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European Radiology
Published in: European Radiology 2/2013

01-02-2013 | Magnetic Resonance

Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases

Authors: A. Andreou, D. M. Koh, D. J. Collins, M. Blackledge, T. Wallace, M. O. Leach, M. R. Orton

Published in: European Radiology | Issue 2/2013

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Abstract

Objective

To determine the measurement reproducibility of perfusion fraction f, pseudodiffusion coefficient D * and diffusion coefficient D in colorectal liver metastases and normal liver.

Methods

Fourteen patients with known colorectal liver metastases were examined twice using respiratory-triggered echo-planar DW-MRI with eight b values (0 to 900 s/mm2) 1 h apart. Regions of interests were drawn around target metastasis and normal liver in each patient to derive ADC (all b values), ADChigh (b values ≥100 s/mm2) and intravoxel incoherent motion (IVIM) parameters f, D * and D by least squares data fitting. Short-term measurement reproducibility of median ADC, ADChigh, f, D * and D values were derived from Bland–Altman analysis.

Results

The measurement reproducibility for ADC, ADChigh and D was worst in colorectal liver metastases (−21 % to +25 %) compared with liver parenchyma (−6 % to +8 %). Poor measurement reproducibility was observed for the perfusion-sensitive parameters of f (−75 % to +241 %) and D * (−89 % to +2,120 %) in metastases, and to a lesser extent the f (−24 % to +25 %) and D* (−31 % to +59 %) of liver.

Conclusions

Estimates of f and D * derived from the widely used least squares IVIM fitting showed poor measurement reproducibility. Efforts should be made to improve the measurement reproducibility of perfusion-sensitive IVIM parameters.

Key Points

• Quantitative diffusion-weighted MRI parameters are increasingly used for clinical management decisions.
• However perfusion-sensitive intravoxel incoherent motion (IVIM) parameters showed poor measurement reproducibility.
• Measurement reproducibility of IVIM parameters was worse in metastases than normal liver.
• Efforts to improve measurement reproducibility of IVIM parameters should be explored.
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Metadata
Title
Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases
Authors
A. Andreou
D. M. Koh
D. J. Collins
M. Blackledge
T. Wallace
M. O. Leach
M. R. Orton
Publication date
01-02-2013
Publisher
Springer-Verlag
Published in
European Radiology / Issue 2/2013
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-012-2604-1

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