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European Radiology
Published in: European Radiology 10/2020

01-10-2020 | Hepatocellular Carcinoma | Hepatobiliary-Pancreas

Prediction of HCC microvascular invasion with gadobenate-enhanced MRI: correlation with pathology

Authors: Ling Zhang, Xian Yu, WenXin Wei, XingPeng Pan, Lun Lu, JinJu Xia, Wei Zheng, Ningyang Jia, Lei Huo

Published in: European Radiology | Issue 10/2020

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Abstract

Purpose

To assess the accuracy of gadobenate-enhanced MRI for predicting microvascular invasion (MVI) in patients operated for hepatocellular carcinoma (HCC).

Methods

The 164 patients who met the inclusion criteria were assigned to one of two groups: the MVI-positive group and the MVI-negative group. Imaging results were compared between the two groups using the Kruskal test, chi-square test, independent sample t test, and logistic regression analysis.

Results

Differences in the capsule (p = 0.037) and margin (p = 0.004) of the tumor, rim enhancement (p = 0.002), peritumoral enhancement in the arterial phase (p < 0.001), and peritumoral hypointensity in the hepatobiliary phase (HBP) (p < 0.001) were statistically significant. The results of multivariate analysis identified rim enhancement in the arterial phase (odds ratio (OR) = 2.115; 95% confidence interval (CI), 1.002–4.464; p = 0.049) and peritumoral hypointensity in the HBP (OR = 5.836; 95% CI, 2.442–13.948; p < 0.001) as independent risk factors for MVI. Use of the two predictors in combination identified 32.79% (20/61) of HCCs with MVI with a specificity of 95.15% (98/103).

Conclusions

Rim enhancement in the arterial phase and peritumoral hypointensity in the HBP were identified as independent risk factors for MVI in patients with HCC.

Key Points

• Rim enhancement in the arterial phase and peritumoral hypointensity in the hepatobiliary phase were independent risk factors for microvascular invasion in patients with HCC.
• Use of the two predictors in combination had a sensitivity of 32.79% and a specificity of 95.15% for predicting microvascular invasion.
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Metadata
Title
Prediction of HCC microvascular invasion with gadobenate-enhanced MRI: correlation with pathology
Authors
Ling Zhang
Xian Yu
WenXin Wei
XingPeng Pan
Lun Lu
JinJu Xia
Wei Zheng
Ningyang Jia
Lei Huo
Publication date
01-10-2020
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 10/2020
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-020-06895-6

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