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01-02-2013 | Original Article

Upper urinary tract urothelial cell carcinoma: location as a predictive factor for concomitant bladder carcinoma

Authors: Marco Cosentino, Joan Palou, Josep M. Gaya, Alberto Breda, Oscar Rodriguez-Faba, Humberto Villavicencio-Mavrich

Published in: World Journal of Urology | Issue 1/2013

Abstract

Objective

To investigate the existence of predictive factors for concomitant, primary UUT-UCC and BC. Upper urinary tract urothelial cell carcinoma (UUT-UCC) is a pan-urothelial disease of the transitional epithelial cells. Although several studies have shown the association of bladder recurrence following UUT-UCC, little is known on the incidence of concomitant UUT-UCC and bladder cancer (BC) without previous BC.

Materials and methods

A retrospective review of 673 patients diagnosed and treated for UUT-UCC was performed. Patients with history of BC were excluded. We investigated age, sex, location of the upper tract tumor (calyx, renal pelvis, upper ureter, mid-ureter, lower ureter), multifocality, clinical symptoms, tumor grade and pathological stage. Contingency tables and chi-square test were used for categorical variables and analysis of variance (ANOVA) for quantitative variables.

Results

450 patients eligible for inclusion were identified. Of these, 76 (17 %) presented concomitant primary UUT-UCC and BC. Location of primary UUT-UCC was in calyx and/or renal pelvis in 25 patients (34 %), upper ureter 8 (11 %) and lower ureter 37 (49 %). In 6 patients (8 %), data were missing. Concomitant BC was found in 10, 18, and 33 % of patients with primary caliceal/renal pelvis, upper ureter and lower ureter UUT-UCC, respectively. On multivariate analysis, location of UUT-UCC was the only predictive factor for concomitant bladder tumor (OR: 1.7; 95 % CI, 1.007–2.906 p = 0.047).

Conclusions

Our findings suggest that the possibility of concomitant BC in primary diagnosed patient with UUT-UCC is as high as 33 % and mainly depends on upper tract tumor location.

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Title: Upper urinary tract urothelial cell carcinoma: location as a predictive factor for concomitant bladder carcinoma
Authors: Marco Cosentino
Joan Palou
Josep M. Gaya
Alberto Breda
Oscar Rodriguez-Faba
Humberto Villavicencio-Mavrich
Publication date: 01-02-2013
Publisher: Springer-Verlag
Published in: World Journal of Urology / Issue 1/2013
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-012-0877-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Upper urinary tract urothelial cell carcinoma: location as a predictive factor for concomitant bladder carcinoma

Abstract

Objective

Materials and methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusions

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