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01-08-2011 | Topic paper

Current evidence for transurethral laser therapy of non-muscle invasive bladder cancer

Authors: Mario W. Kramer, Thorsten Bach, Mathias Wolters, Florian Imkamp, Andreas J. Gross, Markus A. Kuczyk, Axel S. Merseburger, Thomas R. W. Herrmann

Published in: World Journal of Urology | Issue 4/2011

Abstract

Introduction

Bladder cancer is the second most common malignancy of urologic tumors. Back in 1976, lasers were added to the endourological armetarium for bladder tumor treatment. Despite nowadays’ standard procedure for staging and treating non-muscle invasive bladder tumor by transurethral resection of bladder tumors (TURB) via a wire loop, laser resection techniques for bladder tumor came back in focus with the introduction of Ho:YAG and not to mention recently Tm:YAG lasers. This review aims to display the current evidence for these techniques.

Materials and methods

Throughout April 2010, MEDLINE and the Cochrane central register of controlled trials were searched previously for the following terms: “Laser, resection, ablation, coagulation, Nd:YAG Neodym, HoYAG: Holmium, Tm:YAG Thulium and transitional carcinoma, bladder, intravesical.”

Results

Eleven articles on Ho:YAG and 7 on Tm:YAG were identified. Searches by Cochrane online library resulted in no available manuscripts.

Conclusion

Today, Nd:YAG does not play any role in treatment of lower urinary tract transitional cell carcinoma. Ho:YAG and Tm:YAG seem to offer alternatives in the treatment of bladder cancer, but still to prove their potential in larger prospective randomized controlled studies with long-term follow-up. Future expectations will show whether en bloc resection of tumors are preferable to the traditional “incise and scatter” resection technique, in which is contrary to all oncological surgical principles. For the primary targets, here are within first-time clearance of disease, in addition to low in-fields and out-of-fields recurrence rates.

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Title: Current evidence for transurethral laser therapy of non-muscle invasive bladder cancer
Authors: Mario W. Kramer
Thorsten Bach
Mathias Wolters
Florian Imkamp
Andreas J. Gross
Markus A. Kuczyk
Axel S. Merseburger
Thomas R. W. Herrmann
Publication date: 01-08-2011
Publisher: Springer-Verlag
Published in: World Journal of Urology / Issue 4/2011
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-011-0680-5

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Current evidence for transurethral laser therapy of non-muscle invasive bladder cancer

Abstract

Introduction

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Introduction

Materials and methods

Results

Conclusion

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