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European Radiology
Published in: European Radiology 6/2019

01-06-2019 | Hepatobiliary-Pancreas

CT imaging comparison between intraductal papillary neoplasms of the bile duct and papillary cholangiocarcinomas

Authors: Takahiro Komori, Dai Inoue, Yoh Zen, Norihide Yoneda, Azusa Kitao, Kazuto Kozaka, Akira Yokka, Fumihito Toshima, Takashi Matsubara, Satoshi Kobayashi, Toshifumi Gabata

Published in: European Radiology | Issue 6/2019

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Abstract

Objectives

To identify imaging features that assist in discriminating intraductal papillary neoplasms of the bile duct (IPNBs) from papillary cholangiocarcinomas (PCCs).

Methods

This study was approved by the institutional review board. Using the recently proposed histological diagnostic criteria for biliary papillary neoplasms, IPNBs and PCCs were selected from 537 biliary neoplasms consecutively resected in a 12.5-year period. Clinical and imaging features were compared between the two groups.

Results

The histology review identified 19 IPNBs and 48 PCCs, representing an estimated prevalence of IPNBs among biliary neoplasms of 4%. Approximately one half of IPNBs were incidentally found on imaging conducted for other purposes. In terms of tumor location, 15/19 IPNBs (79%) developed in intrahepatic bile ducts, and 41/48 PCCs (85%) in the distal bile duct. Cystic appearance was highly suggestive for IPNBs (p < 0.001). Using these two parameters, 78% of papillary bile duct neoplasms could be classified into IPNBs or PCCs. Other imaging findings favoring IPNBs included frond-like mural nodule, downstream bile duct dilatation, and the lack of abnormal enhancement in the adjacent bile duct. Interestingly, two patients with non-invasive or microinvasive IPNB had undergone abdominal imaging studies > 3 years before, and a retrospective review of the previous images identified small nodular or cystic lesions, suggesting a less progressive nature of IPNBs than currently thought.

Conclusions

Imaging findings useful for discriminating IPNBs from PCCs appear to be tumor location, shape of tumor, appearance of mural nodules, duct dilatation at unaffected duct, and abnormal enhancement of the adjacent bile duct.

Key Points

• Intrahepatic location and cystic dilatation of the affected bile duct are the strong discriminators between IPNBs and PCCs.
• The shape of the mural nodule and appearance of the neighboring bile duct are helpful for distinguishing IPNBs and PCCs.
• The less aggressive behavior of IPNBs compared with PCCs may facilitate less invasive management in patients with IPNB.
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Metadata
Title
CT imaging comparison between intraductal papillary neoplasms of the bile duct and papillary cholangiocarcinomas
Authors
Takahiro Komori
Dai Inoue
Yoh Zen
Norihide Yoneda
Azusa Kitao
Kazuto Kozaka
Akira Yokka
Fumihito Toshima
Takashi Matsubara
Satoshi Kobayashi
Toshifumi Gabata
Publication date
01-06-2019
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 6/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-018-5841-0

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