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European Radiology
Published in: European Radiology 3/2019

01-03-2019 | Gastrointestinal

Characteristics and associated risk factors of diverticular disease assessed by magnetic resonance imaging in subjects from a Western general population

Authors: Corinna Storz, Theresa Rothenbacher, Susanne Rospleszcz, Jakob Linseisen, Helmut Messmann, Carlo N. De Cecco, Jürgen Machann, Roberto Lorbeer, Lena S. Kiefer, Elke Wintermeyer, Sophia D. Rado, Konstantin Nikolaou, Stefanie Elser, Wolfgang Rathmann, Maximilian F. Reiser, Annette Peters, Christopher L. Schlett, Fabian Bamberg

Published in: European Radiology | Issue 3/2019

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Abstract

Objectives

Diverticular disease represents an increasing pathology and healthcare burden worldwide. Our aim was to study the prevalence, extent and distribution of asymptomatic diverticular disease assessed by magnetic resonance imaging (MRI) in a sample of a Western population.

Methods

Subjects from a population-based cohort study who underwent 3-T MRI were analyzed for the prevalence and extent of diverticula of the colon using an isotropic VIBE-Dixon gradient-echo sequence. The extent of diverticular disease was categorized according to the number of diverticula in each colonic segment. Univariate and adjusted analyses were performed to assess associated characteristics and risk factors.

Results

Among 393 subjects included in the analysis (56.4 ± 9.2 years, 57.5% males), 164 (42%) had diverticular disease, with the highest prevalence in the left-sided colonic segments (93% diverticular disease in the descending and sigmoid segment). Subjects with advanced diverticular disease were older (62.1 vs. 54.4 years) and had a higher body mass index (BMI), LDL cholesterol levels and systolic blood pressure (30.2 ± 5.1 vs. 27.8 ± 4.9 kg/m2, 149.8 ± 29.3 vs. 135.2 ± 32.9 mg/dl and 128.2 ± 14.1 vs. 118.4 ± 16.1 mmHg, respectively; all p > 0.003) compared with subjects without diverticular disease. In contrast, no significant correlation could be found for gender, physical activity, smoking status and alcohol consumption (all p > 0.31). Intra-rater reliability was excellent for all colonic segments (intra-class correlation [ICC] = 0.99-1.00), and inter-rater reliability was excellent for left- and right-sided colonic segments (ICC = 0.84-0.97).

Conclusions

These findings provide insights into the disease mechanism of asymptomatic diverticular disease and may help to improve prevention of diverticulosis and its associated complications.

Key Points

• Overall prevalence of asymptomatic diverticular disease assessed by MRI was 42%, affecting predominantly the left-sided colon.
• Asymptomatic diverticular disease was associated with age and cardiometabolic risk factors.
• Magnetic resonance imaging reveals insights into the pathophysiologic mechanism of asymptomatic diverticular disease.
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Metadata
Title
Characteristics and associated risk factors of diverticular disease assessed by magnetic resonance imaging in subjects from a Western general population
Authors
Corinna Storz
Theresa Rothenbacher
Susanne Rospleszcz
Jakob Linseisen
Helmut Messmann
Carlo N. De Cecco
Jürgen Machann
Roberto Lorbeer
Lena S. Kiefer
Elke Wintermeyer
Sophia D. Rado
Konstantin Nikolaou
Stefanie Elser
Wolfgang Rathmann
Maximilian F. Reiser
Annette Peters
Christopher L. Schlett
Fabian Bamberg
Publication date
01-03-2019
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 3/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-018-5687-5

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