Skip to main content
Top
Published in: European Radiology 2/2017

01-02-2017 | Cardiac

The number of unrecognized myocardial infarction scars detected at DE-MRI increases during a 5-year follow-up

Authors: Raquel Themudo, Lars Johansson, Charlotte Ebeling-Barbier, Lars Lind, Håkan Ahlström, Tomas Bjerner

Published in: European Radiology | Issue 2/2017

Login to get access

Abstract

Objectives

In an elderly population, the prevalence of unrecognized myocardial infarction (UMI) scars found via late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) imaging was more frequent than expected. This study investigated whether UMI scars detected with LGE-CMR at age 70 would be detectable at age 75 and whether the scar size changed over time.

Methods

From 248 participants that underwent LGE-CMR at age 70, 185 subjects underwent a follow-up scan at age 75. A myocardial infarction (MI) scar was defined as late enhancement involving the subendocardium.

Results

In the 185 subjects that underwent follow-up, 42 subjects had a UMI scar at age 70 and 61 subjects had a UMI scar at age 75. Thirty-seven (88 %) of the 42 UMI scars seen at age 70 were seen in the same myocardial segment at age 75. The size of UMI scars did not differ between age 70 and 75.

Conclusions

The prevalence of UMI scars detected at LGE-CMR increases with age. During a 5-year follow-up, 88 % (37/42) of the UMI scars were visible in the same myocardial segment, reassuring that UMI scars are a consistent finding. The size of UMI scars detected during LGE-CMR did not change over time.

