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01-01-2020 | Magnetic Resonance Imaging | Hepatobiliary-Pancreas

Can we differentiate HIV-associated obliterative portopathy from liver cirrhosis using MRI?

Authors: Esther Chouraqui, Laura Leguilloux, Anthony Dohan, Hervé Gouya, Matthias Barral, Anais Vallet-Pichard, Philippe Sogni, Stanislas Pol, Vincent Mallet, Philippe Soyer

Published in: European Radiology | Issue 1/2020

Abstract

Aim

To describe the magnetic resonance imaging (MRI) features of HIV-associated obliterative portopathy (HIV-OP) and determine the most indicative appearance of this condition on MRI by using a retrospective case-control study.

Methods

MRI examinations of 24 patients with HIV-OP (16 men, 8 women; mean age = 48 ± 6.6 [SD] years; age range, 35–71 years) were analyzed by two blinded observers and compared with those obtained in 18 HIV-infected patients with hepatic cirrhosis (14 men, 4 women; mean age = 51 ± 3.4 [SD] years; age range, 35–60 years). Images were qualitatively and quantitatively analyzed with respect to imaging presentation. Comparisons were performed using uni- and multivariate analyses.

Results

Regular liver contours had the highest accuracy for the diagnosis of HIV-OP (83%, 35 of 42; 95% confidence interval [CI], 69–93%) and was the most discriminating independent variable for the diagnosis of HIV-OP (odds ratio, 51; 95%CI, 4.96–1272%) (p < 0.0001). At multivariate analysis, the width of segment 4 in millimeters (OR = 1.23 [95%CI, 1.05–1.44%]; p = 0.011) and the presence of regular liver contours (OR = 7.69 [95%CI, 1.48–39.92%]; p = 0.015) were the variables independently associated with the diagnosis of HIV-OP.

Conclusions

Regular liver contours are the most discriminating independent variable for the diagnosis of HIV-OP but have limited accuracy. Familiarity with this finding may help differentiate HIV-OP from cirrhosis in HIV-infected patients.

Key Points

• Regular liver contour is the most discriminating independent variable for the diagnosis of HIV-OP (odds ratio = 51) with 83% accuracy.

• At multivariate analysis, the width of segment 4 in millimeters and the presence of regular liver contours are the variables independently associated with the diagnosis of HIV-OP.

• MRI helps diagnose HIV-OP in the presence of several categorical findings, which are more frequently observed in HIV-OP patients than in HIV patients with cirrhosis.

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Title: Can we differentiate HIV-associated obliterative portopathy from liver cirrhosis using MRI?
Authors: Esther Chouraqui
Laura Leguilloux
Anthony Dohan
Hervé Gouya
Matthias Barral
Anais Vallet-Pichard
Philippe Sogni
Stanislas Pol
Vincent Mallet
Philippe Soyer
Publication date: 01-01-2020
Publisher: Springer Berlin Heidelberg
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Human Immunodeficiency Virus
Liver Cirrhosis
Published in: European Radiology / Issue 1/2020
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-019-06391-6

At a glance: The STEP trials

Springer Medicine

Can we differentiate HIV-associated obliterative portopathy from liver cirrhosis using MRI?

Abstract

Aim

Methods

Results

Conclusions

Key Points

At a glance: The STEP trials

Springer Medicine

Abstract

Aim

Methods

Results

Conclusions

Key Points

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