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World Journal of Urology
Published in: World Journal of Urology 4/2007

01-08-2007 | Topic Paper

RETRACTED ARTICLE: Transurethral ultrasonography-guided injection of adult autologous stem cells versus transurethral endoscopic injection of collagen in treatment of urinary incontinence

Authors: H. Strasser, R. Marksteiner, E. Margreiter, M. Mitterberger, G. M. Pinggera, F. Frauscher, M. Fussenegger, K. Kofler, G. Bartsch

Published in: World Journal of Urology | Issue 4/2007

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Abstract

In the last years preclinical studies have paved the way for the use of adult muscle derived stem cells for reconstruction of the lower urinary tract. Between September 2002 and October 2004, 42 women and 21 men suffering from urinary stress incontinence (age 36–84 years) were recruited and subsequently treated with transurethral ultrasonography-guided injections of autologous myoblasts and fibroblasts obtained from skeletal muscle biopsies. The fibroblasts were injected into the urethral submucosa, while the myoblasts were implanted into the rhabdosphincter. In parallel, 7 men and 21 women (age 39–83 years) also diagnosed with urinary stress incontinence were treated with standard transurethral endoscopic injections of collagen. Patients were randomly assigned to both groups. After a follow-up of 12 months incontinence was cured in 39 women and 11 men after injection of autologous myoblasts and fibroblasts. Mean quality of life score (51.38 preoperatively, 104.06 postoperatively), thickness of urethra and rhabdosphincter (2.103 mm preoperatively, 3.303 mm postoperatively) as well as contractility of the rhabdosphincter (0.56 mm preoperatively, 1.462 mm postoperatively) were improved postoperatively. Only in two patients treated with injections of collagen incontinence was cured. The present clinical results demonstrate that, in contrast to injections of collagen, urinary incontinence can be treated effectively with ultrasonography-guided injections of autologous myo- and fibroblasts.
Literature
1.
Koelbl H, Mostwin J, Boiteux JP, Macarak E, Petri E, Schafer W, Yamaguchi O (2002) Pathophysiology. In: Abrams P, Cardozo L, Khoury S, Wein A (eds) Incontinence, 2nd International Consultation on Incontinence. Plymbridge Distributors Ltd, Plymouth
2.
Strasser H, Frauscher F, Helweg G, Colleselli K, Reissigl A, Bartsch G (1998) Transurethral ultrasound: evaluation of anatomy and function of the rhabdosphincter of the male urethra. J Urol 159:100–105CrossRefPubMed
3.
Frauscher F, Helweg G, Strasser H, Enna B, Klauser A, Knapp R, Colleselli K, Bartsch G, zur Nedden D (1998) Intraurethral ultrasound: diagnostic evaluation of the straited urethral sphincter in incontinent females. Eur Radiol 8:50–53CrossRefPubMed
4.
Colleselli K, Stenzl A, Eder R, Strasser H, Poisel S, Bartsch G (1998) The female urethral sphincter: a morphological and topographical study. J Urol 160:49–54CrossRefPubMed
5.
Strasser H, Klima G, Poisel S, Horninger W, Bartsch G (1996) Anatomy and innervation of the rhabdosphincter of the male urethra. Prostate 28:24–31CrossRefPubMed
6.
Strasser H, Ninkovic M, Hess M, Bartsch G, Stenzl A (2000) Anatomic and functional studies of the urethral rhabdosphincter. World J Urol 18:324–329CrossRefPubMed
7.
Strasser H, Tiefenthaler M, Steinlechner M, Bartsch G, Konwalinka G (1999) Urinary incontinence in the elderly and age-dependent apoptosis of rhabdosphincter cells. Lancet 354:918–919CrossRefPubMed
8.
Strasser H, Tiefenthaler M, Steinlechner M, Eder I, Bartsch G, Konwalinka G (2000) Age dependent apoptosis and loss of rhabdosphincter cells. J Urol 164:1781–1785CrossRefPubMed
