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01-02-2017 | Neuro

Intravenous injection of gadobutrol in an epidemiological study group did not lead to a difference in relative signal intensities of certain brain structures after 5 years

Authors: Marie-Luise Kromrey, Kim Rouven Liedtke, Till Ittermann, Sönke Langner, Michael Kirsch, Werner Weitschies, Jens-Peter Kühn

Published in: European Radiology | Issue 2/2017

Abstract

Purpose

To investigate if application of macrocyclic gadolinium-based contrast agents in volunteers is associated with neuronal deposition detected by magnetic resonance imaging in a 5-year longitudinal survey.

Materials and methods

Three hundred eighty-seven volunteers who participated in a population-based study were enrolled. Subjects underwent plain T1-weighted brain MRI at baseline and 5 years later with identical sequence parameters. At baseline, 271 participants additionally received intravenous injection of the macrocyclic contrast agent gadobutrol (1.5 mmol/kg). A control group including 116 subjects received no contrast agent. Relative signal intensities of thalamus, pallidum, pons and dentate nucleus were compared at baseline and follow-up.

Results

No difference in relative signal intensities was observed between contrast group (thalamus, p = 0.865; pallidum, p = 0.263; pons, p = 0.533; dentate nucleus, p = 0.396) and control group (thalamus, p = 0.683; pallidum; p = 0.970; pons, p = 0.773; dentate nucleus, p = 0.232) at both times. Comparison between both groups revealed no significant differences in relative signal intensities (thalamus, p = 0.413; pallidum, p = 0.653; pons, p = 0.460; dentate nucleus, p = 0.751). The study showed no significant change in globus pallidus-to-thalamus or dentate nucleus-to-pons ratios.

Conclusions

Five years after administration of a 1.5-fold dose gadobutrol to normal subjects, signal intensity of thalamus, pallidum, pons and dentate nucleus did not differ from participants who had not received gadobutrol.

Key Points

• Gadobutrol does not lead to neuronal signal alterations after 5 years.

• Neuronal deposition of macrocyclic contrast agent could not be confirmed.

• Macrocyclic contrast agents in a proven dosage are safe.

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Title: Intravenous injection of gadobutrol in an epidemiological study group did not lead to a difference in relative signal intensities of certain brain structures after 5 years
Authors: Marie-Luise Kromrey
Kim Rouven Liedtke
Till Ittermann
Sönke Langner
Michael Kirsch
Werner Weitschies
Jens-Peter Kühn
Publication date: 01-02-2017
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 2/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4418-z

At a glance: The STEP trials

Springer Medicine

Intravenous injection of gadobutrol in an epidemiological study group did not lead to a difference in relative signal intensities of certain brain structures after 5 years

Abstract

Purpose

Materials and methods

Results

Conclusions

Key Points

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusions

Key Points

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