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01-10-2018 | Magnetic Resonance

Accurate IVIM model-based liver lesion characterisation can be achieved with only three b-value DWI

Authors: P. Mürtz, A. M. Sprinkart, M. Reick, C. C. Pieper, A.-H. Schievelkamp, R. König, H. H. Schild, W. A. Willinek, G. M. Kukuk

Published in: European Radiology | Issue 10/2018

Abstract

Objective

The objective of this study was to evaluate a simplified intravoxel incoherent motion (IVIM) approach of diffusion-weighted imaging (DWI) with four b-values for liver lesion characterisation at 1.5 T.

Methods

DWI data from a respiratory-gated MRI sequence with b = 0, 50, 250, 800 s/mm² were retrospectively analysed in 173 lesions and 40 healthy livers. The apparent diffusion coefficient ADC = ADC(0,800) and IVIM-based parameters D₁′ = ADC(50,800), D₂′ =ADC(250,800), f₁′, f₂′, D*′, ADC_low = ADC(0,50), and ADC_diff=ADC_low-D₂′ were calculated voxel-wise without fitting procedures. Differences between lesion groups were investigated.

Results

Focal nodular hyperplasias were best discriminated from all other lesions by f₁′ with an area under the curve (AUC) of 0.989. Haemangiomas were best discriminated by D₁′ (AUC of 0.994). For discrimination between malignant and benign lesions, ADC(0,800) and D₁′ were best suited (AUC of 0.915 and 0.858, respectively). Discriminatory power was further increased by using a combination of D₁′ and f₁′.

Conclusion

IVIM parameters D and f approximated from three b-values provided more discriminatory power between liver lesions than ADC determined from two b-values. The use of b = 0, 50, 800 s/mm² was superior to that of b = 0, 250, 800 s/mm². The acquisition of four instead of three b-values has no further benefit for lesion characterisation.

Key Points

• Diffusion and perfusion characteristics are assessable with only three b-values.

• Association of b = 0, 50, 800 s/mm²is superior to b = 0, 250, 800 s/mm².

• A fourth acquired b-value has no benefit for differential diagnosis.

• For liver lesion characterisation, simplified IVIM analysis is superior to ADC determination.

• Simplified IVIM approach guarantees numerically stable, voxel-wise results and short acquisition times.

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Title: Accurate IVIM model-based liver lesion characterisation can be achieved with only three b-value DWI
Authors: P. Mürtz
A. M. Sprinkart
M. Reick
C. C. Pieper
A.-H. Schievelkamp
R. König
H. H. Schild
W. A. Willinek
G. M. Kukuk
Publication date: 01-10-2018
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 10/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5401-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Accurate IVIM model-based liver lesion characterisation can be achieved with only three b-value DWI

Abstract

Objective

Methods

Results

Conclusion

Key Points

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

Key Points

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