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Heart and Vessels

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30-03-2022 | Intravascular Ultrasound | Original Article

Relation of glucose variability to vulnerable plaque formation in patients with coronary artery disease

Authors: Kazuya Tateishi, Yuichi Saito, Hideki Kitahara, Yoshio Kobayashi

Published in: Heart and Vessels | Issue 9/2022

Abstract

Background

Although glucose variability (GV) is reportedly associated with coronary plaque vulnerability, namely lipid-rich plaque, details are not fully understood. The aim of this study was to evaluate relations of GV after discharge to vulnerable plaque formation assessed by near-infrared spectroscopy intravascular ultrasound (NIRS-IVUS) in patients with and without diabetes.

Methods

A total of 40 patients undergoing percutaneous coronary intervention under NIRS-IVUS guidance were included, among whom 13 (33%) had diabetes and 20 (50%) presented with acute myocardial infarction (MI). GV was evaluated by a flush glucose monitoring system, primarily with mean amplitude of glycemic excursion (MAGE). Lipid-rich plaque was assessed by maximum lipid core burden index in 4 mm (maxLCBI_4mm) in the target lesion using NIRS-IVUS.

Results

Mean MAGE and maxLCBI_4mm were 69.7 ± 25.6 mg/dl and 508.0 ± 294.9. Intra-day GV was not significantly associated with maxLCBI_4mm in the entire study population, while MAGE was correlated with maxLCBI_4mm in non-diabetic patients (r = 0.46, p = 0.02). In patients with and without acute MI presentation, no significant relations were found between MAGE and maxLCBI_4mm.

Conclusion

GV was associated with lipid core plaque formation, especially in non-diabetic patients.

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Title: Relation of glucose variability to vulnerable plaque formation in patients with coronary artery disease
Authors: Kazuya Tateishi
Yuichi Saito
Hideki Kitahara
Yoshio Kobayashi
Publication date: 30-03-2022
Publisher: Springer Japan
Keywords: Intravascular Ultrasound
Myocardial Infarction
Arterial Diseases
Diabetes
Published in: Heart and Vessels / Issue 9/2022
Print ISSN: 0910-8327
Electronic ISSN: 1615-2573
DOI: https://doi.org/10.1007/s00380-022-02063-6

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