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European Radiology
Published in: European Radiology 10/2019

01-10-2019 | Stroke | Neuro

Benefit from revascularization after thrombectomy according to FLAIR vascular hyperintensities–DWI mismatch

Authors: Laurence Legrand, Guillaume Turc, Myriam Edjlali, Marine Beaumont, Vincent Gautheron, Wagih Ben Hassen, Sylvain Charron, Denis Trystram, Grégoire Boulouis, Romain Bourcier, Joseph Benzakoun, Olivier Naggara, Frédéric Clarençon, Serge Bracard, Catherine Oppenheim, on behalf of the THRACE Investigators

Published in: European Radiology | Issue 10/2019

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Abstract

Objectives

We tested whether FLAIR vascular hyperintensities (FVH)–DWI mismatch could identify candidates for thrombectomy most likely to benefit from revascularization.

Methods

We retrospectively reviewed 100 patients with proximal MCA occlusion from 18 stroke centers randomized in the IV-thrombolysis plus mechanical thrombectomy arm of the THRACE trial (2010–2015). We tested the associations between successful revascularization on digital subtraction angiography (modified Thrombolysis in Cerebral Infarction 2b/3) and 3-month favorable outcome (modified Rankin Scale score ≤ 2), stratified on FVH–DWI mismatch status, with secondary analyses adjusted on National Institutes of Health Stroke Scale (NIHSS) and DWI lesion volume.

Results

FVH–DWI mismatch was present in 79% of patients, with a similar prevalence at 1.5 T (80%) and 3 T (78%). Successful revascularization (74%) was more frequent in patients with FVH–DWI mismatch (63/79, 80%) than in patients without (11/21, 52%), p = 0.01. The OR of favorable outcome for revascularization were 15.05 (95% CI 3.12–72.61, p < 0.001) in patients with FVH–DWI mismatch and 0.83 (95% CI 0.15–4.64, p = 0.84) in patients without FVH–DWI mismatch (p = 0.011 for interaction). Similar results were observed after adjustment for NIHSS (OR = 12.73 [95% CI 2.69–60.41, p = 0.001] and 0.96 [95% CI 0.15–6.30, p = 0.96]) or for DWI volume (OR = 12.37 [95% CI 2.76–55.44, p = 0.001] and 0.91 [95% CI 0.16–5.33, p = 0.92]) in patients with and without FVH–DWI mismatch, respectively.

Conclusions

The FVH–DWI mismatch identifies patients likeliest to benefit from revascularization, irrespective of initial DWI lesion volume and clinical stroke severity, and could serve as a useful surrogate marker for penumbral evaluation.

Key Points

• The FVH–DWI mismatch, defined by FLAIR vascular hyperintensities (FVH) located beyond the boundaries of the DWI lesion, is associated with large penumbra.
• Among stroke patients with proximal middle cerebral artery occlusion referred for thrombectomy, those with FVH–DWI mismatch are most likely to benefit from revascularization.
• FVH–DWI mismatch provides an alternative to PWI–DWI mismatch in order to select patients who are candidates for thrombectomy.
Appendix
Available only for authorised users
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Metadata
Title
Benefit from revascularization after thrombectomy according to FLAIR vascular hyperintensities–DWI mismatch
Authors
Laurence Legrand
Guillaume Turc
Myriam Edjlali
Marine Beaumont
Vincent Gautheron
Wagih Ben Hassen
Sylvain Charron
Denis Trystram
Grégoire Boulouis
Romain Bourcier
Joseph Benzakoun
Olivier Naggara
Frédéric Clarençon
Serge Bracard
Catherine Oppenheim
on behalf of the THRACE Investigators
Publication date
01-10-2019
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 10/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-019-06094-y

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