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01-06-2019 | Bile Duct Cancer | Editorial Comment

Differentiation of two subtypes of intrahepatic cholangiocarcinoma: imaging approach

Author: Kengo Yoshimitsu

Published in: European Radiology | Issue 6/2019

Key Points

• Mass-forming intrahepatic cholangiocarcinoma can be divided into two subgroups, namley, perihilar and peripheral types.

• These two significantly differ in clinico-biological behaviors, and in patients’ prognosis as well.

• This differentiation may be achieved solely by contrast-enhanced MR imaging findings.

Aishima S, Kuroda Y, Nishihara Y et al (2007) Proposal of progression model for intrahepatic cholangiocarcinoma: clinicopathologic differences between hilar type and peripheral type. Am J Surg Pathol 31:1059–1067CrossRefPubMed

Nakanuma Y, Sato Y, Harada K et al (2010) Pathological classification of intrahepatic cholangiocarcinoma based on a new concept. World J Hepatol 2:419–427CrossRefPubMedCentralPubMed

Komuta M, Govaere O, Vandecaveye V et al (2012) Histological diversity in cholangiocellular carcinoma reflects the different cholangiocyte phenotypes. Hepatology 55:1876–1888CrossRefPubMed

Aishima S, Fujita N, Mano Y et al (2010) p62+ Hyaline inclusions in intrahepatic cholangiocarcinoma associated with viral hepatitis or alcoholic liver disease. Am J Clin Pathol 134:457–465CrossRefPubMed

Fan B, Malato Y, Calvisi DF et al (2012) Cholangiocarcinomas can originate from hepatocytes in mice. J Clin lnvest 122:2911–2915CrossRef

Aishima S, Fujita N, Mano Y et al (2011) Different roles of SIOOP overexpression in intrahepatic cholangiocarcinoma : carcinogenesis of perihilar type and aggressive behavior of peripheral type. Am J Surg Pathol 35:590–598CrossRefPubMed

Nishihara Y, Aishima S, Hayashi A et al (2009) CDIO+ fibroblasts are more involved in the progression of hilar/extrahepatic cholangiocarcinoma than of peripheral intrahepatic cholangiocarcinoma. Histopathology 55:423–431CrossRefPubMed

Yu TH, Yuan RH, Chen YL et al (2011) Viral hepatitis is associated with intrahepatic cholangiocarcinoma with cholangiolar differentiation and N-cadherin expression. Mod Pathol 24:810–819CrossRefPubMed

Carpino G, Cardinale V, Onori P et al (2012) Biliary tree stem/progenitor cells in glands of extrahepatic and intrahepatic bile ducts: an anatomical in situ study yielding evidence of maturational lineages. J Anat 220:186–199CrossRefPubMed

10.

Rhee H, Kim MJ, Park YN, An C (2019) A proposal of imaging classification of intrahepatic mass-forming cholangiocarcinoma into ductal and parenchymal types: clinicopathologic significance. Eur Radiol. https://doi.org/10.1007/s00330-018-5898-9

Title: Differentiation of two subtypes of intrahepatic cholangiocarcinoma: imaging approach
Author: Kengo Yoshimitsu
Publication date: 01-06-2019
Publisher: Springer Berlin Heidelberg
Keywords: Bile Duct Cancer
Cholangiocarcinoma
Bile Duct Cancer
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Cholangiocarcinoma
Published in: European Radiology / Issue 6/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-019-06135-6

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Differentiation of two subtypes of intrahepatic cholangiocarcinoma: imaging approach

Key Points

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Key Points

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