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Published in: Heart and Vessels 4/2011

01-07-2011 | Original Article

Survival and changes in physical ability after coronary revascularization for octa-nonagenerian patients with acute coronary syndrome

Authors: Kuniyuki Shirasawa, Myung-Woo Hwang, Yoshio Sasaki, Shinichi Takeda, Katsura Inenaga-Kitaura, Yasushi Kitaura, Chuichi Kawai

Published in: Heart and Vessels | Issue 4/2011

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Abstract

Elderly populations are increasingly represented among patients with acute coronary syndrome (ACS), and advanced age has been identified as an important risk factor for death and adverse outcome in patients with ACS treated invasively. Although considerable data have demonstrated a prognostic benefit of early revascularization in ACS particularly in high-risk patients, elderly patients with ACS are treated invasively less often than younger patients because older age is thought to be an independent predictor of mortality after percutaneous coronary intervention (PCI) in ACS. Over the past 5 years, a total of 54 ACS patients over 85 years old were treated. The 6-month survival rate was around 50% in the non-PCI group (n = 12) and around 80% in the PCI group (n = 42) (P < 0.05). Cardiac death occurred in 6 patients in the PCI group and in 6 patients in the non-PCI group. The rates of both cardiac death and all-cause death were significantly lower in the PCI group. The change in ADL score before and 6 months after the procedure was from 1.57 to 1.59 in the PCI group and from 2.25 to 2.20 in the non-PCI group. PCI for elderly patients with ACS is safe and life saving, and does not reduce the ability to perform activities of daily living. PCI should be recommended even for octo-nonagenerians with ACS.
Literature
1.
go back to reference Bach RG, Cannon CP, Weintraub WS, DiBattiste PM, Demopoulos LA, Anderson HV, DeLucca PT, Mahoney EM, Murphy SA, Braunwald E (2004) The effect of routine, early invasive management on outcome for elderly patients with non-ST-segment elevation acute coronary syndromes. Ann Intern Med 141:186–195PubMed Bach RG, Cannon CP, Weintraub WS, DiBattiste PM, Demopoulos LA, Anderson HV, DeLucca PT, Mahoney EM, Murphy SA, Braunwald E (2004) The effect of routine, early invasive management on outcome for elderly patients with non-ST-segment elevation acute coronary syndromes. Ann Intern Med 141:186–195PubMed
2.
go back to reference Saejueng B, Yipintsoi T, Chaisuksuwan R, Kehasukcharoen W, Boonsom W, Kanjanavanit R, Representing the Thai ACS-Registry group (2009) Factors related to in-hospital heart failure are very different for unstable angina and non-ST elevation myocardial infarction. Heart Vessels 24:399–405PubMedCrossRef Saejueng B, Yipintsoi T, Chaisuksuwan R, Kehasukcharoen W, Boonsom W, Kanjanavanit R, Representing the Thai ACS-Registry group (2009) Factors related to in-hospital heart failure are very different for unstable angina and non-ST elevation myocardial infarction. Heart Vessels 24:399–405PubMedCrossRef
3.
go back to reference Wallentin L, Lagerqvist B, Husted S, Kontny F, Ståhle E, Swahn E (2000) Outcome at 1 year after an invasive compared with non-invasive strategy in unstable coronary-artery disease: the FRISC II invasive randomized trial. FRISC II investigators. Fast revascularization during instability in coronary artery disease. Lancet 356:9–16PubMedCrossRef Wallentin L, Lagerqvist B, Husted S, Kontny F, Ståhle E, Swahn E (2000) Outcome at 1 year after an invasive compared with non-invasive strategy in unstable coronary-artery disease: the FRISC II invasive randomized trial. FRISC II investigators. Fast revascularization during instability in coronary artery disease. Lancet 356:9–16PubMedCrossRef
4.
