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European Radiology
Published in: European Radiology 11/2018

01-11-2018 | Magnetic Resonance

Quantitative MR spectroscopy reveals metabolic changes in the dorsolateral prefrontal cortex of patients with temporal lobe epilepsy

Authors: Qiaoyue Tan, Huaiqiang Sun, Weina Wang, Xintong Wu, Nanya Hao, Xiaorui Su, Xibiao Yang, Simin Zhang, Jingkai Su, Qiang Yue, Qiyong Gong

Published in: European Radiology | Issue 11/2018

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Abstract

Objective

To characterize possible metabolic changes of the dorsolateral prefrontal cortex (DLPFC) in patients with temporal lobe epilepsy (TLE).

Methods

Quantitative proton magnetic resonance spectroscopy (1H-MRS) studies were performed on 24 TLE patients and 22 healthy controls. Metabolite concentrations were calculated using a linear combination model (LCModel) and corrected for cerebrospinal fluid contamination. Comparisons were performed between the TLE patients and the controls and between the left DLPFC and right DLPFC in each group. Pearson correlation coefficients were calculated between the metabolite concentrations and epilepsy duration and between the metabolite concentrations and voxel tissue composition: [gray matter (GM)/(GM+white matter (WM))].

Results

Metabolic asymmetry was found in controls between the left and right DLPFC, i.e., the NAA concentration of the left DLPFC was significantly higher than that of the right. However, such metabolic asymmetry was not observed in TLE patients. Compared with the controls, TLE patients showed significantly decreased NAA and Ins, and the reductions were greater in the left DLPFC. No significant correlation was found between the metabolite concentrations and epilepsy duration or between the metabolite concentrations and voxel tissue composition [GM/(GM+WM)].

Conclusions

This study suggests that TLE can produce metabolic changes to DLPFC that is remote from the seizure focus.

