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European Radiology
Published in: European Radiology 11/2019

Open Access 01-11-2019 | Breast Cancer | Breast

Does three-dimensional functional infrared imaging improve breast cancer detection based on digital mammography in women with dense breasts?

Authors: Roxanna J. Hellgren, Ann E. Sundbom, Kamila Czene, David Izhaky, Per Hall, Paul W. Dickman

Published in: European Radiology | Issue 11/2019

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Abstract

Purpose

We aimed to estimate the incremental cancer detection rate achieved by adding three-dimensional functional infrared imaging (3DIRI) to digital mammography in women with dense breasts.

Materials and methods

In this prospective study conducted between December 2014 and April 2016, 1727 women (median age 56) with percentage volumetric breast density > 6% were recruited at routine screening mammography to undergo additional 3DIRI. The 3DIRI findings were classified as negative or positive. Women with a negative mammography but positive 3DIRI were referred to dynamic contrast-enhanced MRI, whereas all other women underwent routine follow-up based on the mammography finding. Diagnosis of breast cancer was verified by histopathologic examination. The number of women diagnosed with a malignancy formed the basis of our statistical analysis.

Results

Mammography detected 7 cancers in 7 women. Of 1692 women with negative mammography, 222 women (13%) had a positive 3DIRI of which 219 underwent MRI. An additional 6 cancers were identified in 5 women, increasing the diagnostic yield from 7 of 1727 (0.41%) to 12 of 1727 (0.69%). The incremental cancer detection rate associated with using 3DIRI to select women for MRI was 5 of 222 (22.5 additional cancers per 1000).

Conclusion

The use of 3DIRI to select women for an additional MRI can result in the detection of additional cancers in women with dense breasts, but at the expense of additional false positives and considerably lower positive predictive value of the combined examinations. Additional studies are necessary to evaluate the role of 3DIRI as an adjunct to mammography.

Key Points

• Use of three-dimensional functional infrared imaging to select women for an MRI in addition to screening mammography has the potential to improve breast cancer detection in women with dense breasts.
Appendix
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Metadata
Title
Does three-dimensional functional infrared imaging improve breast cancer detection based on digital mammography in women with dense breasts?
Authors
Roxanna J. Hellgren
Ann E. Sundbom
Kamila Czene
David Izhaky
Per Hall
Paul W. Dickman
Publication date
01-11-2019
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 11/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-019-06248-y

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