Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
European Radiology
Published in: European Radiology 3/2019

01-03-2019 | Head and Neck

Early white matter injuries associated with dopamine transporter dysfunction in patients with acute CO intoxication: A diffusion kurtosis imaging and Tc-99m TRODAT-1 SPECT study

Authors: Ming-Chung Chou, Ping-Hong Lai, Jie-Yuan Li

Published in: European Radiology | Issue 3/2019

Login to get access

Abstract

Purpose

Patients with CO intoxication were demonstrated to exhibit white matter (WM) injuries, changes in substantia nigra, dopamine transporter dysfunctions of striatum and Parkinsonism symptoms. We aimed to investigate the relationship between WM injuries of dopaminergic pathways and dopamine transporter dysfunctions of the striatum in patients with acute CO intoxication using both diffusion kurtosis imaging (DKI) and single photon-emission computed tomography (SPECT).

Materials and methods

Seventeen patients with acute CO intoxication and 19 age- and gender-matched healthy subjects were enrolled. DKI data were acquired from all participants and Tc-99m-TRODAT-1 SPECT scan was performed on each patient. DKI datasets were fitted to obtain axial, radial and mean diffusivity, fractional anisotropy, axial, radial and mean kurtosis for voxel-based comparison. In addition, the TRODAT-1 binding ratio of the striatum was calculated using the occipital cortices as a reference. In significant regions, correlational analysis was performed to understand the relationship between DKI indices and TRODAT-1 binding ratio.

Results

The results showed that DKI indices were significantly altered in multiple WM regions broadly involving the basal ganglia-thalamocortical circuit and nigrostriatal pathway. The correlation analysis further revealed significant correlations between DKI indices and the TRODAT-1 binding ratio in the nigrostriatal pathway (absolute correlation coefficients ranged from 0.5992 to 0.6950, p<0.05), suggesting that CO-induced early WM injuries were associated with dopamine transporter dysfunctions of striatum.

Conclusion

We concluded that DKI and Tc-99m-TRODAT-1 SPECT scans were helpful in early detection of global WM injuries associated with dysfunctions of dopamine transporter in patients with acute CO intoxication.

