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01-08-2018 | Original Article

Sarcopenia predicts 90-day mortality and postoperative complications after radical cystectomy for bladder cancer

Authors: Roman Mayr, Hans-Martin Fritsche, Florian Zeman, Marieke Reiffen, Leopold Siebertz, Christoph Niessen, Armin Pycha, Bas W. G. van Rhijn, Maximilian Burger, Michael Gierth

Published in: World Journal of Urology | Issue 8/2018

Abstract

Purpose

A single-center study was conducted to investigate the impact of sarcopenia as a predictor for 90-day mortality (90 dM) and complications within 90 days after radical cystectomy for bladder cancer.

Methods

In total, 327 patients with preoperative available digital computed tomography (CT) scans of the abdomen and pelvis were identified. The lumbar skeletal muscle index was measured using preoperative abdominal CT to assess sarcopenia. Complications were recorded and graded according to Clavien–Dindo (CD). Predictors of 90 dM and complications within 90 days were analyzed by uni- and multivariable logistic regression.

Results

Of the 327 patients, 262 (80%) were male and 108 (33%) patients were classified as sarcopenic. Within 90 days, 28 (7.8%) patients died, of whom 15 patients were sarcopenic and 13 were not. In multivariable logistic regression analysis, sarcopenia (OR 2.59; 95% CI 1.13–5.95; p = 0.025), ASA 3–4 (OR 2.53; 95% CI 1.10–5.82; p = 0.029) and cM + (OR 7.43; 95% CI 2.34–23.64; p = 0.001) were independent predictors of 90-day mortality. Sarcopenic patients experienced significantly more complications, i.e., CD 4a–5 (p = 0.003), compared to non-sarcopenic patients. In multivariable logistic regression analysis, sarcopenia was independently associated with CD ≥ 3b complications corrected for age, BMI, ASA-Score and type of urinary diversion.

Conclusions

We reported that sarcopenia proved an independent predictor for 90 dM and complications in patients undergoing RC for bladder cancer.

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Title: Sarcopenia predicts 90-day mortality and postoperative complications after radical cystectomy for bladder cancer
Authors: Roman Mayr
Hans-Martin Fritsche
Florian Zeman
Marieke Reiffen
Leopold Siebertz
Christoph Niessen
Armin Pycha
Bas W. G. van Rhijn
Maximilian Burger
Michael Gierth
Publication date: 01-08-2018
Publisher: Springer Berlin Heidelberg
Published in: World Journal of Urology / Issue 8/2018
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-018-2259-x

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Sarcopenia predicts 90-day mortality and postoperative complications after radical cystectomy for bladder cancer

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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