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European Radiology

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01-04-2017 | Magnetic Resonance

Characterizing amide proton transfer imaging in haemorrhage brain lesions using 3T MRI

Authors: Ha-Kyu Jeong, Kyunghwa Han, Jinyuan Zhou, Yansong Zhao, Yoon Seong Choi, Seung-Koo Lee, Sung Soo Ahn

Published in: European Radiology | Issue 4/2017

Abstract

Objectives

The aim of this study was to characterize amide proton transfer (APT)-weighted signals in acute and subacute haemorrhage brain lesions of various underlying aetiologies.

Methods

Twenty-three patients with symptomatic haemorrhage brain lesions including tumorous (n = 16) and non-tumorous lesions (n = 7) were evaluated. APT imaging was performed and analyzed with magnetization transfer ratio asymmetry (MTR _asym). Regions of interest were defined as the enhancing portion (when present), acute or subacute haemorrhage, and normal-appearing white matter based on anatomical MRI. MTR _asym values were compared among groups and components using a linear mixed model.

Results

MTR _asym values were 3.68 % in acute haemorrhage, 1.6 % in subacute haemorrhage, 2.65 % in the enhancing portion, and 0.38 % in normal white matter. According to the linear mixed model, the distribution of MTR _asym values among components was not significantly different between tumour and non-tumour groups. MTR _asym in acute haemorrhage was significantly higher than those in the other regions regardless of underlying pathology.

Conclusions

Acute haemorrhages showed high MTR _asym regardless of the underlying pathology, whereas subacute haemorrhages showed lower MTR _asym than acute haemorrhages. These results can aid in the interpretation of APT imaging in haemorrhage brain lesions.

Key Points

• Acute haemorrhages show significantly higher MTR _asym values than subacute haemorrhages.

• MTR _asym is higher in acute haemorrhage than in enhancing tumour tissue.

• MTR _asym in haemorrhage does not differ between tumorous and non-tumorous lesions.

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Title: Characterizing amide proton transfer imaging in haemorrhage brain lesions using 3T MRI
Authors: Ha-Kyu Jeong
Kyunghwa Han
Jinyuan Zhou
Yansong Zhao
Yoon Seong Choi
Seung-Koo Lee
Sung Soo Ahn
Publication date: 01-04-2017
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 4/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4477-1

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Characterizing amide proton transfer imaging in haemorrhage brain lesions using 3T MRI

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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