Key Points

UMI scars detected by LGE-CMR are frequent in elderly.
The prevalence of UMI scars detected with LGE-CMR increases with age.
UMI scar size does not change over time.
Literature
1.
go back to reference Kannel WB, Abbott RD (1984) Incidence and prognosis of unrecognized myocardial infarction. An update on the Framingham study. N Engl J Med 311(18):1144–1147CrossRefPubMed Kannel WB, Abbott RD (1984) Incidence and prognosis of unrecognized myocardial infarction. An update on the Framingham study. N Engl J Med 311(18):1144–1147CrossRefPubMed
2.
go back to reference Barbier CE, Bjerner T, Johansson L, Lind L, Ahlstrom H (2006) Myocardial scars more frequent than expected: magnetic resonance imaging detects potential risk group. J Am Coll Cardiol 48(4):765–771CrossRefPubMed Barbier CE, Bjerner T, Johansson L, Lind L, Ahlstrom H (2006) Myocardial scars more frequent than expected: magnetic resonance imaging detects potential risk group. J Am Coll Cardiol 48(4):765–771CrossRefPubMed
3.
go back to reference Kwong RY, Chan AK, Brown KA et al (2006) Impact of unrecognized myocardial scar detected by cardiac magnetic resonance imaging on event-free survival in patients presenting with signs or symptoms of coronary artery disease. Circulation 113(23):2733–2743CrossRefPubMed Kwong RY, Chan AK, Brown KA et al (2006) Impact of unrecognized myocardial scar detected by cardiac magnetic resonance imaging on event-free survival in patients presenting with signs or symptoms of coronary artery disease. Circulation 113(23):2733–2743CrossRefPubMed
4.
go back to reference Kim HW, Klem I, Shah DJ et al (2009) Unrecognized non-Q-wave myocardial infarction: prevalence and prognostic significance in patients with suspected coronary disease. PLoS Med 6(4), e1000057CrossRefPubMedPubMedCentral Kim HW, Klem I, Shah DJ et al (2009) Unrecognized non-Q-wave myocardial infarction: prevalence and prognostic significance in patients with suspected coronary disease. PLoS Med 6(4), e1000057CrossRefPubMedPubMedCentral
6.
go back to reference Themudo RE, Lindahl B, Johansson L, et al. Unrecognized myocardial scars detected by delayed-enhanced MRI are associated with increased levels of NT-proBNP. Coron Artery Dis 22(3):158-164. Themudo RE, Lindahl B, Johansson L, et al. Unrecognized myocardial scars detected by delayed-enhanced MRI are associated with increased levels of NT-proBNP. Coron Artery Dis 22(3):158-164.
7.
go back to reference de Lemos JA, Morrow DA, Bentley JH et al (2001) The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes. N Engl J Med 345(14):1014–1021CrossRefPubMed de Lemos JA, Morrow DA, Bentley JH et al (2001) The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes. N Engl J Med 345(14):1014–1021CrossRefPubMed
8.
go back to reference Lind L, Fors N, Hall J, Marttala K, Stenborg A (2005) A comparison of three different methods to evaluate endothelium-dependent vasodilation in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Arterioscler Thromb Vasc Biol 25(11):2368–2375CrossRefPubMed Lind L, Fors N, Hall J, Marttala K, Stenborg A (2005) A comparison of three different methods to evaluate endothelium-dependent vasodilation in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Arterioscler Thromb Vasc Biol 25(11):2368–2375CrossRefPubMed
9.
go back to reference Ebeling Barbier C, Bjerner T, Hansen T et al (2007) Clinically unrecognized myocardial infarction detected at MR imaging may not be associated with atherosclerosis. Radiology 245(1):103–110CrossRefPubMed Ebeling Barbier C, Bjerner T, Hansen T et al (2007) Clinically unrecognized myocardial infarction detected at MR imaging may not be associated with atherosclerosis. Radiology 245(1):103–110CrossRefPubMed
10.
go back to reference Hunold P, Schlosser T, Vogt FM et al (2005) Myocardial late enhancement in contrast-enhanced cardiac MRI: distinction between infarction scar and non-infarction-related disease. AJR Am J Roentgenol 184(5):1420–1426CrossRefPubMed Hunold P, Schlosser T, Vogt FM et al (2005) Myocardial late enhancement in contrast-enhanced cardiac MRI: distinction between infarction scar and non-infarction-related disease. AJR Am J Roentgenol 184(5):1420–1426CrossRefPubMed
11.
go back to reference Sandstede J, Lipke C, Beer M et al (2000) Age- and gender-specific differences in left and right ventricular cardiac function and mass determined by cine magnetic resonance imaging. Eur Radiol 10(3):438–442CrossRefPubMed Sandstede J, Lipke C, Beer M et al (2000) Age- and gender-specific differences in left and right ventricular cardiac function and mass determined by cine magnetic resonance imaging. Eur Radiol 10(3):438–442CrossRefPubMed
12.
go back to reference Cerqueira MD, Weissman NJ, Dilsizian V et al (2002) Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 105(4):539–542CrossRefPubMed Cerqueira MD, Weissman NJ, Dilsizian V et al (2002) Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 105(4):539–542CrossRefPubMed
13.
go back to reference vanden Driesen RI, Slaughter RE, Strugnell WE (2006) MR findings in cardiac amyloidosis. AJR Am J Roentgenol 186(6):1682–1685CrossRef vanden Driesen RI, Slaughter RE, Strugnell WE (2006) MR findings in cardiac amyloidosis. AJR Am J Roentgenol 186(6):1682–1685CrossRef
14.
go back to reference Sheifer SE, Gersh BJ, Yanez ND 3rd, Ades PA, Burke GL, Manolio TA (2000) Prevalence, predisposing factors, and prognosis of clinically unrecognized myocardial infarction in the elderly. J Am Coll Cardiol 35(1):119–126CrossRefPubMed Sheifer SE, Gersh BJ, Yanez ND 3rd, Ades PA, Burke GL, Manolio TA (2000) Prevalence, predisposing factors, and prognosis of clinically unrecognized myocardial infarction in the elderly. J Am Coll Cardiol 35(1):119–126CrossRefPubMed
15.
go back to reference de Torbal A, Boersma E, Kors JA et al (2006) Incidence of recognized and unrecognized myocardial infarction in men and women aged 55 and older: the Rotterdam Study. Eur Heart J 27(6):729–736CrossRefPubMed de Torbal A, Boersma E, Kors JA et al (2006) Incidence of recognized and unrecognized myocardial infarction in men and women aged 55 and older: the Rotterdam Study. Eur Heart J 27(6):729–736CrossRefPubMed
16.
go back to reference Leening MJ, Elias-Smale SE, Felix JF, et al. Unrecognised myocardial infarction and long-term risk of heart failure in the elderly: the Rotterdam Study. Heart 96(18):1458-1462 Leening MJ, Elias-Smale SE, Felix JF, et al. Unrecognised myocardial infarction and long-term risk of heart failure in the elderly: the Rotterdam Study. Heart 96(18):1458-1462
17.
go back to reference Boland LL, Folsom AR, Sorlie PD et al (2002) Occurrence of unrecognized myocardial infarction in subjects aged 45 to 65 years (the ARIC study). Am J Cardiol 90(9):927–931CrossRefPubMed Boland LL, Folsom AR, Sorlie PD et al (2002) Occurrence of unrecognized myocardial infarction in subjects aged 45 to 65 years (the ARIC study). Am J Cardiol 90(9):927–931CrossRefPubMed
18.
go back to reference Schelbert EB, Cao JJ, Sigurdsson S et al (2012) Prevalence and prognosis of unrecognized myocardial infarction determined by cardiac magnetic resonance in older adults. JAMA 308(9):890–896CrossRefPubMedPubMedCentral Schelbert EB, Cao JJ, Sigurdsson S et al (2012) Prevalence and prognosis of unrecognized myocardial infarction determined by cardiac magnetic resonance in older adults. JAMA 308(9):890–896CrossRefPubMedPubMedCentral
19.
go back to reference Kim RJ, Fieno DS, Parrish TB et al (1999) Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation 100(19):1992–2002CrossRefPubMed Kim RJ, Fieno DS, Parrish TB et al (1999) Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation 100(19):1992–2002CrossRefPubMed
Metadata
Title
The number of unrecognized myocardial infarction scars detected at DE-MRI increases during a 5-year follow-up
Authors
Raquel Themudo
Lars Johansson
Charlotte Ebeling-Barbier
Lars Lind
Håkan Ahlström
Tomas Bjerner
Publication date
01-02-2017
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 2/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-016-4439-7

Other articles of this Issue 2/2017

European Radiology 2/2017 Go to the issue