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Published in: Heart and Vessels 9/2017

01-09-2017 | Original Article

Cardiac hyaluronan may be associated with the persistence of atrial fibrillation

Authors: Ayako Okada, Yuichiro Kashima, Takeshi Tomita, Takahiro Takeuchi, Yasutaka Oguchi, Koji Yoshie, Wataru Shoin, Morio Shoda, Kenichi Nitta, Koichiro Kuwahara, Hiroshi Imamura

Published in: Heart and Vessels | Issue 9/2017

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Abstract

Hyaluronan (HA), a primary component of the extracellular matrix, is associated with several cardiovascular diseases. However, its precise cardiac origin and role in atrial fibrillation (AF) remain unclear. We investigated chamber-specific HA levels in patients with paroxysmal AF (PAF) or persistent AF (PSAF). The levels of HA, a diacron-reactive oxygen metabolite (dROM) as a marker for oxidative stress, at different cardiac sites, and peripheral brain natriuretic peptide (BNP) levels were measured in patients with PAF (n = 50) or PSAF (n = 35). HA levels in the coronary sinus (CS-HA) were significantly higher than those other sites, in both PAF and PSAF patients, and CS-HA levels were significantly higher in PSAF patients than in PAF patients [37.1 (interquartile range, 31.2–48.3) vs. 30.6 (23.7–40.2) pg/mL, P < 0.01]. CS-HA levels were correlated with CS-dROM levels and peripheral BNP levels in PSAF patients (r = 0.417, P = 0.03 and r = 0.579, P < 0.001, respectively), but not in PAF patients (r = −0.115, P = 0.421 and r = 0.048, P = 0.740, respectively). CS-HA levels were elevated in both PAF and PSAF patients and were correlated with cardiac oxidative stress and BNP levels in PSAF patients. Cardiac HA may be associated with the persistence of AF.
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Metadata
Title
Cardiac hyaluronan may be associated with the persistence of atrial fibrillation
Authors
Ayako Okada
Yuichiro Kashima
Takeshi Tomita
Takahiro Takeuchi
Yasutaka Oguchi
Koji Yoshie
Wataru Shoin
Morio Shoda
Kenichi Nitta
Koichiro Kuwahara
Hiroshi Imamura
Publication date
01-09-2017
Publisher
Springer Japan
Published in
Heart and Vessels / Issue 9/2017
Print ISSN: 0910-8327
Electronic ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-017-0972-9

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