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World Journal of Urology
Published in: World Journal of Urology 2/2014

01-04-2014 | Original Article

Visceral obesity predicts adverse pathological features in urothelial bladder cancer patients undergoing radical cystectomy: a retrospective cohort study

Authors: Francesco Cantiello, Antonio Cicione, Riccardo Autorino, Andrea Salonia, Alberto Briganti, Matteo Ferro, Renato De Domenico, Sisto Perdonà, Rocco Damiano

Published in: World Journal of Urology | Issue 2/2014

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Abstract

Purpose

To evaluate the pathological characteristics of patients with metabolic syndrome (MetS) undergoing radical cystectomy (RC) for urothelial bladder cancer (BCa).

Methods

We retrospectively analyzed 262 consecutive patients with muscle-invasive urothelial BCa or non-muscle-invasive urothelial BCa bacillus Calmette-Guerin refractory undergoing RC with standard pelvic lymphadenectomy. The patients were stratified into those with or without MetS, and a bivariate logistic regression analysis was done to assess MetS and, separately, each single MetS component as independent predictors of higher pathological stage as well as of the presence of lymph vascular invasion (LVI) and lymph node metastasis (LM).

Results

Metabolic syndrome was found in 36.3 % of patients. At logistic regression analysis, the presence of MetS did not predict the risk of both higher pathological stage and LVI and LM. Investigating the single components of MetS after adjusting for age, gender, and smoking, the risk of higher pathological stage increased with body mass index [BMI (OR 1.307, 95 % CI 1.098–1.555)], waist circumference (OR 1.414, 95 % CI 1.364–1.668), and blood hypertension (OR 2.326, 95 % CI 1.147–4.717). Higher BMI also predicted the presence of LVI (OR 1.432, 95 % CI 1.173–1.748) and LM (OR 1.202, 95 % CI 0.951–1.519), whereas HDL cholesterol was inversely associated with the risk of LVI and LM.

Conclusions

Metabolic syndrome does not represent an independent risk factor for worse pathological findings in BCa. Conversely, individual components of MetS could increase the risk of higher stage as well as LM.
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Metadata
Title
Visceral obesity predicts adverse pathological features in urothelial bladder cancer patients undergoing radical cystectomy: a retrospective cohort study
Authors
Francesco Cantiello
Antonio Cicione
Riccardo Autorino
Andrea Salonia
Alberto Briganti
Matteo Ferro
Renato De Domenico
Sisto Perdonà
Rocco Damiano
Publication date
01-04-2014
Publisher
Springer Berlin Heidelberg
Published in
World Journal of Urology / Issue 2/2014
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-013-1147-7

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