go back to reference Cannon CP, Weintraub WS, Demopoulos LA, Vicari R, Frey MJ, Lakkis N, Neumann FJ, Robertson DH, DeLucca PT, DiBattiste PM, Gibson CM, Braunwald E (2001) TACTICS (Treat Angina with Aggrastat and Determine Cost of Therapy with an Invasive or Conservative Strategy)—Thrombolysis in Myocardial Infarction 18 Investigators: comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban. N Engl J Med 344:1879–1887PubMedCrossRef Cannon CP, Weintraub WS, Demopoulos LA, Vicari R, Frey MJ, Lakkis N, Neumann FJ, Robertson DH, DeLucca PT, DiBattiste PM, Gibson CM, Braunwald E (2001) TACTICS (Treat Angina with Aggrastat and Determine Cost of Therapy with an Invasive or Conservative Strategy)—Thrombolysis in Myocardial Infarction 18 Investigators: comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban. N Engl J Med 344:1879–1887PubMedCrossRef
5.
go back to reference Spacek R, Widimský P, Straka Z, Jiresová E, Dvorák J, Polásek R, Karel I, Jirmár R, Lisa L, Budesínský T, Málek F, Stanka P (2002) Value of first day angiography/angioplasty in evolving non-ST segment elevation myocardial infarction: an open multicenter randomized trial. The VINO Study. Eur Heart J 23:230–238PubMedCrossRef Spacek R, Widimský P, Straka Z, Jiresová E, Dvorák J, Polásek R, Karel I, Jirmár R, Lisa L, Budesínský T, Málek F, Stanka P (2002) Value of first day angiography/angioplasty in evolving non-ST segment elevation myocardial infarction: an open multicenter randomized trial. The VINO Study. Eur Heart J 23:230–238PubMedCrossRef
6.
go back to reference Stone PH, Thompson B, Anderson HV, Kronenberg MW, Gibson RS, Rogers WJ, Diver DJ, Théroux P, Warnica JW, Nasmith JB, Kells C, Kleiman N, McCabe CH, Schactman M, Knatterud GL, Braunwald E (1996) Influence of race, sex, and age on management of unstable angina and non-Q-wave myocardial infarction: the TIMI III registry. JAMA 275:1104–1112PubMedCrossRef Stone PH, Thompson B, Anderson HV, Kronenberg MW, Gibson RS, Rogers WJ, Diver DJ, Théroux P, Warnica JW, Nasmith JB, Kells C, Kleiman N, McCabe CH, Schactman M, Knatterud GL, Braunwald E (1996) Influence of race, sex, and age on management of unstable angina and non-Q-wave myocardial infarction: the TIMI III registry. JAMA 275:1104–1112PubMedCrossRef
7.
go back to reference Giugliano RP, Camargo CA Jr, Lloyd-Jones DM, Zagrodsky JD, Alexis JD, Eagle KA, Fuster V, O’Donnell CJ (1998) Elderly patients receives less aggressive medical and invasive management of unstable angina: potential impact of practice guidelines. Arch Intern Med 158:1113–1120PubMedCrossRef Giugliano RP, Camargo CA Jr, Lloyd-Jones DM, Zagrodsky JD, Alexis JD, Eagle KA, Fuster V, O’Donnell CJ (1998) Elderly patients receives less aggressive medical and invasive management of unstable angina: potential impact of practice guidelines. Arch Intern Med 158:1113–1120PubMedCrossRef
8.
go back to reference Chauhan MS, Kuntz RE, Ho KL, Cohen DJ, Popma JJ, Carrozza JP, Baim DS, Cutlip DE (2001) Coronary artery stenting in the aged. J Am Coll Cardiol 37:856–862PubMedCrossRef Chauhan MS, Kuntz RE, Ho KL, Cohen DJ, Popma JJ, Carrozza JP, Baim DS, Cutlip DE (2001) Coronary artery stenting in the aged. J Am Coll Cardiol 37:856–862PubMedCrossRef
9.
go back to reference Cannon CP (2003) Elderly patients with acute coronary syndromes: higher risk and greater benefit from antiplatelet therapy and/or interventional therapies. Am J Geriatr Cardiol 12:259–262 (Review)PubMedCrossRef Cannon CP (2003) Elderly patients with acute coronary syndromes: higher risk and greater benefit from antiplatelet therapy and/or interventional therapies. Am J Geriatr Cardiol 12:259–262 (Review)PubMedCrossRef
10.
