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01-03-2017 | Topic Paper

Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC)

Authors: Francesco Soria, Shahrokh F. Shariat, Seth P. Lerner, Hans-Martin Fritsche, Michael Rink, Wassim Kassouf, Philippe E. Spiess, Yair Lotan, Dingwei Ye, Mario I. Fernández, Eiji Kikuchi, Daher C. Chade, Marko Babjuk, Arthur P. Grollman, George N. Thalmann

Published in: World Journal of Urology | Issue 3/2017

Abstract

Purpose

Upper-tract urothelial carcinoma (UTUC) is a relatively uncommon disease with limited available evidence on specific topics. The purpose of this article was to review the previous literature to summarize the current knowledge about UTUC epidemiology, diagnosis, preoperative evaluation and prognostic assessment.

Methods

Using MEDLINE, a non-systematic review was performed including articles between January 2000 and February 2016. English language original articles, reviews and editorials were selected based on their clinical relevance.

Results

UTUC accounts for 5–10 % of all urothelial cancers, with an increasing incidence. UTUC and bladder cancer share some common risk factors, even if they are two different entities regarding practical, biological and clinical characteristics. Aristolochic acid plays an important role in UTUC pathogenesis in certain regions. It is further estimated that approximately 10 % of UTUC are part of the hereditary non-polyposis colorectal cancer spectrum disease. UTUC diagnosis remains mainly based on imaging and endoscopy, but development of new technologies is rapidly changing the diagnosis algorithm. To help the decision-making process regarding surgical treatment, extent of lymphadenectomy and selection of neoadjuvant systemic therapies, predictive tools based on preoperative patient and tumor characteristics have been developed.

Conclusions

Awareness regarding epidemiology, diagnosis, preoperative evaluation and prognostic assessment changes is essential to correctly diagnose and manage UTUC patients, thereby potentially improving their outcomes.

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Title: Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC)
Authors: Francesco Soria
Shahrokh F. Shariat
Seth P. Lerner
Hans-Martin Fritsche
Michael Rink
Wassim Kassouf
Philippe E. Spiess
Yair Lotan
Dingwei Ye
Mario I. Fernández
Eiji Kikuchi
Daher C. Chade
Marko Babjuk
Arthur P. Grollman
George N. Thalmann
Publication date: 01-03-2017
Publisher: Springer Berlin Heidelberg
Published in: World Journal of Urology / Issue 3/2017
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-016-1928-x

At a glance: The STEP trials

Springer Medicine

Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC)

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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