Key Points

• Voxel-based diffusion kurtosis imaging analysis was helpful in globally detecting early white matter injuries in patients with acute CO intoxication.
• CO-induced early white matter injuries were broadly located in basal ganglia-thalamocortical circuit and nigrostriatal pathway.
• Early white matter injuries in dopaminergic pathways were significantly correlated with dopamine transporter dysfunctions of the striatum.
Appendix
Available only for authorised users
Literature
1.
Gale SD, Hopkins RO, Weaver LK, Bigler ED, Booth EJ, Blatter DD (1999) MRI, quantitative MRI, SPECT, and neuropsychological findings following carbon monoxide poisoning. Brain Inj 13:229–243CrossRefPubMed
2.
Prockop LD (2005) Carbon monoxide brain toxicity: Clinical, magnetic resonance imaging, magnetic resonance spectroscopy, and neuropsychological effects in 9 people. J Neuroimaging 15:144–149CrossRefPubMed
3.
Weaver LK, Hopkins RO, Chan KJ et al (2002) Hyperbaric oxygen for acute carbon monoxide poisoning. N Engl J Med 347:1057–1067CrossRefPubMed
4.
Chiew AL, Buckley NA (2014) Carbon monoxide poisoning in the 21st century. Crit Care (2014) 18:221
5.
Neil J, Miller J, Mukherjee P, Hüppi PS (2002) Diffusion tensor imaging of normal and injured developing human brain - a technical review. NMR Biomed 15:543–552CrossRefPubMed
6.
Chang CC, Chang WN, Lui CC et al (2011) Clinical significance of the pallidoreticular pathway in patients with carbon monoxide intoxication. Brain 134:3632–3646CrossRefPubMed
7.
Chang CC, Chang WN, Lui CC et al (2010) Longitudinal study of carbon monoxide intoxication by diffusion tensor imaging with neurospsychiatric correlation. J Psychiatry Neurosci 35:115–125CrossRefPubMedPubMedCentral
8.
Lin WC, Lu CH, Lee YC et al (2009) White Matter Damage in Carbon Monoxide Intoxication Assessed in Vivo Using Diffusion Tensor MR Imaging. AJNR Am J Neuroradiol 30:1248–1255CrossRefPubMedPubMedCentral
9.
Chang CC, Lee YC, Chang WN et al (2009) Damage of White Matter Tract Correlated with Neuropsychological Deficits in Carbon Monoxide Intoxication after Hyperbaric Oxygen Therapy. J Neurotrauma 26:1263–1270CrossRefPubMed
10.
Arab A, Wojna-Pelczar A, Khairnar A, Szabó N, Ruda-Kucerova J (2018) Principles of diffusion kurtosis imaging and its role in early diagnosis of neurodegenerative disorders. Brain Res Bull 139:91–98CrossRefPubMed
11.
Tsai PH, Chou MC, Chiang SW et al (2017) Early white matter injuries in patients with acute carbon monoxide intoxication A tract-specific diffusion kurtosis imaging study and STROBE compliant article. Medicine (Baltimore) 96
12.
Kinoshita T, Sugihara S, Matsusue E, Fujii S, Ametani M, Ogawa T (2005) Pallidoreticular damage in acute carbon monoxide poisoning: Diffusion-weighted MR imaging findings. AJNR Am J Neuroradiol 26:1845–1848PubMedPubMedCentral
13.
O'Donnell P, Buxton PJ, Pitkin A, Jarvis LJ (2000) The magnetic resonance imaging appearances of the brain in acute carbon monoxide poisoning. Clin Radiol 55:273–280CrossRefPubMed
14.
Kao HW, Cho NY, Hsueh CJ et al (2012) Delayed Parkinsonism after CO Intoxication: Evaluation of the Substantia Nigra with Inversion-Recovery MR Imaging. Radiology 265:215–221CrossRefPubMed
15.
Huang WS, Lin SZ, Lin JC, Wey SP, Ting G, Liu RS (2001) Evaluation of early-stage Parkinson's disease with Tc-99m-TRODAT-1 imaging. J Nucl Med 42:1303–1308PubMed
16.
Jenkinson M, Bannister P, Brady M, Smith S (2002) Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 17:825–841CrossRefPubMed
17.
Smith SM (2002) Fast robust automated brain extraction. Hum Brain Map 17:143–155CrossRef
18.
Mori S, Oishi K, Jiang H et al (2008) Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template. Neuroimage 40:570–582CrossRefPubMed
19.
Vercauteren T, Pennec X, Perchant A, Ayache N (2009) Diffeomorphic demons: Efficient non-parametric image registration. Neuroimage 45:S61–S72CrossRefPubMed
20.
Beppu T, Fujiwara S, Nishimoto H et al (2012) Fractional anisotropy in the centrum semiovale as a quantitative indicator of cerebral white matter damage in the subacute phase in patients with carbon monoxide poisoning: correlation with the concentration of myelin basic protein in cerebrospinal fluid. J Neurol 259:1698–1705CrossRefPubMedPubMedCentral
21.
Hou X, Ma L, Wu L et al (2013) Diffusion Tensor Imaging for Predicting the Clinical Outcome of Delayed Encephalopathy of Acute Carbon Monoxide Poisoning. Eur Neurol 69:275–280CrossRefPubMed
22.
Lo CP, Chen SY, Chou MC et al (2007) Diffusion-tensor MR imaging for evaluation of the efficacy of hyperbaric oxygen therapy in patients with delayed neuropsychiatric syndrome caused by carbon monoxide inhalation. Eur J Neurol 14:777–782CrossRefPubMed
23.
24.
Song SK, Yoshino J, Le TQ et al (2005) Demyelination increases radial diffusivity in corpus callosum of mouse brain. Neuroimage 26:132–140CrossRefPubMed
25.
Wheeler-Kingshott CA, Cercignani M (2009) About "Axial" and "Radial" Diffusivities. Magn Reson Med 61:1255–1260CrossRefPubMed
26.
Thom SR (1990) Carbon Monoxide-Mediated Brain Lipid-Peroxidation in the Rat. J Appl Physiol 68:997–1003CrossRefPubMed
27.
Thom SR, Bhopale VM, Han ST, Clark JM, Hardy KR (2006) Intravascular neutrophil activation due to carbon monoxide poisoning. Am J Respir Crit Care Med 174:1239–1248CrossRefPubMedPubMedCentral
28.
Chou MC, Ko CW, Chiu YH, Chung HW, Lai PH (2017) Effects of B Value on Quantification of Rapid Diffusion Kurtosis Imaging in Normal and Acute Ischemic Brain Tissues. J Comput Assist Tomogr 41:868–876CrossRefPubMed
29.
Yan X, Zhou MX, Ying LF et al (2013) Evaluation of optimized b-value sampling schemas for diffusion kurtosis imaging with an application to stroke patient data. Comput Med Imaging Graph 37:272–280CrossRefPubMedPubMedCentral
30.
Metadata
Title
Early white matter injuries associated with dopamine transporter dysfunction in patients with acute CO intoxication: A diffusion kurtosis imaging and Tc-99m TRODAT-1 SPECT study
Authors
Ming-Chung Chou
Ping-Hong Lai
Jie-Yuan Li
Publication date
01-03-2019
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 3/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-018-5673-y

Other articles of this Issue 3/2019

European Radiology 3/2019 Go to the issue

Gastrointestinal

Characteristics and associated risk factors of diverticular disease assessed by magnetic resonance imaging in subjects from a Western general population

Chest

Implication of total tumor size on the prognosis of patients with clinical stage IA lung adenocarcinomas appearing as part-solid nodules: Does only the solid portion size matter?

Oncology

Hepatocellular carcinoma: CT texture analysis as a predictor of survival after surgical resection

Cardiac

Cardiac magnetic resonance in patients with mitral valve prolapse: Focus on late gadolinium enhancement and T1 mapping

Ultrasound

Role of second high-intensity focused ultrasound (HIFU) treatment for unsatisfactory benign thyroid nodules after first treatment

Neuro

Significance of hyperintense arteries on Gd-enhanced 3D T1W black-blood imaging in acute stroke