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European Radiology
Published in: European Radiology 8/2018

01-08-2018 | Gastrointestinal

Quantitative susceptibility mapping in combination with water-fat separation for simultaneous liver iron and fat fraction quantification

Authors: Huimin Lin, Hongjiang Wei, Naying He, Caixia Fu, Shu Cheng, Jun Shen, Baisong Wang, Xu Yan, Chunlei Liu, Fuhua Yan

Published in: European Radiology | Issue 8/2018

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Abstract

Purposes

To evaluate the feasibility of simultaneous quantification of liver iron concentration (LIC) and fat fraction (FF) using water-fat separation and quantitative susceptibility mapping (QSM).

Methods

Forty-five patients suspected of liver iron overload (LIO) were included. A volumetric interpolated breath-hold examination sequence for QSM and FF, a fat-saturated gradient echo sequence for R2*, a spin echo sequence for LIC measurements and MRS analyses for FF (FF-MRS) were performed. Magnetic susceptibility and FF were calculated using a water-fat separation method (FF-MRI). Correlation and receiver operating characteristic analyses were performed.

Results

Magnetic susceptibility showed strong correlation with LIC (rs=0.918). The optimal susceptibility cut-off values were 0.34, 0.63, 1.29 and 2.23 ppm corresponding to LIC thresholds of 1.8, 3.2, 7.0 and 15.0 mg/g dry weight. The area under the curve (AUC) were 0.948, 0.970, 1 and 1, respectively. No difference in AUC was found between susceptibility and R2* at all LIC thresholds. Correlation was found between FF-MRI and FF-MRS (R2=0.910).

Conclusions

QSM has a high diagnostic performance for LIC quantification, similar to that of R2*. FF-MRI provides simultaneous fat quantification. Findings suggest QSM in combination with water-fat separation has potential value for evaluating LIO, especially in cases with coexisting steatosis.

Key Points

• Magnetic susceptibility showed strong correlation with LIC (r s =0.918).
• QSM showed high diagnostic performance for LIC, similar to that of R 2 * .
• Simultaneously estimated FF-MRI showed strong correlation with MR-Spectroscopy-based FF (R 2 =0.910).
• QSM combining water-fat separation has quantitative value for LIO with coexisted steatosis.
Appendix
Available only for authorised users
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Metadata
Title
Quantitative susceptibility mapping in combination with water-fat separation for simultaneous liver iron and fat fraction quantification
Authors
Huimin Lin
Hongjiang Wei
Naying He
Caixia Fu
Shu Cheng
Jun Shen
Baisong Wang
Xu Yan
Chunlei Liu
Fuhua Yan
Publication date
01-08-2018
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 8/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-017-5263-4

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