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European Radiology
Published in: European Radiology 10/2020

01-10-2020 | Magnetic Resonance Imaging | Paediatric

MRI-based texture analysis for differentiating pediatric craniofacial rhabdomyosarcoma from infantile hemangioma

Authors: Fatma Ceren Sarioglu, Orkun Sarioglu, Handan Guleryuz, Erdener Ozer, Dilek Ince, Hatice Nur Olgun

Published in: European Radiology | Issue 10/2020

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Abstract

Objectives

To evaluate the diagnostic performance of MRI texture analysis (TA) for differentiation of pediatric craniofacial rhabdomyosarcoma (RMS) from infantile hemangioma (IH).

Methods

This study included 15 patients with RMS and 42 patients with IH who underwent MRI before an invasive procedure. All patients had a solitary lesion. T2-weighted and fat-suppressed contrast-enhanced T1-weighted axial images were used for TA. Two readers delineated the tumor borders for TA independently and evaluated the qualitative MRI characteristics in consensus. The differences of the texture features’ values between the groups were assessed and ROC curves were calculated. Logistic regression analysis was used to analyze the value of TA with and without the combination of the qualitative MRI characteristics. A p value < 0.05 was considered statistically significant.

Results

Thirty-eight texture features were calculated for each tumor. Eighteen features on T2-weighted images and 25 features on contrast-enhanced T1-weighted images were significantly different between the RMSs and IHs. On contrast-enhanced T1-weighted images, the short-zone emphasis (SZE), which was a gray-level zone length matrix (GLZLM) parameter, had the largest area under the curve: 0.899 (sensitivity 93%, specificity 87%). The independent predictor for the RMS among the qualitative MRI characteristics was heterogeneous contrast enhancement (p < 0.001). Using only a GLZLM_SZE value of lower than 0.72 was found to be the best diagnostic parameter in predicting RMS (p < 0.001; 95% CI, 8.770–992.4).

Conclusion

MRI-based TA may contribute to differentiate RMS from IH without invasive procedures.

Key Points

• Texture analysis may help to distinguish between rhabdomyosarcoma and infantile hemangioma without invasive procedures.
• The gray-level zone length matrix parameters, especially the short-zone emphasis, may be a potential predictor for rhabdomyosarcoma.
• Using contrast-enhanced T1-weighted images may be superior to T2-weighted images to differentiate rhabdomyosarcoma from infantile hemangioma in texture analysis.
Appendix
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Metadata
Title
MRI-based texture analysis for differentiating pediatric craniofacial rhabdomyosarcoma from infantile hemangioma
Authors
Fatma Ceren Sarioglu
Orkun Sarioglu
Handan Guleryuz
Erdener Ozer
Dilek Ince
Hatice Nur Olgun
Publication date
01-10-2020
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 10/2020
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-020-06908-4

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