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Open Access 01-02-2017 | Interventional

Predictors of treatment response following aspiration sclerotherapy of hepatic cysts: an international pooled analysis of individual patient data

Authors: Titus F. M. Wijnands, Maxime Ronot, Tom J. G. Gevers, Julie Benzimra, Leo J. Schultze Kool, Valérie Vilgrain, Joost P. H. Drenth

Published in: European Radiology | Issue 2/2017

Abstract

Objectives

To identify predictive variables of treatment response following aspiration sclerotherapy of large symptomatic hepatic cysts.

Methods

We collected individual patient data from two tertiary referral centres and included all patients treated with aspiration sclerotherapy of a large (>5 cm), symptomatic hepatic cyst. At six months, clinical response was defined as complete or incomplete. Secondary, suboptimal technical response was defined as lower quartile of cyst reduction. Predictive variables of clinical and technical response were analyzed by logistic regression analysis.

Results

We included 86 patients (58 ± 10 years; female 90 %). Complete clinical response rate was 55 %. Median cyst diameter and volume reduction were 71 % (IQR 50-87 %) and 98 % (IRQ 88-100 %), respectively. Patients with complete clinical response had a significantly higher cyst reduction compared to incomplete responders (OR 1.02, 95 % CI 1.00-1.04). Aspiration of haemorrhagic cyst fluid (OR 4.39, 95 % CI 1.34-14.39) or a lower cyst reduction at one month (OR 1.06, 95 % CI 1.02-1.10) was associated with a suboptimal technical response at six months.

Conclusion

Complete clinical response is associated with effective cyst reduction. Aspiration of haemorrhagic cyst fluid or a restricted diameter reduction at one month predicts a suboptimal technical treatment response, however, these variables did not predict symptom disappearance.

Key Points

• Aspiration sclerotherapy of hepatic cysts shows excellent clinical and technical efficacy.

• Optimal clinical responders have a markedly higher cyst reduction.

• Haemorrhagic aspirate and a strong fluid reaccumulation predict suboptimal cyst reduction.

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Title: Predictors of treatment response following aspiration sclerotherapy of hepatic cysts: an international pooled analysis of individual patient data
Authors: Titus F. M. Wijnands
Maxime Ronot
Tom J. G. Gevers
Julie Benzimra
Leo J. Schultze Kool
Valérie Vilgrain
Joost P. H. Drenth
Publication date: 01-02-2017
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 2/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4363-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Predictors of treatment response following aspiration sclerotherapy of hepatic cysts: an international pooled analysis of individual patient data

Abstract

Objectives

Methods

Results

Conclusion

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

Key Points

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