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Open Access 01-12-2018 | Cardiac

Biatrial performance in children with hypertrophic cardiomyopathy: CMR study

Authors: Łukasz Mazurkiewicz, Lidia Ziółkowska, Joanna Petryka, Mateusz Śpiewak, Łukasz Małek, Agata Kubik, Magdalena Marczak, Jolanta Misko, Grażyna Brzezińska-Rajszys

Published in: European Radiology | Issue 12/2018

Abstract

Objectives

To investigate biatrial mechanics and their relation with left ventricular outflow tract (LVOT) obstruction (LVOTO), the degree of hypertrophy, indices of ventricular diastolic function and fibrosis in children with hypertrophic cardiomyopathy (HCM).

Methods

Fifty-five consecutive, prospectively recruited children with HCM (mean age 12.5 ± 4.6 years, 69.1% male), 19 (34.5%) of whom had LVOTO, underwent cardiac magnetic resonance and echocardiography with quantification of phasic components of biatrial function, biventricular diastolic function and fibrosis. Twenty healthy, sex-matched subjects served as controls.

Results

We found a significant increase of left atrial (LA) and right atrial (RA) volumes and reduction in the majority of indices of contractile function, strains and strain rates (p < 0.05) in children with HCM compared with controls. Nearly all of the LA dynamics markers attained a significant association with the LVOT gradient (p < 0.05), the RA volumes and contractile functions were affected by LV fibrosis and mass (p < 0.05), and the RA mechanical components were related to the degree of LVOTO (p < 0.05). The minority of biatrial dynamics markers were associated with indices of ventricular diastolic function.

Conclusions

The majority of biatrial volumetric and functional indices were severely compromised in children with HCM compared with controls. The degree of LVOTO appears to trigger LA volumetric and LA and RA mechanical malfunction. On the other hand, the deterioration of RA volumetric components was linked to LV fibrosis and mass.

Key Points

• Biatrial function was severely compromised in children with HCM.

• Left atrial malfunction was associated with the degree of LVOTO.

• Fibrosis and LV mass were related to RA volumetric and contractile dysfunction.

• The degree of LVOTO was linked to right atrial mechanical abnormalities.

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Title: Biatrial performance in children with hypertrophic cardiomyopathy: CMR study
Authors: Łukasz Mazurkiewicz
Lidia Ziółkowska
Joanna Petryka
Mateusz Śpiewak
Łukasz Małek
Agata Kubik
Magdalena Marczak
Jolanta Misko
Grażyna Brzezińska-Rajszys
Publication date: 01-12-2018
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 12/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5519-7

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Biatrial performance in children with hypertrophic cardiomyopathy: CMR study

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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