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Published in: Heart and Vessels 5/2015

01-09-2015 | Original Article

Impact of combined lipid lowering with blood pressure control on coronary plaque regression: rationale and design of MILLION study

Authors: Masa-aki Kawashiri, Kenji Sakata, Tadatsugu Gamou, Honin Kanaya, Kenji Miwa, Kosei Ueda, Toshinori Higashikata, Sumio Mizuno, Ichiro Michishita, Masanobu Namura, Yutaka Nitta, Shoji Katsuda, Kazuyasu Okeie, Hiroaki Hirase, Hayato Tada, Katsuharu Uchiyama, Tetsuo Konno, Kenshi Hayashi, Hidekazu Ino, Keisuke Nagase, Mitsuyasu Terashima, Masakazu Yamagishi

Published in: Heart and Vessels | Issue 5/2015

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Abstract

A line of epidemiological studies suggests that the accumulation of coronary risk factors promotes the progression of coronary atherosclerosis. Recent clinical studies showed that aggressive low-density lipoprotein (LDL) cholesterol-lowering therapy using statins could regress coronary atheroma and reduce major cardiovascular events. Additionally, therapy that controlled amlodipine-based blood pressure reduced major cardiovascular events in patients with hypertension compared with an atenolol-based regimen. An open-label randomized multicenter study is primarily planned to evaluate the changes in coronary atheroma volume using intravascular ultrasonography 18–24 months after intensive lowering of LDL-cholesterol and blood pressure compared with a standard therapy indicated by current guidelines in Japanese patients with coronary artery disease (CAD). The secondary endpoints include changes in serum lipid levels, inflammatory markers, glucose markers and blood pressure. In total, 100 subjects with CAD who are undergoing percutaneous coronary intervention will be tested. The MILLION study will provide new evidence and therapeutic standards for the prevention of CAD in Japanese patients by controlling both LDL-C levels and blood pressure.
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Metadata
Title
Impact of combined lipid lowering with blood pressure control on coronary plaque regression: rationale and design of MILLION study
Authors
Masa-aki Kawashiri
Kenji Sakata
Tadatsugu Gamou
Honin Kanaya
Kenji Miwa
Kosei Ueda
Toshinori Higashikata
Sumio Mizuno
Ichiro Michishita
Masanobu Namura
Yutaka Nitta
Shoji Katsuda
Kazuyasu Okeie
Hiroaki Hirase
Hayato Tada
Katsuharu Uchiyama
Tetsuo Konno
Kenshi Hayashi
Hidekazu Ino
Keisuke Nagase
Mitsuyasu Terashima
Masakazu Yamagishi
Publication date
01-09-2015
Publisher
Springer Japan
Published in
Heart and Vessels / Issue 5/2015
Print ISSN: 0910-8327
Electronic ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-014-0522-7

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