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01-02-2017 | Musculoskeletal

Prediction of medial tibiofemoral compartment joint space loss progression using volumetric cartilage measurements: Data from the FNIH OA biomarkers consortium

Authors: Nima Hafezi-Nejad, Ali Guermazi, Frank W. Roemer, David J. Hunter, Erik B. Dam, Bashir Zikria, C. Kent Kwoh, Shadpour Demehri

Published in: European Radiology | Issue 2/2017

Abstract

Objectives

Investigating the association between baseline cartilage volume measurements (and initial 24th month volume loss) with medial compartment Joint-Space-Loss (JSL) progression (>0.7 mm) during 24–48th months of study.

Methods

Case and control cohorts (Biomarkers Consortium subset from the Osteoarthritis Initiative (OAI)) were defined as participants with (n=297) and without (n=303) medial JSL progression (during 24–48th months). Cartilage volume measurements (baseline and 24th month loss) were obtained at five knee plates (medial-tibial, lateral-tibial, medial-femoral, lateral-femoral and patellar), and standardized values were analysed. Multivariate logistic regression was used with adjustment for known confounders. Artificial-Neural-Network analysis was conducted by Multi-Layer-Perceptrons (MLPs) including baseline determinants, and baseline (1) and interval changes (2) in cartilage volumes.

Results

Larger baseline lateral-femoral cartilage volume was predictive of medial JSL (OR: 1.29 (1.01–1.64)). Greater initial 24th month lateral-femoral cartilage volume-loss (OR: 0.48 (0.27–0.84)) had protective effect on medial JSL during 24–48th months of study. Baseline and interval changes in lateral-femoral cartilage volume, were the most important estimators for medial JSL progression (importance values: 0.191(0.177–0.204), 0.218(0.207–0.228)) in the ANN analyses.

Conclusions

Cartilage volumes (both at baseline and their change during the initial 24 months) in the lateral femoral plate were predictive of medial JSL progression.

Key Points

• Baseline lateral femoral cartilage volume is directly associated with medial JSL progression.

• 24-month lateral femoral cartilage loss is inversely associated with medial JSL progression.

• Lateral femoral cartilage volume is most important in association with medial JSL progression.

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Title: Prediction of medial tibiofemoral compartment joint space loss progression using volumetric cartilage measurements: Data from the FNIH OA biomarkers consortium
Authors: Nima Hafezi-Nejad
Ali Guermazi
Frank W. Roemer
David J. Hunter
Erik B. Dam
Bashir Zikria
C. Kent Kwoh
Shadpour Demehri
Publication date: 01-02-2017
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 2/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4393-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Prediction of medial tibiofemoral compartment joint space loss progression using volumetric cartilage measurements: Data from the FNIH OA biomarkers consortium

Abstract

Objectives

Methods

Results

Conclusions

Key Points

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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