–2011. JAMA 310:2078–2085PubMedPubMedCentralCrossRef
57.
Vasques F, Lucenteforte E, Paone R, Mugelli A, Biancari F (2012) Outcome of patients aged >80 years undergoing combined aortic valve replacement and coronary artery bypass grafting: a systematic review and meta-analysis of 40 studies. Am Heart J 164:410-418.e1PubMedCrossRef
58.
Ashikhmina EA, Schaff HV, Dearani JA, Sundt TM 3rd, Suri RM, Park SJ, Burkhart HM, Li Z, Daly RC (2011) Aortic valve re-placement in the elderly: determinants of late outcome. Circulation 124:1070–1078PubMedCrossRef
59.
Croal BL, Hillis GS, Gibson PH, Fazal MT, El-Shafei H, Gibson G, Jeffrey RR, Buchan KG, West D, Cuthbertson BH (2006) Relationship between postoperative cardiac troponin I levels and outcome of cardiac surgery. Circulation 114:1468–1475PubMedCrossRef
60.
Domanski MJ, Mahaffey K, Hasselblad V, Brener SJ, Smith PK, Hillis G, Engoren M, Alexander JH, Levy JH, Chaitman BR, Broderick S, Mack MJ, Pieper KS, Farkouh ME (2011) Association of myocardial enzyme elevation and survival following coronary artery bypass graft surgery. JAMA 305:585–591PubMedCrossRef
61.
Smith CR, Leon MB, Mack MJ, Miller DC, Moses JW, Svensson LG, Tuzcu EM, Webb JG, Fontana GP, Makkar RR, Williams M, Dewey T, Kapadia S, Babaliaros V, Thourani VH, Corso P, Pichard AD, Bavaria JE, Herrmann HC, Akin JJ, Anderson WN, Wang D, Pocock SJ, PARTNER Trial Investigators (2011) Transcatheter versus surgical aortic-valve replacement in high-risk patients. N Engl J Med 364:2187–2198PubMedCrossRef
62.
Sondergaard L, Popma JJ, Reardon MJ, Van Mieghem NM, Deeb GM, Kodali S, George I, Williams MR, Yakubov SJ, Kappetein AP, Serruys PW, Grube E, Schiltgen MB, Chang Y, Engstrøm T, SURTAVI Trial Investigators (2019) Comparison of a complete percutaneous versus surgical approach to aortic valve replacement and revascularization in patients at intermediate surgical risk: results from the randomized SURTAVI trial. Circulation 140:1296–1305CrossRef
63.
Neumann FJ, Sousa-Uva M, Ahlsson A, Alfonso F, Banning AP, Benedetto U, Byrne RA, Collet JP, Falk V, Head SJ, Jüni P, Kastrati A, Koller A, Kristensen SD, Niebauer J, Richter DJ, Seferovic PM, Sibbing D, Stefanini GG, Windecker S, Yadav R, Zembala MO, ESC Scientific Document Group (2019) ESC/EACTS guidelines on myocardial revascularization. Eur Heart J 40:87–165PubMedCrossRef
64.
Fujita B, Ensminger S, Bauer T, Möllmann H, Beckmann A, Bekeredjian R, Bleiziffer S, Schäfer E, Hamm CW, Mohr FW, Katus HA, Harringer W, Walther T, Frerker C, GARY Executive Board (2018) Trends in practice and outcomes from 2011 to 2015 for surgical aortic valve replacement: an update from the German Aortic Valve Registry on 42 776 patients. Eur J Cardio-thorac Surg 53:552–559CrossRef
65.
Thalji NM, Suri RM, Daly RC, Greason KL, Dearani JA, Stulak JM, Joyce LD, Burkhart HM, Pochettino A, Li Z, Frye RL, Schaff HV (2015) The prognostic impact of concomitant coronary artery bypass grafting during aortic valve surgery: implications for revascularization in the transcatheter era. J Thorac Cardiovasc Surg 149:451–460PubMedCrossRef
66.
Patel KP, Michail M, Treibel TA, Rathod K, Jones DA, Ozkor M, Kennon S, Forrest JK, Mathur A, Mullen MJ, Lansky A, Baumbach A (2021) Coronary revascularization in patients undergoing aortic valve replacement for severe aortic stenosis. JACC Cardiovasc Interv 14:2083–2096PubMedCrossRef
67.
Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, Boriani G, Castella M, Dan GA, Dilaveris PE, Fauchier L, Filippatos G, Kalman JM, La Meir M, Lane DA, Lebeau JP, Lettino M, Lip GYH, Pinto FJ, Thomas GN, Valgimigli M, Van Gelder IC, Van Putte BP, Watkins CL, ESC Scientific Document Group (2021) 2020 ESC guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): the task force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J 42:373–498PubMedCrossRef
68.
Stone K, Fryer S, Faulkner J, Meyer ML, Heffernan K, Kucharska-Newton A, Zieff G, Paterson C, Matsushita K, Hughes TM, Tanaka H, Stoner L (2022) Associations of lower-limb atherosclerosis and arteriosclerosis with cardiovascular risk factors and disease in older adults: the atherosclerosis risk in communities (ARIC) study. Atherosclerosis 340:53–60PubMedCrossRef
69.
Axtell AL, Fiedler AG, Melnitchouk S, D’Alessandro DA, Villavicencio MA, Jassar AS, Sundt TM 3rd (2020) Correlation of cardiopulmonary bypass duration with acute renal failure after cardiac surgery. J Thorac Cardiovasc Surg 159:170–178CrossRef
70.
Brown JR, Kramer RS, MacKenzie TA, Coca SG, Sint K, Parikh CR (2012) Determinants of acute kidney injury duration after cardiac surgery: an externally validated tool. Ann Thorac Surg 93:570–576PubMedCrossRef
71.
Kumar AB, Suneja M, Bayman EO, Weide GD, Tarasi M (2012) Association between postoperative acute kidney injury and duration of cardiopulmonary bypass: a meta-analysis. J Cardiothorac Vasc Anesth 26:64–69PubMedCrossRef
72.
Ergüneş K, Yurekli I, Celik E, Yetkin U, Yilik L, Gurbuz A (2013) Predictors of intra-aortic balloon pump insertion in coronary surgery and mid-term results. Korean J Thorac Cardiovasc Surg 46:444–448PubMedPubMedCentralCrossRef
73.
Parissis H, Leotsinidis M, Akbar MT, Apostolakis E, Dougenis D (2010) The need for intra-aortic balloon pump support following open heart surgery: risk analysis and outcome. J Cardiothorac Surg 5:20PubMedPubMedCentralCrossRef
74.
Zainab A, Nguyen DT, Graviss EA, Fatima S, Masud FN, MacGillivray TE (2022) Development and validation of a risk score for respiratory failure after cardiac surgery. Ann Thorac Surg 113:577–584PubMedCrossRef
75.
Aksoy R, Karakoc AZ, Cevirme D, Elibol A, Yigit F, Yilmaz Ü, Rabus MB (2021) Predictive factors of prolonged ventilation following cardiac surgery with cardiopulmonary bypass. Braz J Cardiovasc Surg 36:780–787PubMedPubMedCentralCrossRef
76.
Sultan I, Bianco V, Kilic A, Jovin T, Jadhav A, Jankowitz B, Aranda-Michel E, D’angelo MP, Navid F, Wang Y, Thoma F, Gleason TG (2020) Predictors and outcomes of ischemic stroke after cardiac surgery. Ann Thorac Surg 110:448–456PubMedCrossRef
77.
Butler CG, Ho Luxford JM, Huang CC, Ejiofor JI, Rawn JD, Wilusz K, Fox JA, Shernan SK, Muehlschlegel JD (2017) Aortic atheroma increases the risk of long-term mortality in 20,000 patients. Ann Thorac Surg 104:1325–1331PubMedPubMedCentralCrossRef
Metadata
Title
The early and long-term outcomes of coronary artery bypass grafting added to aortic valve replacement compared to isolated aortic valve replacement in elderly patients: a systematic review and meta-analysis
Authors
Stefano D’Alessandro
Domenico Tuttolomondo
Gurmeet Singh
Daniel Hernandez-Vaquero
Claudia Pattuzzi
Alan Gallingani
Francesco Maestri
Francesco Nicolini
Francesco Formica
Publication date
09-05-2022
Publisher
Springer Japan
Published in
Heart and Vessels / Issue 10/2022
Print ISSN: 0910-8327
Electronic ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-022-02073-4

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