go back to reference McKay CR, Rich MW, Vlietstra RE, Kitzman DW, Fleg JL, Krumholz HM, Lakatta EG, Cooke JP, Cannon CP, Ezekowitz MD, Frohlich ED, Jalife J, Kass DA, Kottke BA, Muller JE, Saltin B, Shen WK, Somers VK (2000) Executive summary: pivotal research in cardiovascular syndromes in the elderly. Am J Geriatr Cardiol 9:243–250PubMedCrossRef McKay CR, Rich MW, Vlietstra RE, Kitzman DW, Fleg JL, Krumholz HM, Lakatta EG, Cooke JP, Cannon CP, Ezekowitz MD, Frohlich ED, Jalife J, Kass DA, Kottke BA, Muller JE, Saltin B, Shen WK, Somers VK (2000) Executive summary: pivotal research in cardiovascular syndromes in the elderly. Am J Geriatr Cardiol 9:243–250PubMedCrossRef
11.
go back to reference Hasdai D, Holmes DR Jr, Criger DA, Topol EJ, Califf RM, Harrington RA (2000) Age and outcome after acute coronary syndromes without persistent ST-segment elevation. Am Heart J 139:858–866PubMedCrossRef Hasdai D, Holmes DR Jr, Criger DA, Topol EJ, Califf RM, Harrington RA (2000) Age and outcome after acute coronary syndromes without persistent ST-segment elevation. Am Heart J 139:858–866PubMedCrossRef
12.
go back to reference De Servi S, Cavallini C, Dellavalle A, Santoro GM, Bonizzoni E, Marzocchi A, Politi A, Pesaresi A, Mariani M, Chierchia S (2004) ROSAI-2 Investigators: non-ST-elevation acute coronary syndrome in the elderly: treatment strategies and 30-day outcome. Am Heart J 147:830–836PubMedCrossRef De Servi S, Cavallini C, Dellavalle A, Santoro GM, Bonizzoni E, Marzocchi A, Politi A, Pesaresi A, Mariani M, Chierchia S (2004) ROSAI-2 Investigators: non-ST-elevation acute coronary syndrome in the elderly: treatment strategies and 30-day outcome. Am Heart J 147:830–836PubMedCrossRef
13.
go back to reference Graham MM, Ghali WA, Faris PD, Galbraith PD, Norris CM, Knudtson ML (2002) Alberta Provincial Project for Outcomes Assessment in Coronary Heart Disease (APPROACH) Investigators: survival after coronary revascularization in the elderly. Circulation 105:2378–2384PubMedCrossRef Graham MM, Ghali WA, Faris PD, Galbraith PD, Norris CM, Knudtson ML (2002) Alberta Provincial Project for Outcomes Assessment in Coronary Heart Disease (APPROACH) Investigators: survival after coronary revascularization in the elderly. Circulation 105:2378–2384PubMedCrossRef
14.
go back to reference Yun KH, Jeong MH, Oh SK, Rhee SJ, Park EM, Lee EM, Yoo NJ, Kim N-H, Ahn YK, Jeong J-W (2009) Response of high-sensitivity C-reactive protein to percutaneous coronary intervention in patients with acute coronary syndrome. Heart Vessels 24:175–180PubMedCrossRef Yun KH, Jeong MH, Oh SK, Rhee SJ, Park EM, Lee EM, Yoo NJ, Kim N-H, Ahn YK, Jeong J-W (2009) Response of high-sensitivity C-reactive protein to percutaneous coronary intervention in patients with acute coronary syndrome. Heart Vessels 24:175–180PubMedCrossRef
15.
go back to reference Smith SC Jr, Dove JT, Jacobs AK, Kennedy JW, Kereiakes D, Kern MJ, Kuntz RE, Popma JJ, Schaff HV, Williams DO, Gibbons RJ, Alpert JP, Eagle KA, Faxon DP, Fuster V, Gardner TJ, Gregoratos G, Russell RO, Smith SC Jr (2001) American College of Cardiology; American Heart Association Task Force on Practice Guidelines. Committee to Revise the 1993 Guidelines for Percutoneous Transluminal Coronary Angioplasty: ACC/AHA guidelines of percutaneous coronary interventions (revision of the 1993 PTCA guidelines)—executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (committee to revise the 1993 guidelines for percutaneous transluminal coronary angioplasty). J Am Coll Cardiol 37:2215–2239PubMedCrossRef Smith SC Jr, Dove JT, Jacobs AK, Kennedy JW, Kereiakes D, Kern MJ, Kuntz RE, Popma JJ, Schaff HV, Williams DO, Gibbons RJ, Alpert JP, Eagle KA, Faxon DP, Fuster V, Gardner TJ, Gregoratos G, Russell RO, Smith SC Jr (2001) American College of Cardiology; American Heart Association Task Force on Practice Guidelines. Committee to Revise the 1993 Guidelines for Percutoneous Transluminal Coronary Angioplasty: ACC/AHA guidelines of percutaneous coronary interventions (revision of the 1993 PTCA guidelines)—executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (committee to revise the 1993 guidelines for percutaneous transluminal coronary angioplasty). J Am Coll Cardiol 37:2215–2239PubMedCrossRef
