Implication of urine aquaporin-2 levels following cardiac surgery

Excerpt

In addition to the renin-angiotensin-aldosterone system and the sympathetic nerve system, the arginine vasopressin system is receiving great concern as a therapeutic target in patients with cardiovascular disease. Fujii and colleagues demonstrated that both plasma arginine vasopressin and urine aquaporin-2 levels were elevated immediately after the surgical aortic valve replacement [1]. Both variables had a positive correlation with each other. They hypothesized that a urine aquaporin-2 level might be a potential biomarker of perioperative cardiac dysfunction. Several concerns should improve the implication of their findings. …