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European Radiology
Published in: European Radiology 7/2018

01-07-2018 | Gastrointestinal

Could IVIM and ADC help in predicting the KRAS status in patients with rectal cancer?

Authors: Yanyan Xu, Qiaoyu Xu, Hongliang Sun, Tongxi Liu, Kaining Shi, Wu Wang

Published in: European Radiology | Issue 7/2018

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Abstract

Purpose

To evaluate the diagnostic potential of DW-MRI relative parameters for differentiation of rectal cancers with different Kirsten rat sarcoma viral oncogene homologue (KRAS) mutation status.

Methods

Fifty-one patients with rectal cancer underwent diffusion-weighted MR imaging with eight b values. ADCs (including Max-ADC, Min-ADC and Mean-ADC) and IVIM parameters (D, pure diffusion; f, perfusion fraction; D*, pseudodiffusion coefficient) were respectively calculated by mono- and bi-exponential analysis. Patients were stratified into two groups: KRAS wild type and mutant. The DW-MRI-derived parameters between the KRAS wild-type group and KRAS mutant group were compared using the Mann-Whitney U test. Receiver-operating characteristic (ROC) analysis of discrimination between KRAS wild-type and KRAS mutant rectal cancer was performed for the DW-MRI-derived parameters.

Results

Max-ADC, Mean-ADC and D values were significantly lower in the KRAS mutant group than in the KRAS wild-type group, whereas a higher D* value was demonstrated in the KRAS mutant group. According to the ROC curve, Mean-ADC and D* values showed moderate diagnostic significance with the AUC values of 0.756 and 0.710, respectively. The cut-off values for Mean-ADC and D* were 1.43 × 10-3mm2/s and 26.58 × 10-3mm2/s, respectively.

Conclusion

Rectal cancers had distinctive diffusion/perfusion characteristics in different KRAS mutation statuses. The DW-MRI-derived parameters, specifically Mean-ADC and D*, show a moderate diagnostic significance for KRAS status.

Key Points

• Rectal cancers with different KRAS mutation statuses demonstrated distinctive diffusion/perfusion characteristics.
• Max-ADC, Mean-ADC and D values were lower in the KRAS mutant group.
• A higher D* value was demonstrated in the KRAS mutant group.
• IVIM-DW MRI may potentially help preoperative KRAS mutant status prediction.
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Metadata
Title
Could IVIM and ADC help in predicting the KRAS status in patients with rectal cancer?
Authors
Yanyan Xu
Qiaoyu Xu
Hongliang Sun
Tongxi Liu
Kaining Shi
Wu Wang
Publication date
01-07-2018
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 7/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-018-5329-y

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