16.
go back to reference O’Sullivan GJ, Buckenham TM, Belli AM (1999) The use of the angio-seal haemostatic puncture closure device in high risk patients. Clin Radiol 54:51–55PubMedCrossRef O’Sullivan GJ, Buckenham TM, Belli AM (1999) The use of the angio-seal haemostatic puncture closure device in high risk patients. Clin Radiol 54:51–55PubMedCrossRef
17.
go back to reference Feliciano J, Fiarresga AJ, Timóteo AT, Pelicano N, Cacela D, Ferreira R, Ferreira L, Gonçalves JM, Quininha J (2005) Primary coronary angioplasty in the elderly. Rev Port Cardiol 24(2):205–214PubMed Feliciano J, Fiarresga AJ, Timóteo AT, Pelicano N, Cacela D, Ferreira R, Ferreira L, Gonçalves JM, Quininha J (2005) Primary coronary angioplasty in the elderly. Rev Port Cardiol 24(2):205–214PubMed
18.
go back to reference Galasso G, Piscione F, Furbatto F, Leosco D, Pierri A, Rosa RD, Cirillo P, Rapacciuolo A, Esposito G, Chiariello M (2008) Abciximab in elderly with acute coronary syndrome invasively treated: effect on outcome. Int J Cardiol 130(3):380–385PubMedCrossRef Galasso G, Piscione F, Furbatto F, Leosco D, Pierri A, Rosa RD, Cirillo P, Rapacciuolo A, Esposito G, Chiariello M (2008) Abciximab in elderly with acute coronary syndrome invasively treated: effect on outcome. Int J Cardiol 130(3):380–385PubMedCrossRef
19.
go back to reference Walsh SJ, McAuley K, Johnston PW (2007) Percutaneous coronary intervention in the elderly. Ulster Med J 76(1):18–21PubMed Walsh SJ, McAuley K, Johnston PW (2007) Percutaneous coronary intervention in the elderly. Ulster Med J 76(1):18–21PubMed
20.
go back to reference Mehta RH, Sadiq I, Goldberg RJ, Gore JM, Avezum A, Spencer F, Kline-Rogers E, Allegrone J, Pieper K, Fox KA, Eagle KA (2004) GRACE Investigators: effectiveness of primary percutaneous coronary intervention compared with that of thrombolytic therapy in elderly patients with acute myocardial infarction. Am Heart J 147:253–259PubMedCrossRef Mehta RH, Sadiq I, Goldberg RJ, Gore JM, Avezum A, Spencer F, Kline-Rogers E, Allegrone J, Pieper K, Fox KA, Eagle KA (2004) GRACE Investigators: effectiveness of primary percutaneous coronary intervention compared with that of thrombolytic therapy in elderly patients with acute myocardial infarction. Am Heart J 147:253–259PubMedCrossRef
21.
go back to reference Bhatt DL, Roe MT, Peterson ED, Li Y, Chen AY, Harrington RA, Greenbaum AB, Berger PB, Cannon CP, Cohen DJ, Saucedo JF, Kleiman NS, Hochmen JS, Boden WE, Brindis RG, Peacock WF, Smith SC Jr, Pollack CV Jr, Gibler WB, Ohman EM (2004) CRUSADE Investigators: utilization of early invasive management strategies for high-risk patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE quality improvement initiative. JAMA 292:2096–2104PubMedCrossRef Bhatt DL, Roe MT, Peterson ED, Li Y, Chen AY, Harrington RA, Greenbaum AB, Berger PB, Cannon CP, Cohen DJ, Saucedo JF, Kleiman NS, Hochmen JS, Boden WE, Brindis RG, Peacock WF, Smith SC Jr, Pollack CV Jr, Gibler WB, Ohman EM (2004) CRUSADE Investigators: utilization of early invasive management strategies for high-risk patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE quality improvement initiative. JAMA 292:2096–2104PubMedCrossRef
Metadata
Title
Survival and changes in physical ability after coronary revascularization for octa-nonagenerian patients with acute coronary syndrome
Authors
Kuniyuki Shirasawa
Myung-Woo Hwang
Yoshio Sasaki
Shinichi Takeda
Katsura Inenaga-Kitaura
Yasushi Kitaura
Chuichi Kawai
Publication date
01-07-2011
Publisher
Springer Japan
Published in
Heart and Vessels / Issue 4/2011
Print ISSN: 0910-8327
Electronic ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-010-0067-3

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