9.
Perucchini D, DeLancey JO, Ashton-Miller JA, Peschers U, Kataria T (2002) Age effects on urethral striated muscle. I. Changes in number and diameter of striated muscle fibers in the ventral urethra. Am J Obstet Gynecol 186:351–355CrossRefPubMed
10.
Hunskaar S, Burgio K, Diokno AC, Herzog AR, Hjälmas K, Lapitan MC (2002) Epidemiology and natural history of urinary incontinence. In: Abrams P, Cardozo L, Khoury S, Wein A (eds) Incontinence, 2nd International Consultation on Incontinence. Plymbridge Distributors Ltd, Plymouth
11.
Smith T, Daneshagari F, Dmochowski R, Ghoniem G, Jarvis G, Nitti V, Paraiso M (2002) Surgical treatment of urinary incontinence in women. In: Abrams P, Cardozo L, Khoury S, Wein A (eds) Incontinence, 2nd International Consultation on Incontinence. Plymbridge Distributors Ltd, Plymouth
12.
Kiilholma PJ, Chancellor MB, Makinen J, Hirsch IH, Klemi PJ (1993) Complications of teflon injection for stress urinary incontinence. Neurourol Urodyn 12:131–137CrossRefPubMed
13.
Papa Petros PE (1994) Tissue reaction to implanted foreign materials for cure of stress incontinence. Am J Obstet Gynecol 171:1198–1204
14.
Noe HN, Williams RS, Causey J, Smith DP (1994) Long-term effects of polytetrafluoroethylene injected into the rat bladder submucosa. Urology 43:852–855CrossRefPubMed
15.
Mc Kinney CD, Gaffey MJ, Gillenwater JY (1995) Bladder outlet obstruction after multiple periurethral polytetrafluoroethylene injections. J Urol 153:149–151CrossRef
16.
Smith DP, Beegle BE, Noe HN, Wilson EA (1996) Does technique or material used affect bladder tissue reaction when injecting teflon or silicone paste? Urology 48:119–123CrossRefPubMed
17.
Sweat SD, Lightner DJ (1999) Complications of sterile abscess formation and pulmonary embolism following periurethral bulking agents. J Urol 161:93–96CrossRefPubMed
18.
Yonneau L, Chartier-Kastler E, Bohin D, Conort P, Bitker MO, Richard F (2000) Materials used in treatment of stress urinary incontinence with suburethral sling. Prog Urol 10:1238–1244PubMed
19.
Klutke C, Siegel S, Carlin B, Paszkiewicz E, Kirkemo A, Klutke J (2001) Urinary retention after tension-free vaginal tape procedure: incidence and treatment. Urology 58:697–701CrossRefPubMed
20.
Falconer C, Soderberg M, Blomgren B, Ulmsten U (2001) Influence of different sling materials on connective tissue metabolism in stress urinary incontinent women. Int Urogynecol J Pelvic Floor Dysfunct 12(Suppl 2):19–23CrossRef
21.
Pannek J, Brands FH, Senge T (2001) Particle migration after transurethral injection of carbon coated beads for stress urinary incontinence. J Urol 166:1350–1353CrossRefPubMed
22.
Guys JM, Fakhro A, Louis-Borrione C, Prost J, Hautier A (2001) Endoscopic treatment of urinary incontinence: long-term evaluation of the results. J Urol 165:2389–2391CrossRefPubMed
23.
Oberpfenning F, Meng J, Yoo JJ, Atala A (1999) De novo reconstruction of a functional mammalian urinary bladder by tissue engineering. Nat Biotechnol 17:149–155CrossRef
24.
Chancellor MB, Yokoyama T, Tirney S, Mattes CE, Ozawa H, Yoshimura N, de Groat WC, Huard J (2000) Preliminary results of myoblast injection into the urethra and bladder wall: a possible method for the treatment of stress urinary incontinence and impaired detrusor contractility. Neurourol Urodyn 19:279–287CrossRefPubMed
25.
Yokoyama T, Yoshimurs N, Dhir R, Qu Z, Fraser MO, Kumon H, de Groat WC, Huard J, Chancellor MB (2001) Persistence and survival of autologous muscle derived cells versus bovine collagen as potential treatment of stress urinary incontinence. J Urol 165:271–276CrossRefPubMed