Key Points

• Magnetic resonance spectroscopy probes the brain metabolism noninvasively.
• Dorsolateral prefrontal reductions in NAA (a neuronal marker) and Ins are observed in TLE.
• Temporal lobe epilepsy can result in metabolic changes remote from the seizure focus.
Literature
1.
Sidek S, Ramli N (2016) In vivo proton magnetic resonance spectroscopy (1H- MRS) evaluation of the metabolite concentration of optic radiation in primary open angle glaucoma. Eur Radiol 26(12):4404–4412CrossRef
2.
Ranjeva JP, Confort-Gouny S, Le Fur Y et al (2000) Magnetic resonance spectroscopy of brain in epilepsy. Childs Nerv Syst 16(4):235–241CrossRef
3.
Lu JJ, Ren LK, Feng F et al (2006) Metabolic abnormalities in mesial temporal lobe epilepsy patients depicted by proton MR spectroscopy using a 3. 0t MR scanner. Chin Med Sci J 21(4):209–213PubMed
4.
Aydin H, Oktay NA, Kizilgoz V, Altin E, Tatar IG, Hekimoglu B (2012) Value of proton-MR-spectroscopy in the diagnosis of temporal lobe epilepsy; correlation of metabolite alterations with electroencephalography. Iran J Radiol 9(1):1–11CrossRef
5.
Li LM, Dubeau F, Andermann F, Arnold DL (2000) Proton magnetic resonance spectroscopic imaging studies in patients with newly diagnosed partial epilepsy. Epilepsia 41(7):825–831CrossRef
6.
Krsek P, Hajek M, Dezortova M et al (2007) 1H MR spectroscopic imaging in patients with MRI-negative extratemporal epilepsy: correlation with ictal onset zone and histopathology. Eur Radiol 17(8):2126–2135CrossRef
7.
Lieb JP, Dasheiff RM, Engel J Jr (1991) Role of the frontal lobes in the propagation of mesial temporal lobe seizures. Epilepsia 32(6):822–837CrossRef
8.
Drake M, Allegri RF, Thomson A (2000) Executive cognitive alteration of prefrontal type in patients with mesial temporal lobe epilepsy. Medicina (B Aires) 60(4):453–456
9.
Hermann B, Seidenberg M, Lee EJ, Chan F, Rutecki P (2007) Cognitive phenotypes in temporal lobe epilepsy. J Int Neuropsychol Soc 13(1):12–20CrossRef
10.
Paik E (1998) Functions of the prefrontal cortex in the human brain. J Korean Med Sci 13(6):569–581CrossRef
11.
Provencher SW (2001) Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed 14(4):260–264CrossRef
12.
Provencher SW (1993) Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 30(6):672–679CrossRef
13.
Hammen T, Hildebrandt M, Stadlbauer A et al (2008) Non-invasive detection of hippocampal sclerosis: correlation between metabolite alterations detected by (1)H-MRS and neuropathology. NMR Biomed 21(6):545–552CrossRef
14.
Yue Q, Liu M, Nie X et al (2012) Quantitative 3.0T MR spectroscopy reveals decreased creatine concentration in the dorsolateral prefrontal cortex of patients with social anxiety disorder. PLoS One 7(10):e48105CrossRef
15.
Woermann FG, McLean MA, Bartlett PA, Parker GJ, Barker GJ, Duncan JS (1999) Short echo time single-voxel 1H magnetic resonance spectroscopy in magnetic resonance imaging-negative temporal lobe epilepsy: different biochemical profile compared with hippocampal sclerosis. Ann Neurol 45(3):369–376CrossRef
16.
Petroff OA, Errante LD, Kim JH, Spencer DD (2003) N-acetyl-aspartate, total creatine, and myo-inositol in the epileptogenic human hippocampus. Neurology 60(10):1646–1651CrossRef
17.
Bernard D, Walker PM, Baudouin-Poisson N et al (1996) Asymmetric metabolic profile in mesial temporal lobes: localized H-1 MR spectroscopy in healthy right-handed and non-right-handed subjects. Radiology 199(2):381–389CrossRef
18.
Riederer F, Bittsansky M, Schmidt C et al (2006) 1H magnetic resonance spectroscopy at 3 T in cryptogenic and mesial temporal lobe epilepsy. NMR Biomed 19(5):544–553CrossRef
19.
Jayasundar R (2002) Human brain: biochemical lateralization in normal subjects. Neurol India 50(3):267–271PubMed
20.
Rademacher J, Burgel U, Geyer S et al (2001) Variability and asymmetry in the human precentral motor system. A cytoarchitectonic and myeloarchitectonic brain mapping study. Brain 124(Pt 11):2232–2258CrossRef
21.
Amunts K, Schlaug G, Schleicher A et al (1996) Asymmetry in the human motor cortex and handedness. Neuroimage 4(3 Pt 1):216–222CrossRef
22.
Gur RC, Packer IK, Hungerbuhler JP et al (1980) Differences in the distribution of gray and white matter in human cerebral hemispheres. Science 207(4436):1226–1228CrossRef
23.
Wellard RM, Briellmann RS, Prichard JW, Syngeniotis A, Jackson GD (2003) Myoinositol abnormalities in temporal lobe epilepsy. Epilepsia 44(6):815–821CrossRef
24.
Capizzano AA, Vermathen P, Laxer KD et al (2002) Multisection proton MR spectroscopy for mesial temporal lobe epilepsy. AJNR Am J Neuroradiol 23(8):1359–1368PubMedPubMedCentral
25.
Mueller SG, Laxer KD, Cashdollar N, Flenniken DL, Matson GB, Weiner MW (2004) Identification of abnormal neuronal metabolism outside the seizure focus in temporal lobe epilepsy. Epilepsia 45(4):355–366CrossRef
26.
Mueller SG, Ebel A, Barakos J et al (2011) Widespread extrahippocampal NAA/(Cr+Cho) abnormalities in TLE with and without mesial temporal sclerosis. J Neurol 258(4):603–612CrossRef
27.
Vermathen P, Laxer KD, Schuff N, Matson GB, Weiner MW (2003) Evidence of neuronal injury outside the medial temporal lobe in temporal lobe epilepsy: N-acetylaspartate concentration reductions detected with multisection proton MR spectroscopic imaging--initial experience. Radiology 226(1):195–202CrossRef
28.
Fisher SK, Novak JE, Agranoff BW (2002) Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance. J Neurochem 82(4):736–754CrossRef
29.
Brand A, Leibfritz D, Richter-Landsberg C (1999) Oxidative stress-induced metabolic alterations in rat brain astrocytes studied by multinuclear NMR spectroscopy. J Neurosci Res 58(4):576–585CrossRef
30.
Flugel D, McLean MA, Simister RJ, Duncan JS (2006) Magnetisation transfer ratio of choline is reduced following epileptic seizures. NMR Biomed 19(2):217–222CrossRef
31.
Lunsing RJ, Strating K, de Koning TJ, Sijens PE (2017) Diagnostic value of MRS-quantified brain tissue lactate level in identifying children with mitochondrial disorders. Eur Radiol 27(3):976–984CrossRef
32.
Petroff OA, Pleban LA, Spencer DD (1995) Symbiosis between in vivo and in vitro NMR spectroscopy: the creatine, N-acetylaspartate, glutamate, and GABA content of the epileptic human brain. Magn Reson Imaging 13(8):1197–1211CrossRef
33.
Olsen RW, Avoli M (1997) GABA and epileptogenesis. Epilepsia 38(4):399–407CrossRef
34.
Sherwin A, Robitaille Y, Quesney F et al (1988) Excitatory amino acids are elevated in human epileptic cerebral cortex. Neurology 38(6):920–923CrossRef
35.
Westman E, Spenger C, Wahlund LO, Lavebratt C (2007) Carbamazepine treatment recovered low N-acetylaspartate+N-acetylaspartylglutamate (tNAA) levels in the megencephaly mouse BALB/cByJ-Kv1.1(mceph/mceph). Neurobiol Dis 26(1):221–228CrossRef
36.
Campos BA, Yasuda CL, Castellano G, Bilevicius E, Li LM, Cendes F (2010) Proton MRS may predict AED response in patients with TLE. Epilepsia 51(5):783–788CrossRef
Metadata
Title
Quantitative MR spectroscopy reveals metabolic changes in the dorsolateral prefrontal cortex of patients with temporal lobe epilepsy
Authors
Qiaoyue Tan
Huaiqiang Sun
Weina Wang
Xintong Wu
Nanya Hao
Xiaorui Su
Xibiao Yang
Simin Zhang
Jingkai Su
Qiang Yue
Qiyong Gong
Publication date
01-11-2018
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 11/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-018-5443-x

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