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01-04-2016 | Original Article

Assessment of vascular response after drug-eluting stents implantation in patients with diabetes mellitus: an optical coherence tomography sub-study of the J-DESsERT

Authors: Takashi Kubo, Takashi Akasaka, Takashi Tanimoto, Masamichi Takano, Yoshitane Seino, Kenya Nasu, Tomonori Itoh, Kyoichi Mizuno, Hiroyuki Okura, Toshiro Shinke, Jun-ichi Kotani, Shigenori Ito, Hiroyoshi Yokoi, Toshiya Muramatsu, Masato Nakamura, Shinsuke Nanto

Published in: Heart and Vessels | Issue 4/2016

Abstract

Even in the drug-eluting stent era, diabetes mellitus (DM) patients have high incidences of restenosis and repeat revascularization after percutaneous coronary intervention. The aim of this study was to compare vascular response after stent implantation between sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) by using optical coherence tomography (OCT) in DM patients as well as in non-DM patients. In the Japan-Drug Eluting Stents Evaluation; a Randomized Trial (J-DESsERT), the OCT sub-study enrolled 75 patients who underwent 8 months follow-up imaging after SES or PES implantation. Mean neointimal hyperplasia (NIH) thickness was significantly thinner in SES than PES in the DM group (77 ± 47 vs. 201 ± 114 μm, p < 0.001) and in the non-DM group (84 ± 37 vs. 212 ± 128 μm, p < 0.001). Unevenness of NIH thickness in longitudinal axis was significantly smaller in SES than PES in the DM group (348 ± 191 vs. 726 ± 385 μm, p < 0.001) and in the non-DM group (344 ± 174 vs. 679 ± 314 μm, p < 0.001). The percentage of uncovered struts was significantly greater in SES than PES in the DM group (24 ± 4 vs. 9 ± 14 %, p < 0.001) and in the non-DM group (16 ± 16 vs. 3 ± 4 %, p = 0.002). Compared with PES, SES showed more potent NIH inhibition in DM patients as well as in non-DM patients.

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Title: Assessment of vascular response after drug-eluting stents implantation in patients with diabetes mellitus: an optical coherence tomography sub-study of the J-DESsERT
Authors: Takashi Kubo
Takashi Akasaka
Takashi Tanimoto
Masamichi Takano
Yoshitane Seino
Kenya Nasu
Tomonori Itoh
Kyoichi Mizuno
Hiroyuki Okura
Toshiro Shinke
Jun-ichi Kotani
Shigenori Ito
Hiroyoshi Yokoi
Toshiya Muramatsu
Masato Nakamura
Shinsuke Nanto
Publication date: 01-04-2016
Publisher: Springer Japan
Published in: Heart and Vessels / Issue 4/2016
Print ISSN: 0910-8327
Electronic ISSN: 1615-2573
DOI: https://doi.org/10.1007/s00380-015-0636-6

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