26.
Yokoyama T, Huard J, Chancellor MB (2000) Myoblast therapy for stress urinary incontinence and bladder dysfunction. World J Urol 18:56–61CrossRefPubMed
27.
Strasser H, Marksteiner R, Margreiter E, Berjukow S, Klima G, Fritsch H, Pinggera GM, Rädler C, Bartsch G, Hering S (2003) Transurethral ultrasound guided injection of clonally cultured autologous myoblasts and fibroblasts: experimental results. J Urol 169(Suppl):37
28.
Groutz A, Blaivas JG, Rosenthal JE (2000) A simplified urinary incontinence score for the evaluation of treatment outcomes. Neurourol Urodyn 19:127–135CrossRefPubMed
29.
Patrick DL, Martin ML, Bushnell DM, Yalcin I, Wagner TH, Buesching DP (1999) Quality of life of women with urinary incontinence: further development of the incontinence quality of life instrument (I-QOL). Urology 53:71–76. Erratum in: Urology 53:1072CrossRefPubMed
30.
Batista J, Bauer S, Griffiths D, Hilton P, Kramer G, Lose G, Rosie PR (2002) Urodynamics. In: Abrams P, Cardozo L, Khoury S, Wein A (eds) Incontinence, 2nd International Consultation on Incontinence. Plymbridge Distributors Ltd, Plymouth
31.
Berjukow S, Margreiter E, Marksteiner R, Strasser H, Bartsch G, Hering S (2004) Membrane properties of single muscle cells of the rhabdosphincter of the male urethra. Prostate 58:238–247CrossRefPubMed
32.
Herschorn S, Bosch R, Bruschini H, Hanus T, Low A, Schick E (2002) Surgical treatment of urinary incontinence in men. In: Abrams P, Cardozo L, Khoury S, Wein A (eds) Incontinence, 2nd International Consultation on Incontinence. Plymbridge Distributors Ltd, Plymouth
33.
Arcila ME, Ameredes BT, de Rosimo JF, Washabaugh CH, Yang J, Johnson PC, Ontell M (1997) Mass and functional capacity of regenerating muscle is enhanced by myoblast transfer. J Neurobiol 33:185–198CrossRefPubMed
34.
Irintchev A, Langer M, Zweyer M, Theisen R, Wernig A (1997) Functional improvement of damaged adult mouse muscle by implantation of primary myoblasts. J Physiol 500:775–785PubMed
35.
Taylor DA, Atkins BZ, Hungspreugs P, Jones TR, Reedy MC, Hutcheson KA, Glower DD, Kraus WE (1998) Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nat Med 4:929–933CrossRefPubMed
36.
Law PK, Goodwin TG, Fang Q, Hall TL, Quinley T, Vastagh G, Duggirala V, Larkin C, Florendo JA, Li L, Jackson T, Yoo TJ, Chase N, Neel M, Krahn T, Holcomb R (1997) First human myoblast transfer therapy continues to show dystrophin after 6 years. Cell Transplant 6:95–100CrossRefPubMed
37.
Watson D, Keller GS, Lacombe V, Fodor PB, Rawnsley J, Lask GP (1999) Autologous fibroblasts for treatment of facial rhytids and dermal depressions. A pilot study. Arch Facial Plast Surg 1:165–170CrossRef
38.
Strasser H, Berjukow S, Marksteiner R, Margreiter E, Hering S, Bartsch G, Hering S (2004) Stem cell therapy for urinary stress incontinence. Exp Gerontol 39:1259–1265CrossRefPubMed
39.
Strasser H, Marksteiner R, Margreiter E, Pinggera GM, Mitterberger M, Fritsch H, Klima G, Radler C, Stadlbauer KH, Fussenegger M, Hering S, Bartsch G (2004) Stem cell therapy for urinary incontinence. Urologe A 43:1237–1241CrossRefPubMed
Metadata
Title
RETRACTED ARTICLE: Transurethral ultrasonography-guided injection of adult autologous stem cells versus transurethral endoscopic injection of collagen in treatment of urinary incontinence
Authors
H. Strasser
R. Marksteiner
E. Margreiter
M. Mitterberger
G. M. Pinggera
F. Frauscher
M. Fussenegger
K. Kofler
G. Bartsch
Publication date
01-08-2007
Publisher
Springer-Verlag
Published in
World Journal of Urology / Issue 4/2007
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-007-0190-7

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